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At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Senior Scientist, Target Discovery and Biology

POSITION DESCRIPTION

Position: Senior Scientist, Target Discovery and Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining proprietary, high throughput, CRISPR‐enabled genome-scale synthetic lethal (SL) screenings for discovery of targets and patient selection biomarkers with high‐resolution protein crystallography, computational biology and clinical informatics. Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

We now have an outstanding opportunity available at our Montreal site for a motivated and accomplished Ph.D.-level senior scientist who would like to get in early and grow with the company. The successful candidate will have a thorough background in at least one of the following research areas: DNA repair, cancer biology, synthetic lethality, and/or genome engineering. The candidate will become a vital member of our SL platform team where he/she will contribute both experimentally and intellectually to design and execute new SL campaigns and to generate a pool of completely validated drug targets to advance our portfolio. A critical component of the job will be the close collaboration with internal drug discovery teams and external investigators.

 

RESPONSIBILITIES

  • Establish expertise and maintain a thorough understanding of DNA damage and repair, cancer biology, synthetic lethality, and genome engineering.
  • Utilize CRISPR/CAS9 and other genetic tools to validate novel targets, and participate in drug discovery programs.
  • Apply this skill set to identify and fully validate new targets for cancer biology.
  • Plan and execute experiments to uncover mechanisms of action for SL interactions.
  • Develop cell-based assays and contribute intellectually to drug development programs.
  • Facilitate the development of computational biology tools by working closely with the bioinformatics team.
  • Support in vivo pharmacology and translational science personnel in clinical strategy development (i.e. biomarkers, patient selection criteria, etc.).

 

QUALIFICATIONS

  • Ph.D. and/or Post-doctoral fellowship in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, or related fields with experience in DNA damage and repair pathways, chromatin remodelling, telomeres and/or cell cycle control.
  • Deep understanding and experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockouts, point mutants, and knock-in cell lines
  • Experience in functional genomics (especially RNAi or CRISPR screens) is highly desired
  • Expertise in cell and molecular biology techniques needed (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment
  • Experience in pre-clinical drug discovery is an asset

Scientist, Computational Biology and Bioinformatics

POSITION DESCRIPTION

Position: Scientist, Computational Biology and Bioinformatics

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com/news).  Repare develops next generation, precision oncology drugs that target specific vulnerabilities of tumor cells.  This is accomplished by combining proprietary, high throughput, CRISPR‐enabled genome-scale synthetic lethal screenings for the discovery of targets and patient selection biomarkers with high‐resolution protein crystallography, computational biology, and clinical informatics.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a motivated and accomplished computational biologist/bioinformatician.  The successful candidate will develop and apply advanced data analysis approaches to impact critical decisions across all stages of oncology drug R&D, from target identification, translational research to clinical development.  A critical component of the job will be the close collaboration with internal drug discovery teams and external investigators.

Job title/position will depend on the experience of the candidate.

 

Responsibilities:

–  Develop novel methods/algorithms for analysis and integration of high-throughput functional genomics studies.

–  Apply and develop data-mining tools and techniques for integrative analysis and visualization of multi-dimensional large-scale data sets, including next-generation sequencing, CRISPR screening, and cancer Omics data.

–  Execute in-depth analyses of cancer Omics and experimental data to inform target identification and patient selection in collaboration with bench scientists.

–  Acts as an expert consultant and scientific resource on computational and statistical topics.

 

Qualifications:

–  PhD in Computational Biology, System Biology, Bioinformatics, or related fields with 3+ years of post-graduate experience.

–  Proficiency with R, Python or other scripting languages for statistical computing and graphics.

–  A solid understanding of molecular biology; experience in cancer research and DNA Damage and Repair is highly desirable.

–  Demonstrated experience with statistical analysis of large-scale biological data.

–  Familiarity with parallel computing, database (e.g., SQL) and cloud computing.

Research Scientist, Biology

 

POSITION DESCRIPTION

Position Research Scientist, Biology

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

COMPANY BACKGROUND

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare is backed by tier-one strategic and institutional biotechnology investors with track records for high-impact drug development, including Versant Ventures and MPM Capital.

 

RESEARCH SCIENTIST

 

Repare Therapeutics is seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal (SL) cancer therapies. The individual should have extensive knowledge in both molecular and cellular biology techniques. Experience in genome editing technologies (i.e. CRISPR) and assay development/optimization is required. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

KEY RESPONSIBILITIES

  • Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate cell line models for SL screens, target validation, and mechanism of action studies
  • Validate these cell lines using a variety of techniques: QPCR, western blot, functional (activity, microscopy) assays etc.
  • Work on the CRISPR screening platform: perform synthetic lethal screens and validate hits using cell proliferation assays
  • Execute experiments in a timely, efficient, and independent manner.
  • Present clearly and succinctly in a variety of internal settings
  • Good organizational and time-management skills including the ability to manage several projects simultaneously

 

 

EDUCATION

 

  • Master’s degree (M.Sc.) or Ph.D./postdoc in biology or biochemistry
  • A minimum of 3 years of relevant employment experience in the field of drug discovery &/or genome engineering.
  • Effective communicate skills, both verbally and written.
  • Ability to work in a fast-paced environment.
  • Experience with computer software relevant to laboratory research and data interpretation.
  • Previous biotech or pharma industry experience is an asset.

Senior Scientist, Computational Chemistry

POSITION DESCRIPTION

 

Position: Senior Scientist, Computational Chemistry

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining proprietary, high throughput, CRISPR-enabled genome-scale synthetic lethal (SL) screenings for discovery of targets and patient selection biomarkers with high-resolution protein crystallography, computational biology and clinical informatics. Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We now have an outstanding opportunity available for a motivated and accomplished Ph.D.-level senior scientist who would like to get in early and grow with the company. The successful candidate will have a thorough background in applied computational chemistry. The candidate will become a vital member of our chemistry team where he/she will contribute intellectually to multiple projects by applying cutting edge in silico methods to identify new drug candidates. The successful candidate will have the ability to implement the most effective methods/software and the desire to work in close collaboration within a multi-disciplinary team.

 

RESPONSIBILITIES

  • Lead the computational chemistry efforts at Repare
  • Use internally-generated protein crystal structures to design novel inhibitors
  • Apply structure-based and ligand-based drug design methods to accelerate the drug discovery cycle
  • In collaboration with the medicinal chemists, propose structure-based hypotheses to resolve current issues in projects
  • Communicate the limitations of the theoretical models to help in prioritizing efforts
  • Provide protein structure input to address key biological questions
  • Apply virtual screening methods to identify novel chemical leads
  • Perform druggability assessments to enable prioritization of new protein targets
  • Obtain and setup suitable hardware/software to carry out duties
  • Help interpret HTS and SAR data

 

QUALIFICATIONS

  • Ph.D. and/or Post-doctoral fellowship in theoretical chemistry, computational chemistry, computational physics applied to chemistry, or related fields
  • Deep understanding of at least two of these fields: molecular dynamics, applied quantum chemistry, statistical mechanics applied to chemistry, virtual screening methods
  • Mastery of at least one major molecular design commercial software package (MOE, OpenEye or Schrodinger’s suites) and ability to integrate different software platforms
  • Experience in both structure-based and ligand-based drug design
  • Interest and familiarity with biology concepts
  • Ability to communicate in an open, clear, timely and consistent manner
  • Sufficient understanding of organic chemistry to enable effective communication with medicinal chemists
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