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At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Computational biologist

 

POSITION DESCRIPTION

Position: Computational biologist

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com/news).  Repare develops next generation, precision oncology drugs that target specific vulnerabilities of tumor cells in clearly defined patient populations.  Founded by leading experts at the forefront of DNA damage and repair (DDR) cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a motivated and accomplished computational scientist.  The successful candidate will work closely with biologists, chemists, and translational scientists to impact critical decisions across all stages of drug R&D, from target identification, patient stratification to clinical development.  If you are aspired to become an expert of drug discovery and development, experienced in generating novel insights by combining biology and analysis of genome-scale large data, and savvy with computational techniques in statistics and mathematics,  you will thrive in our team-oriented, fast-paced, dynamic environment!

Job title will depend on the experience of the candidate.

Responsibilities:

–  Collaborate with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based oncology drug discovery

–  Apply and develop computational, statistical, and machine learning methods to mine multi-dimensional genome-scale data sets and derive biological insights

–  Execute integrative analysis of cancer omics, clinical information and functional genomic data to support prioritization of targets and stratification of patients

–  Perform systematic analysis to characterize the landscape and natural history of DDR pathways in human cancer

–  In collaboration with discovery and translational science teams, propose testable hypotheses and experimental verification plans to support program decisions

–  Acts as an expert consultant and scientific resource on computational and statistical topics

 

Qualifications:

–  PhD in Computational Biology, System Biology, Bioinformatics, or related fields

–  3+ years of post-graduate working experience in oncology drug discovery and/or translational setting

–  Solid understanding of cellular and molecular biology and cancer biology.  Experience on DNA Damage and Repair is highly desirable

–  Strong hands-on programing skills (R, Python, Unix, SQL, etc)

–  Solid understanding of probability and statistics

–  Experience with network-based systems biology platforms and methodologies is highly desirable

Senior Research Scientist – Pharmacology

POSITION DESCRIPTION

 

Position: Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combinations of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships, therapeutic window and performing mechanism-of-action studies.

 

RESPONSIBILITIES

  • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
  • To identify and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
  • To research, identify and develop relevant pharmacodynamic markers to monitor compound target engagement in vivo.
  • To develop pharmacodynamic assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR, FACS or other means.
  • To harvest tumor and tissue samples from treated animals and establish PK/PD and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
  • To conduct drug PK/PD modeling to optimize dose/scheduling and therapeutic window.
  • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

  • MSc or PhD in biological sciences and minimum of 3 years relevant experience.
  • Experience in oncology, DNA repair and/or chromatin remodelling is essential.
  • A strong background in cell biology and quantitative cell-based assay development using various modalities including FACS is essential.
  • Diverse experience in cell and molecular biology techniques to monitor PK/PD relationships is essential.
  • Experience in pre-clinical drug discovery in an industrial setting is an asset.
  • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models is an asset.
  • Experience with pharmacodynamic modelling software is an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, documentation etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

Clinical Operations Lead

POSITION DESCRIPTION

 

Position: Clinical Operations Lead

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com/news).  Repare develops next generation, precision oncology drugs that target specific vulnerabilities of tumor cells in clearly defined patient populations.  Founded by leading experts at the forefront of DNA damage and repair (DDR) cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a motivated and accomplished computational scientist.  The successful candidate will work closely with biologists, chemists, and translational scientists to impact critical decisions across all stages of drug R&D, from target identification, patient stratification to clinical development.  If you are aspired to become an expert of drug discovery and development, experienced in generating novel insights by combining biology and analysis of genome-scale large data, and savvy with computational techniques in statistics and mathematics,  you will thrive in our team-oriented, fast-paced, dynamic environment!

Job title will depend on the experience of the candidate.

 

Summary of Position:
Repare Therapeutics is looking for an experienced and passionate individual to lead clinical operations for our oncology programs. This Clinical development and Operation Lead position reports directly to the CMO and work collaboratively with the broader oncology development team to advance the science into the clinic and to bring medicines to patients who desperately need them. For the right individual this role will not only lead and develop a team of clinical operations professionals but provide an opportunity to work with accomplished drug developers who are passionate about the work and driven to help patients in need.

Position Responsibilities include:

  • Develop and implement clinical project plans in accordance with corporate and regulatory objectives
  • Oversight of clinical operation activities (vendor selection, trial management, site monitoring, vendor management, TMF, data management, IMP management, project management, etc.) for one or more clinical programs.
  • Contribute to key study documents in conjunction with other functional area leads (e.g. protocols, project plans and timelines, statistical analysis plans, final study reports, etc.)
  • Manage clinical trial resources and reforecasting projections, including hiring plans and budgets
  • Coordinate advisory boards, investigator meetings and CRA trainings
  • Ensure clinical trial compliance with all SOPs and GCP/ICH guidelines; maintain an inspection readiness state throughout the lifecycle of the trial
  • Proactively identify, resolve and escalate issues that may jeopardize clinical study completion on time or within budget
  • Assist in the identification and activation of clinical sites
  • Contribute to global clinical / regulatory submissions
  • Communicate study updates to senior leadership and in open forum presentations
  • Undertake line management responsibilities for assigned team members, serving as coach and mentor
  • Develop and maintain oversight of departmental SOPs to ensure compliance
  • May require travel, including international travel

Candidate Requirements:

  • Bachelor’s in a scientific discipline; advanced degree preferred
  • Minimum 10 years of experience in a biotech/pharmaceutical/ CRO setting, principally in oncology drug development; minimum 7 years of clinical operations experience; minimum 5 years in a supervisory role
  • Proven track record of effectively managing contract research organizations
  • Demonstration of effective leadership through vision for her/his team, coaching and mentoring, and organizational development
  • Highly organized, outcome oriented, self-motivated performance
  • Comfortable in a fast-paced small biotech environment with the ability to adapt to change
  • In depth knowledge and understanding of all aspects of clinical operations management, with a track record of successfully managing programs to completion on time and on budget
  • Excellent interpersonal skills, ability to develop important relationships with key stakeholders across a variety of disciplines, strong conflict management and negotiation skills
  • Ability to analyze complex issues to develop relevant and realistic plans, programs and recommendations
  • Excellent working knowledge of federal regulatory requirements and guidelines for Good Clinical Practice
  • Outstanding oral and written communication skills including experience authoring clinical protocols and other key trial documents

Repare Therapeutics is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Research Scientist – DMPK

POSITION DESCRIPTION

 

Position: Research Scientist – DMPK

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com/news).  Repare develops next generation, precision oncology drugs that target specific vulnerabilities of tumor cells in clearly defined patient populations.  Founded by leading experts at the forefront of DNA damage and repair (DDR) cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a motivated and accomplished computational scientist.  The successful candidate will work closely with biologists, chemists, and translational scientists to impact critical decisions across all stages of drug R&D, from target identification, patient stratification to clinical development.  If you are aspired to become an expert of drug discovery and development, experienced in generating novel insights by combining biology and analysis of genome-scale large data, and savvy with computational techniques in statistics and mathematics,  you will thrive in our team-oriented, fast-paced, dynamic environment!

Job title will depend on the experience of the candidate.

 

We now have an outstanding opportunity available at our Montreal site for a motivated and accomplished ADME/DMPK scientist who would like to get in early and grow with the company. The successful candidate will have a thorough, hands-on background in drug metabolism and pharmacokinetics.  A demonstrated expertise performing in vitro techniques with LCMS analysis is needed.  A critical component of the job will be the close collaboration with internal drug discovery teams and CROs.

 

RESPONSIBILITIES

  • Develop, validate and execute novel ADME/DMPK assays.
  • Utilize in vitro and analytical tools to elucidate metabolic and elimination mechanisms for new chemical entities.
  • Review large amounts of data to select appropriate compounds for assay screening.
  • Plan and execute experiments to support progression of projects.
  • Contribute intellectually to drug development programs.

 

QUALIFICATIONS

  • in Chemistry, Biochemistry or related fields with several years of experience in ADME/DMPK in an industrial setting.  Recent PhD graduates in a related field with a keen interest to learn new techniques are encouraged to apply.

Experience in one or more of the following fields: assay development, pharmacokinetics, in vitro DMPK assays, metabolite identification and/or bioanalytical mass spectrometry.

Ability to communicate in an open, clear, timely and consistent manner.

  • Outstanding organizational skills (study planning, experimental design, lab notebooks etc..).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.
  • Experience in pre-clinical drug discovery is an asset.
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