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At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Senior Research Scientist - Enzymology

 

POSITION DESCRIPTION

Position Senior Research Scientist – Enzymology (permanent)

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

COMPANY BACKGROUND

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare is backed by tier-one strategic and institutional biotechnology investors with track records for high-impact drug development, including Versant Ventures and MPM Capital.

 

SENIOR RESEARCH SCIENTIST

 

Repare Therapeutics is seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal (SL) cancer therapies. The individual should have extensive knowledge in enzymology, assay development/optimization and biochemistry-related techniques. The scientist should provide expertise in designing biochemical assays and be able to conduct experiments aimed at biophysical characterization of lead compounds in support of lead ID/Opt activities. The candidate will lead part of a drug discovery program and oversee assay execution capabilities (internally & outsourced). Expertise in cell culture is an asset. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

 

 

 

KEY RESPONSIBILITIES

  • Perform enzyme kinetic analyses and MOA studies to characterize diverse biological enzyme systems, including kinases, polymerases & various DNA repair enzymes.
  • Design and develop medium-to-high throughput biochemical (ie. enzymatic, binding) microplate assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including FP, FRET, TR-FRET, BRET, HRTF, mass spectrometric, chromogenic, luminescence and radiometric.
  • Apply a range of biochemical and biophysical techniques to characterize the molecular interaction of novel small molecules with their protein target(s), including radiolabeled binding assays, fluorescence polarization assay, differential scanning fluorimetry (or thermal shift assay), surface plasmon resonance (SPR/Biacore) and isothermal titration calorimetry (ITC)
  • Develop assays using purified-component and cell-based systems configured to identify authentic small-molecule modulators and predict their activity in vivo.
  • Work closely with project teams and external CROs to deploy biochemical assays for high-throughput screening and to drive SAR development.
  • Oversee outsourcing of recombinant protein production & assay development to external CROs and monitor results
  • Execute experiments in a timely, efficient, and independent manner
  • Present clearly and succinctly in a variety of internal settings
  • Good organizational and time-management skills including the ability to manage several projects simultaneously
  • Excellent team work approach – work as part a cross-functional team including biologists, medicinal chemists and structural biologists

 

 

EDUCATION & SKILLS

 

  • PhD + 5yr experience or M.Sc. +8yr experience in Biochemistry or related discipline. Biopharmaceutical industry experience is highly preferred
  • Advanced knowledge and demonstrable track record in enzymology and enzyme inhibitor mechanism-of-action studies
  • Significant experience in developing robust enzyme-based assays to support high-throughput screening or medicinal chemistry efforts with a successful record of compound progression
  • Skilled in data analysis and reporting (IC50, EC50, assay variability assessment etc.)
  • Strong understanding of protein expression & purification systems
  • Experience with computer software relevant to laboratory research and data interpretation
  • Effective communicate skills, both verbally and written
  • Ability to work in a fast-paced and team-oriented environment

 

Computational biologist

 

POSITION DESCRIPTION

Position: Computational biologist

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com/news).  Repare develops next generation, precision oncology drugs that target specific vulnerabilities of tumor cells in clearly defined patient populations.  Founded by leading experts at the forefront of DNA damage and repair (DDR) cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a motivated and accomplished computational scientist.  The successful candidate will work closely with biologists, chemists, and translational scientists to impact critical decisions across all stages of drug R&D, from target identification, patient stratification to clinical development.  If you are aspired to become an expert of drug discovery and development, experienced in generating novel insights by combining biology and analysis of genome-scale large data, and savvy with computational techniques in statistics and mathematics,  you will thrive in our team-oriented, fast-paced, dynamic environment!

Job title will depend on the experience of the candidate.

Responsibilities:

–  Collaborate with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based oncology drug discovery

–  Apply and develop computational, statistical, and machine learning methods to mine multi-dimensional genome-scale data sets and derive biological insights

–  Execute integrative analysis of cancer omics, clinical information and functional genomic data to support prioritization of targets and stratification of patients

–  Perform systematic analysis to characterize the landscape and natural history of DDR pathways in human cancer

–  In collaboration with discovery and translational science teams, propose testable hypotheses and experimental verification plans to support program decisions

–  Acts as an expert consultant and scientific resource on computational and statistical topics

 

Qualifications:

–  PhD in Computational Biology, System Biology, Bioinformatics, or related fields

–  3+ years of post-graduate working experience in oncology drug discovery and/or translational setting

–  Solid understanding of cellular and molecular biology and cancer biology.  Experience on DNA Damage and Repair is highly desirable

–  Strong hands-on programing skills (R, Python, Unix, SQL, etc)

–  Solid understanding of probability and statistics

–  Experience with network-based systems biology platforms and methodologies is highly desirable

Oncology translational scientist

 

POSITION DESCRIPTION

Position: Oncology translational scientist

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com).  Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells in clearly stratified patient populations.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a highly motivated, independent and experienced oncology translational scientist who would like to get in early and grow with the company. As a founding member of the Translational Science team, the successful candidate will significantly impact the design and execution of translational strategies on assets in early stages of drug discovery and development, including indication selection, developing and implementing biomarker strategies, and delivering fit-for-purpose, clinical biomarker assays for clinical trials.

Job title will depend on the experience of the candidate.

Responsibilities

 

  • Develop indication selection and translational science strategies for lead assets in close collaboration with discovery and clinical teams
  • Partners with discovery team to lead, plan, and execute activities at CROs or academic collaborators to deliver key experimental studies that identify biomarkers for mechanism of action/resistance, target engagement, patient stratification, as well as early signs of efficacy (e.g., ctDNA)
  • Lead development and validation of fit-for-purpose pharmacodynamic and patient selection assays for incorporation into clinical trials
  • Work with clinical operations team to deploy biomarker assays to clinical sites/CROs prior to clinical trials and manage execution of assays and logistics of clinical sample handling during clinical trials
  • Interpret biomarker-related results emerging from tumors, assay development and clinical trials, communicating key findings internally and externally
  • Author biomarker sections and contribute to the generation of regulatory documents (e.g., IB, IND, clinical protocols, study reports)
  • Monitor emerging technologies and pilot new technologies for potential clinical utility in collaboration with discovery biology and clinical teams
  • Establish biobank of human tissues to support indication selection, assessment of biomarker variability, and assay validation

 

Qualifications

 

  • PhD in molecular oncology, molecular/cell biology, biochemistry, or genomics with relevant post-doctoral training
  • 3+ years industry experience in an oncology translational science role (biomarker identification and assay development, etc.)
  • Deep knowledge in tumor biology and DNA repair pathways

Expert understanding of biomarker assay platforms (e.g. IHC, NGS, qPCR) and their applications in clinical trials

Senior Research Scientist – Pharmacology

POSITION DESCRIPTION

Position: Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combinations of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships, therapeutic window and performing mechanism-of-action studies.

 

RESPONSIBILITIES

  • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
  • To identify and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
  • To research, identify and develop relevant pharmacodynamic markers to monitor compound target engagement in vivo.
  • To develop pharmacodynamic assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR or other means.
  • To harvest tumor and tissue samples from treated animals and establish PK/PD and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
  • To conduct drug PK/PD modeling to optimize dose/scheduling and therapeutic window.
  • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

 

  • MSc or PhD in biological sciences and minimum of 3 years relevant experience.
  • Experience in oncology, DNA repair and/or chromatin remodelling is essential.
  • A strong background in cell biology and quantitative cell-based assay development using various modalities is essential.
  • Diverse experience in cell and molecular biology techniques to monitor PK/PD relationships is essential.
  • Experience in pre-clinical drug discovery in an industrial setting is an asset.
  • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models is an asset.
  • Experience with pharmacodynamic modelling software is an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, documentation etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

Research Scientist – Pharmacology

POSITION DESCRIPTION

Position: Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combinations of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed efficacy, PK/PD relationships and therapeutic window.

 

RESPONSIBILITIES

  • To identify, develop and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
  • To maintain and expand cancer cell lines in culture in preparation for tumor inoculation.
  • To prepare drug formulations and dosing solutions.
  • To carry out all aspects of animal experimentation including tumor inoculations, drug administrations (multiple routes), animal health monitoring, anesthesia, surgeries, blood samplings (multiple routes), necropsies, and to monitor tumor progression through a variety of modalities including luminescence imaging.
  • To perform necropsies, terminal bleeds and tumor and tissue sample harvest from treated animals for the purposes of identifying drug-target engagement and monitoring tumor and tissue PK.
  • To maintain detailed laboratory notes, sample records and protocols. To compile, summarize and graph data for presentations.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

  • DEC in Animal Health Technology, BSc., or MSc in biological sciences with at least 2yrs of relevant experience. A background in oncology is a definite asset.
  • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models is essential including tumor implantation and measurement is essential.
  • Experience in drug administration by multiple routes (e.g. i.v., s.c, p.o., i.p.), tissue perfusion and blood sampling by multiple routes is essential.
  • Experience in pre-clinical drug discovery in an industrial, GLP setting (CRO or other) is an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, etc.).
  • Bilingual French/English (spoken and written) is an asset.
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.
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