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At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Research Scientist, Biology

 

POSITION DESCRIPTION

Position Research Scientist – Biology

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

COMPANY BACKGROUND

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare is backed by tier-one strategic and institutional biotechnology investors with track records for high-impact drug development, including Versant Ventures and MPM Capital.

 

RESEARCH SCIENTIST

 

Repare Therapeutics is seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal (SL) cancer therapies. The individual should have extensive knowledge in both molecular and cellular biology techniques. Expertise in cell culture is required. Experience in genome editing technologies (i.e. CRISPR) and assay development/optimization are an asset. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

KEY RESPONSIBILITIES

  • Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate cell line models for synthetic lethality screens, target validation, and mechanism of action studies
  • Validate these cell lines using a variety of techniques: qPCR, western blot, functional (activity, microscopy) assays, siRNA/shRNA etc.
  • Work on the CRISPR screening platform: utilize lentiviral particles to perform synthetic lethal screens and validate hits using cell proliferation assays
  • Execute experiments in a timely, efficient, and independent manner.
  • Present clearly and succinctly in a variety of internal settings
  • Good organizational and time-management skills including the ability to manage several projects simultaneously

 

 

EDUCATION

  • Master’s degree (M.Sc.)
  • A minimum of 5 years of relevant employment experience in cell culture, lentiviral infection and molecular biology.
  • Previous experience in the field of drug discovery &/or genome engineering is an asset.
  • Effective communicate skills, both verbally and written.
  • Ability to work in a fast-paced environment.
  • Experience with computer software relevant to laboratory research and data interpretation.
  • Previous biotech or pharma industry experience is an asset.

Senior Medicinal Chemist

POSITION DESCRIPTION

Position Senior Medicinal Chemist

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

COMPANY BACKGROUND

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare is backed by tier-one strategic and institutional biotechnology investors with track records for high-impact drug development, including Versant Ventures and MPM Capital.

 

SENIOR MEDICINAL CHEMIST

 

Repare Therapeutics is seeking an experienced medicinal chemist to support an internal drug discovery program.  The position requires strong scientific leadership and communication skills to collaborate with internal scientists and external service providers.   The selected applicant must combine excellent laboratory skills, knowledge of contemporary synthetic methods and ability to work effectively in a multidisciplinary environment.  Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

KEY RESPONSIBILITIES

  • Design small molecules inhibitors of target proteins with desired drug-like properties that meet a specified target profile.
  • Execute multi-step, complex organic syntheses in a timely, efficient, and independent manner.
  • Participate in the development of scientific goals for specific programs.
  • Interpret SAR with a clear understanding of relevant biological and ADME data.
  • Interact with molecular modelling, biology and DMPK colleagues to help form program strategy.

 

EDUCATION/EXPERIENCE

 

  • Ph.D. degree in Organic Chemistry with relevant post-doctoral experience
  • A minimum of 2 years of relevant employment experience in the field of drug discovery.
  • Effective communication skills, both verbal and written.
  • Ability to work in a fast-paced environment.
  • Experience with computer software relevant to laboratory research and data interpretation.

Senior Scientist (DNA damage and Repair) – Target Discovery and Cancer Biology

POSITION DESCRIPTION

Position: Senior Scientist (DNA damage and Repair)  – Target Discovery and Cancer Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining proprietary, high throughput, CRISPR‐enabled genome-scale synthetic lethal (SL) screenings for discovery of targets and patient selection biomarkers with high‐resolution protein crystallography, computational biology and clinical informatics. Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We have an outstanding opportunity available at our Montreal site for a motivated and accomplished Ph.D.-level senior scientist who would like to get in early and grow with the company. The successful candidate will have a thorough background in at least one of the following research areas: DNA damage and repair, genomic instability, cell cycle control and/or synthetic lethality. The candidate will become a vital member of our biology team where he/she will contribute both experimentally and intellectually to validate targets identified from genome-wide synthetic lethal screens and the delivery of our drug discovery pipeline.  The goal is to identify and validate novel patient centric cancer drug targets and deliver drug candidates to benefit patients in the clinic.

RESPONSIBILITIES

  • Establish expertise and maintain a thorough understanding of DNA damage and repair, cancer biology, synthetic lethality, and genome engineering.
  • Utilize CRISPR/CAS9 and other genetic tools to identify and validate novel patient centric cancer drug targets
  • Plan and execute experiments to uncover the mechanism of action for SL interactions
  • Support drug discovery efforts from assay development to continued validation of the drug target throughout the project lifecycle
  • Facilitate the development of computational biology tools by working closely with the bioinformatics team
  • Support in vivo pharmacology and translational science personnel in clinical strategy development (i.e. biomarkers, patient selection criteria, etc.)
  • Close collaboration with the CRISPR platform, drug discovery teams and external investigators

 

QUALIFICATIONS

  • Ph.D. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, or related fields with postdoctoral and 5+ years experience in DNA damage and repair pathways, genomic instability and/or cell cycle control
  • Deep understanding and experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockouts, point mutants, and knock-in cell lines
  • Industry experience is highly desired
  • Expertise in cell and molecular biology techniques is required (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment
  • Experience in pre-clinical drug discovery is an asset

 

Senior Scientist (Epigenomics and Chromatin Remodelling) – Target Discovery and Cancer Biology

POSITION DESCRIPTION

Position: Senior Scientist (Epigenomics and Chromatin Remodelling) – Target Discovery and Cancer Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining proprietary, high throughput, CRISPR‐enabled genome-scale synthetic lethal (SL) screenings for discovery of targets and patient selection biomarkers with high‐resolution protein crystallography, computational biology and clinical informatics. Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We now have an outstanding opportunity available at our Montreal site for a motivated and accomplished Ph.D.-level senior scientist who would like to get in early and grow with the company. The successful candidate will have a thorough understanding of the role of chromatin structure in the regulation of genome integrity and DDR regulation as it relates to cancer biology.  In specific, the candidate will have expertise in at least one of the following research areas: nucleosome remodelling, histone variant exchange, non-histone protein mobility and/or histone post-translational modification.  The candidate will become a vital member of our biology team where he/she will contribute both experimentally and intellectually to validate targets identified from genome-wide synthetic lethal screens and the delivery of our drug discovery pipeline.  The goal is to identify and validate novel patient centric cancer drug targets and deliver drug candidates to benefit patients in the clinic.

 

RESPONSIBILITIES

  • Establish expertise and maintain a thorough understanding of the role of chromatin structure in the regulation of genome integrity and DDR regulation in cancer
  • Utilize CRISPR/CAS9 and other genetic tools to identify and validate novel patient centric cancer drug targets
  • Plan and execute experiments to uncover the mechanism of action for SL interactions
  • Support drug discovery efforts from assay development to continued validation of the drug target throughout the project lifecycle
  • Facilitate the development of computational biology tools by working closely with the bioinformatics team
  • Support in vivo pharmacology and translational science personnel in clinical strategy development (i.e. biomarkers, patient selection criteria, etc.)
  • Close collaboration with the CRISPR platform, drug discovery teams and external investigators

 

QUALIFICATIONS

  • Ph.D. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, or related fields with post-doctoral training and 5+ years experience in the regulation of chromatin remodelling and in epigenetic proteomics and/or epigenetic gene regulation pathways.
  • Deep understanding and experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockouts, point mutants, and knock-in cell lines.
  • Experience in industry is highly desired.
  • Expertise in cell and molecular biology techniques is required (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment
  • Experience in pre-clinical drug discovery is an asset
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