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At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Computational biologist

 

POSITION DESCRIPTION

Position: Computational biologist

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com/news).  Repare develops next generation, precision oncology drugs that target specific vulnerabilities of tumor cells in clearly defined patient populations.  Founded by leading experts at the forefront of DNA damage and repair (DDR) cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a motivated and accomplished computational scientist.  The successful candidate will work closely with biologists, chemists, and translational scientists to impact critical decisions across all stages of drug R&D, from target identification, patient stratification to clinical development.  If you are aspired to become an expert of drug discovery and development, experienced in generating novel insights by combining biology and analysis of genome-scale large data, and savvy with computational techniques in statistics and mathematics,  you will thrive in our team-oriented, fast-paced, dynamic environment!

Job title will depend on the experience of the candidate.

Responsibilities:

–  Collaborate with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based oncology drug discovery

–  Apply and develop computational, statistical, and machine learning methods to mine multi-dimensional genome-scale data sets and derive biological insights

–  Execute integrative analysis of cancer omics, clinical information and functional genomic data to support prioritization of targets and stratification of patients

–  Perform systematic analysis to characterize the landscape and natural history of DDR pathways in human cancer

–  In collaboration with discovery and translational science teams, propose testable hypotheses and experimental verification plans to support program decisions

–  Acts as an expert consultant and scientific resource on computational and statistical topics

 

Qualifications:

–  PhD in Computational Biology, System Biology, Bioinformatics, or related fields

–  3+ years of post-graduate working experience in oncology drug discovery and/or translational setting

–  Solid understanding of cellular and molecular biology and cancer biology.  Experience on DNA Damage and Repair is highly desirable

–  Strong hands-on programing skills (R, Python, Unix, SQL, etc)

–  Solid understanding of probability and statistics

–  Experience with network-based systems biology platforms and methodologies is highly desirable

Oncology translational scientist

 

POSITION DESCRIPTION

Position: Oncology translational scientist

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” startup backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com).  Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells in clearly stratified patient populations.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a highly motivated, independent and experienced oncology translational scientist who would like to get in early and grow with the company. As a founding member of the Translational Science team, the successful candidate will significantly impact the design and execution of translational strategies on assets in early stages of drug discovery and development, including indication selection, developing and implementing biomarker strategies, and delivering fit-for-purpose, clinical biomarker assays for clinical trials.

Job title will depend on the experience of the candidate.

Responsibilities

 

  • Develop indication selection and translational science strategies for lead assets in close collaboration with discovery and clinical teams
  • Partners with discovery team to lead, plan, and execute activities at CROs or academic collaborators to deliver key experimental studies that identify biomarkers for mechanism of action/resistance, target engagement, patient stratification, as well as early signs of efficacy (e.g., ctDNA)
  • Lead development and validation of fit-for-purpose pharmacodynamic and patient selection assays for incorporation into clinical trials
  • Work with clinical operations team to deploy biomarker assays to clinical sites/CROs prior to clinical trials and manage execution of assays and logistics of clinical sample handling during clinical trials
  • Interpret biomarker-related results emerging from tumors, assay development and clinical trials, communicating key findings internally and externally
  • Author biomarker sections and contribute to the generation of regulatory documents (e.g., IB, IND, clinical protocols, study reports)
  • Monitor emerging technologies and pilot new technologies for potential clinical utility in collaboration with discovery biology and clinical teams
  • Establish biobank of human tissues to support indication selection, assessment of biomarker variability, and assay validation

 

Qualifications

 

  • PhD in molecular oncology, molecular/cell biology, biochemistry, or genomics with relevant post-doctoral training
  • 3+ years industry experience in an oncology translational science role (biomarker identification and assay development, etc.)
  • Deep knowledge in tumor biology and DNA repair pathways

Expert understanding of biomarker assay platforms (e.g. IHC, NGS, qPCR) and their applications in clinical trials

Senior Research Scientist – Pharmacology

POSITION DESCRIPTION

Position: Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combinations of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships, therapeutic window and performing mechanism-of-action studies.

 

RESPONSIBILITIES

  • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
  • To identify and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
  • To research, identify and develop relevant pharmacodynamic markers to monitor compound target engagement in vivo.
  • To develop pharmacodynamic assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR or other means.
  • To harvest tumor and tissue samples from treated animals and establish PK/PD and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
  • To conduct drug PK/PD modeling to optimize dose/scheduling and therapeutic window.
  • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

 

  • MSc or PhD in biological sciences and minimum of 3 years relevant experience.
  • Experience in oncology, DNA repair and/or chromatin remodelling is essential.
  • A strong background in cell biology and quantitative cell-based assay development using various modalities is essential.
  • Diverse experience in cell and molecular biology techniques to monitor PK/PD relationships is essential.
  • Experience in pre-clinical drug discovery in an industrial setting is an asset.
  • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models is an asset.
  • Experience with pharmacodynamic modelling software is an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, documentation etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

Research Scientist - DMPK

POSITION DESCRIPTION

Position: Research Scientist – DMPK

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

We now have an outstanding opportunity available at our Montreal site for a motivated and accomplished ADME/DMPK scientist who would like to get in early and grow with the company. The successful candidate will have a thorough, hands-on background in drug metabolism and pharmacokinetics.  A demonstrated expertise performing in vitro techniques with LCMS analysis is needed.  A critical component of the job will be the close collaboration with internal drug discovery teams and CROs.

 

RESPONSIBILITIES

  • Develop, validate and execute novel ADME/DMPK assays.
  • Utilize in vitro and analytical tools to elucidate metabolic and elimination mechanisms for new chemical entities.
  • Review large amounts of data to select appropriate compounds for assay screening.
  • Plan and execute experiments to support progression of projects.
  • Contribute intellectually to drug development programs.
  • Support pharmacokinetic studies and in vivo pharmacology with mass spectrometry based bioanalytical measurements.

 

QUALIFICATIONS

  • MSc. in Chemistry, Biochemistry or related fields with experience in ADME/DMPK in an industrial setting.
  • Expertise in drug metabolism, assay development and pharmacokinetics.
  • Experience in planning and executing in vitro DMPK assays such as hepatocyte stability, metabolite identification, CYP inhibition, protein binding, permeability, solubility and stability.
  • Experience in bioanalytical mass spectrometry and metabolite identification is highly desired.
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment
  • Experience in pre-clinical drug discovery is an asset

Senior Scientist - Cell Cycle

POSITION DESCRIPTION

Position: Senior Scientist – Cell Cycle

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology, drug discovery and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare Therapeutics is a 2017 “Fierce 15” start-up backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com).

 

Repare Therapeutics is seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal cancer therapies. The individual should have extensive knowledge in cell cycle biology, apoptosis, DNA repair/cancer biology, microscopy-based assay development/optimization and biochemistry-related techniques. The scientist should provide expertise in designing cell-based assays and be able to conduct experiments aimed at understanding the mechanisms of action of lead compounds in support of lead identification and lead optimization activities. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

 

RESPONSIBILITIES

  • Establish an expertise and maintain a thorough understanding of cell cycle biology, apoptosis, DNA damage and repair and cancer biology.
  • Develop cell-based readouts (medium to high throughput) for our drug discovery programs using FACS, cell sorting, high content imaging, microscopy, cell proliferation assays (clonogenic, Incucyte, WST1/MTT, BrdU, EdU etc.) and apoptosis-related assays (caspase 3, Annexin-5, TUNEL etc.)
  • Plan and execute experiments to understand the mechanisms of action of lead compounds
  • Execute experiments in a timely, efficient, and independent manner
  • Present clearly and succinctly in a variety of internal settings
  • Good organizational and time-management skills including the ability to manage several projects simultaneously
  • Excellent team work approach – work as part a cross-functional team including biologists, medicinal chemists and structural biologists

 

QUALIFICATIONS

  • M.Sc. + 7 years or Ph.D./Postdoc + 3 years relevant experience in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, or related fields
  • Deep understanding and experience in cell cycle biology, apoptosis, cell proliferation, cancer biology and DNA repair are required
  • Expertise in cell and molecular biology techniques needed (proliferation assays, microscopy, cytogenetics, high content imaging, PCR, immunoblotting, etc.)
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact
  • Experience in pre-clinical drug discovery is an asset
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