Join us

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Director/Global Alliance Management

POSITION DESCRIPTION

 

Position: Associate Director/Global Alliance Management

Company: Repare Therapeutics (Nasdaq: RPTX)

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

 

Overview

Repare is seeking an Associate Director to join its Business Development and Global Alliance Management team in Cambridge, MA.  The Associate Director will report to the Head, Business and Corporate Development and will be responsible for maximizing the success, value and efficiency of our platform and programs by providing leadership in developing and maintaining key partnerships. This position will participate in developing, evolving and coordinating Repare’s overarching strategy for managing partnerships, from business development stages through the partnership life cycle.

 

About Repare

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by our proprietary synthetic lethality approach to the discovery and development of novel therapeutics. We utilize our genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair.  Our pipeline includes our lead product candidate RP-3500, a potential leading ATR inhibitor, as well as CCNE1-SL inhibitor and Polθ inhibitor programs. We anticipate filing an investigational new drug, or IND, application in the second quarter of 2020 and initiating an open-label Phase 1/2 clinical trial of RP-3500 in the third quarter of 2020, enrolling patients based on the presence of alterations in ATM or additional SNIPRx®-identified sensitizing genetic alterations.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

Alliance Management is an integral component of Repare’s Business Development (BD) and Research & Development (R&D) operations. Alliance Management is the key point of contact with external partners to ensure the success of our collaborations by managing the relationships and contractual aspects of each collaboration and plays a central role with R&D, BD, and alliance teams at Repare.

 

Join us to make a difference

We hire the best people and provide them with a fun work environment that places a premium on excellence, diversity, integrity, collaboration and personal development. We proudly promote a culture of inclusion to create a better, more productive work environment. We believe that diversity in experience and perspective drives innovation and transformative business results. If you’re looking to be a part of a company with an unwavering commitment to improving patients’ lives, we encourage you to explore career opportunities at Repare.

 

Position Summary

The Associate Director, Global Alliance Management is responsible for managing and optimizing the value of Repare’s alliances at all stages of the product life cycle, from discovery platform to clinical and commercial. Alliances range from industry partnerships to academic collaborations, clinical and diagnostics partnering.  The position is based in Cambridge, MA.

The Associate Director, Global Alliance Management will be responsible for engaging internal and partner leaders at all levels to maximally leverage collaborations for both the company and its partners. The goal is to enable alliances to deliver results consistent with strategic goals and to enhance Repare’s relationships to secure the company’s reputation as a “Partner of Choice”.

The Associate Director Alliance Management is a cross-functional leader who has either materially contributed to or directly managed life sciences partnerships (specifically license transactions, collaborations, alliances, and/or joint ventures) and has experience with the drug development process, clinical development, diagnostics, and big pharma and/or biotech experience. He/she will be responsible for ensuring that all terms of partnership agreements are adhered to by both parties and that Repare is ultimately perceived as a “Partner of Choice” while upholding the best interests of Repare. The role also requires anticipating and addressing contract and business issues with our alliance partners.  The Associate Director, Global Alliance Management is an individual who can create value through the effective leadership and management of strategic partnerships by working closely with a diverse set of internal and external stakeholders across geographies and functions, coordinating cross-functional activities with internal workgroups across R&D, Business Development, Project Management, Legal and Finance functions.

 

RESPONSIBILITIES

  • Plans and manages the operational aspects of the alliance, including joint governance committee, ensuring alliance effectiveness, appropriate communications, coordination of activities, managing escalation, solving business problems, and negotiating with the partner on ongoing agreements.
  • Provides a single point-of-contact for partners for coordinating business/contractual issue resolution or other business-related matters with partners.
  • Develops strong working relationships with key involved parties for each project, internally and externally, including business development/alliance management, R&D, finance and legal teams.
  • Works with project team leaders and project management preparing for collaboration launch; initial joint project team meetings.
  • Educates team members on contract terms, obligations, milestones and roles and responsibilities.
  • Attends joint team meetings and/or on-site collaborator visits to stay abreast of joint team progress and tracking to contractual obligations.
  • Proactively monitors all aspects of alliance execution, identifying potential issues and taking the lead to resolve them; gaining internal alignment and taking accountability for resolution with partner.
  • Proactively tracks, monitors, and communicates contract milestones, obligations, and any financial payments to project team leaders and management. Works with project team leaders to ensure that both Repare and its alliance partners, are on track to meet contractual obligations and milestones.
  • Monitors and manages execution of contract renewals and amendments.
  • Understands Repare strategies, objectives, and goals related to collaborations and associated capabilities.
  • Stays abreast of internal and external developments, trends, benchmarks, and dynamics. Regularly evaluates current and future opportunities within current alliances/collaborators. Identifies new, enhanced or revised capabilities as appropriate to maximize partnership value.
  • Assists in the development of internal tools, systems, processes, and best practices for the smooth operation of the alliance management function.
  • Enters all key contract information into departmental systems and databases for proactive and efficient tracking of Repare and collaborator obligations.
  • Provides supplemental support for BD operations as warranted, including direct involvement across the continuum of BD activities.

 

QUALIFICATIONS

  • PhD, MD or equivalent advanced degree preferred (MBAs with strong scientific background will be considered).
  • At least 5 years of Biotech/Pharmaceutical industry or Biopharma-specific Management Consulting experience at a top-tier firm, and a minimum of 1 year in an alliance management or similar multi-stakeholder project management role, ideally in a Big Pharma or Biotech environment.
  • Broad understanding of global pharmaceutical and biotech industries, with a solid understanding of drug discovery and development processes, BD, and regulatory, and familiarity with commercial, manufacturing and legal aspects.
  • Organized and proactive problem solver: demonstrated leadership, influence skills, creativity, and ability to manage complexity in identifying and addressing issues, finding and driving to solutions.
  • Cross-functional experience is essential as this position requires a high degree of interaction with teams and senior leadership spanning BD, R&D, finance and legal.
  • Highly collaborative and proactive, with strong interpersonal skills, with a track record of building and maintaining cross-functional working relationships, and able to communicate effectively with team and senior management.
  • Demonstrated ability to adapt and flex in a fast-paced environment and operate independently on both strategic and tactical levels with little to no day-to-day direct supervision of work.
  • High EQ, with poise and tact in conflict situations and ability to keep an objective perspective and exercise proactive diplomacy in all interactions.
  • Ability to work on multiple alliances, initiatives, and projects at any given time.
  • Strong verbal and written communication and computer skills: e.g., proficiency in MS PowerPoint, Excel, Word.
  • Working familiarity with data management and collaboration tools (e.g., videoconferencing (e.g. Zoom, WebEx, virtual data rooms, Sharepoint).
  • Ability to travel and work some off business hours.

Head of Regulatory Affairs & Quality Assurance

POSITION DESCRIPTION

Position: Head of Regulatory Affairs & Quality Assurance

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA or Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Director/Senior Director of Regulatory Affairs & QA at Repare that will oversee the global strategy and execution of the regulatory affairs objectives for the organization providing regulatory strategies for company’s regulatory applications at all stages of development. Ensuring that all activities within the organization are conducted according to the appropriate internal and external quality standards, and that there is adherence to all applicable regulatory requirements. Interfacing with Clinical to ensure studies are following global guidelines and establishing phase-appropriate RA/QA practices and procedures and overseeing their effective and efficient implementation.

Leading and promoting the organization’s philosophy in quality of development and services and in maintaining a work environment that fosters learning, open communication, collaboration, integration, and teamwork. This position will serve as lead for all aspects of Regulatory Affairs and Quality Assurance with emphasis on compliance with GMP, GLP and GCP requirements and standards. The Director/Senior Director will identify, recruit, and manage staff within Regulatory Affairs and external consultants as needed.

 

RESPONSIBILITIES

  • Develops clinical and diagnostic regulatory strategies for all Repare programs in development.
  • Coordinates, writes, compiles, as appropriate, document packages for regulatory submissions from development, manufacturing, preclinical and clinical areas per regulations/guidelines and company SOPs to support regulatory applications.
  • Oversee the establishment, maintenance, and successful implementation of Regulatory & Quality processes and procedures.
  • Develop, Lead, and manage a Regulatory function that complies with appropriate regulations and guidelines and demonstrates operational efficiency.
  • Reviews and approves investigator site regulatory documents (i.e. investigator documents, Informed Consents, IRB/EC documents) according to US FDA requirements and/or country requirements for initiation of clinical sites and drug shipments.
  • Ensure all interactions with Agency personnel (US/Ex-US) are conducted to the highest degree of professionalism.
  • Establish credibility and confidence with key internal and external colleagues through regular communication and the highest degree of professionalism.
  • Create effective team resource plans, structures and processes (including quality management) and institute appropriate SOPs.
  • Lead and manage quality programs which instill personal accountability for accuracy, consistency, and completeness for all operations and departments.
  • Manage key relationships and strategic discussion with large pharmaceutical partners, ensuring program advancement, quality discussions, and desirable outcomes.
  • Ensure Company maintains audit-ready status and lead/support any investigations.
  • Represent RA/QA, both staff and function, at the Repare Cross-functional Leadership Team (XLT) and R&D Leadership Team.
  • Ensure that suppliers and external vendors meet all applicable requirements through the development, implementation, and execution of the Supplier Audit program.
  • Develop and execute the RA/QA operating budget and manage department efforts to control costs.

 

QUALIFICATIONS

  • Minimum 10 years combined experience in Regulatory Affairs & Quality.
  • Minimum 5 years of experience in regulatory oncology in a leadership capacity.
  • Excellent working knowledge of US and EU regulations and guidelines.
  • Successful regulatory filings associated with full life-cycle development: IND/NDA/MAA CTA, amendments, and experience with companion diagnostics are an absolute must.
  • Minimum of a bachelor’s degree in a life science required. MS or PhD degree is preferred.
  • Proven ability to find and create solutions for problems in an innovative way.
  • Strong influencing skills and the ability to build strong interpersonal relationships.
  • Superb oral and written communication skills with the proven ability to shape and frame to diverse audiences.
  • Well-developed interpersonal and problem-solving skills with demonstrated leadership and organizational skills.

Head of Quality Assurance

 

POSITION DESCRIPTION

Position: Head of Quality Assurance

Company: Repare Therapeutics

Location: Cambridge, MA, USA / Remote

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are currently seeking a Head of Quality Assurance that will lead the creation, management, and continuous improvement of Repare’s quality management system (QMS) by collaborating and developing strong relationships internally and partnerships externally to ensure appropriate processes, systems, and activities are in place to protect the rights, safety, and welfare of study subjects.

KEY RESPONSIBILITIES

  • Develop, implement and manage a comprehensive quality management system (QMS) that will ensure QA oversight of internal and external activities including current good manufacturing, clinical, laboratory, and distribution practices (i.e., GXP)
  • Ensure compliance with domestic and international current quality guidelines and GXP regulations
  • Ensure clinical and commercial drug products are manufactured, tested, released, and distributed in accordance with Repare’s established specifications, procedures, clinical requirements, and appropriate GXP standards
  • Develop and implement a GXP vendor quality management program, including vendor audits and quality agreements
  • Provide periodic reports to Senior Management regarding the performance, effectiveness, and strategies for continuous improvement of the QMS
  • Manage internal audits, Quality Risk Management. and continuous improvements
  • Define strategic Quality initiatives and drive organizational change
  • Prepare, lead, and present annual Management Review to Senior Management
  • Develop and implement processes to prepare for and manage regulatory agency inspections

 

QUALIFICATIONS

  • Bachelor’s degree in a scientific discipline is required. An advanced degree in a scientific discipline is preferred
  • Minimum of 10 years of progressive responsibility in pharmaceutical/biotech GXP-related Quality environments
  • 8+ years direct and indirect management level experience
  • In-depth working knowledge of GXPs
  • Leads by example and highly collaborative with the proven ability to work in a cross-functional internal and external teams
  • Communication skills: must be able to lead, manage, and complete GXP quality projects in a fast-paced, growing environment
  • Must be able to prioritize work effectively to ensure progression of multiple department and corporate timelines
  • Must be able to efficiently utilize the computer hardware and software programs provided to plan, manage, conduct and track deliverables.
  • Pro-active in identifying opportunities along with strong problem solving and negotiation skills

 

Research Scientist - Pharmacology

POSITION DESCRIPTION

Position: Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combinations of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed efficacy, PK/PD relationships and therapeutic window.

 

RESPONSIBILITIES

  • To identify, develop and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
  • To maintain and expand cancer cell lines in culture in preparation for tumor inoculation.
  • To prepare drug formulations and dosing solutions.
  • To carry out all aspects of animal experimentation including tumor inoculations, drug administrations (multiple routes), animal health monitoring, anesthesia, surgeries, blood samplings (multiple routes), necropsies, and to monitor tumor progression through a variety of modalities including caliper measurements and luminescence imaging.
  • To perform necropsies, terminal bleeds and tumor and tissue sample harvest from treated animals for the purposes of identifying drug-target engagement and monitoring tumor and tissue PK.
  • To maintain detailed laboratory notes, sample records and protocols. To compile, summarize and graph data for presentations.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

  • DEC in Animal Health Technology, BSc., or MSc in biological sciences with at least 2yrs of relevant experience. A background in oncology is a definite asset.
  • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models including tumor implantation and measurement is essential.
  • Experience in drug administration by multiple routes (e.g. i.v., s.c, p.o., i.p.), tissue perfusion and blood sampling by multiple routes is essential.
  • Experience in pre-clinical drug discovery in an industrial, GLP setting (CRO or other) is an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, etc.).
  • Bilingual French/English (spoken and written) is an asset.
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

 

Senior Research Scientist - Pharmacology

 

POSITION DESCRIPTION

Position: Senior Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an experienced scientist at our Montreal site to assume both a leadership and hands-on role as part of a scientific team responsible for advancing Repare’s drug and target discovery pipelines.  The scientist will develop and characterize both immunocompromised and syngeneic mouse models in which to validate novel cancer drug targets using various gene editing technologies.  They will be involved in assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds and evaluate drug combinations with targeted agents and immuno-oncology therapeutics.

 

RESPONSIBILITIES

  • To identify and implement clinically relevant rodent tumor models in which to evaluate the in vivo efficacy of novel anticancer compounds and perform target validation studies.
  • To implement various genetic knock-out technologies in vivo, in tumor models, for the purposes of target validation.
  • To design and execute experiments to evaluate the efficacy, PK/PD relationships and toxicity of candidate drug compounds and drug combinations in the selected in rodent cancer models.
  • To evaluate target engagement and mechanism of action from in vivo tumor samples.
  • To represent pharmacology at pre-clinical drug development project team meetings.
  • To communicate results at project team and other meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

  • MSc or PhD in biological sciences and minimum of 3 years experience in rodent models of cancer.
  • Experience in small animal handling, including drug administration and blood sampling through multiple routes, necropsies, and minor surgery is essential.
  • Experience in oncology, immune-oncology, DNA repair and/or chromatin remodelling is essential.
  • In vitro techniques such as cell culture, ELISA, western blotting, IHC and FACS analysis are a definite asset.
  • Experience in pre-clinical drug discovery, preferably in an industrial setting an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, documentation etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Bilingual French/English (spoken and written) is an asset.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

 

Research Scientist – Target Discovery

 

POSITION DESCRIPTION

Position: Research Scientist – Target Discovery

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We now have an outstanding opportunity available for a motivated research scientist who would like to get in early and grow with the company. The successful candidate will be an expert in at least one of the following research areas: DNA repair, epigenetics, cancer biology, cell/molecular biology, synthetic lethality, immuno-oncology, and/or genome engineering. The candidate will become a vital member of our SNIPR® platform team where he/she will contribute both experimentally and intellectually to design and execute new SL campaigns and to generate a pool of validated drug targets to advance our portfolio. A critical component of the job will be the close collaboration with internal drug discovery and computational biology teams.

 

RESPONSIBILITIES

  • Become a crucial technical leader on our SNIPRx® target discovery platform
  • Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate and characterize cell line models for SL screens, target validation, and mechanism of action studies
  • Design and execute CRISPR-enabled genome-wide screens
  • Fully characterize cancer cell line panels: expanding, banking, and confirming loss-of-function or gain-of-function gene mutations by sequencing, qPCR, immunoblotting, and functional assays
  • Apply skill set to identify and fully validate new SL targets
  • Plan and execute experiments to uncover mechanisms underlying SL interactions
  • Facilitate the development of computational biology tools by working closely with our bioinformatics team

QUALIFICATIONS

  • M.Sc. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, Immunology or related fields
  • Theoretical or hands-on experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockout and knock-in cell lines
  • Experience in functional genomics (especially RNAi or CRISPR screens) would be an asset
  • Expertise in cell and molecular biology techniques required (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
  • Experience in lentiviral or retroviral packaging and cell line transductions would be an asset
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact

Senior Scientist – Target Discovery

 

POSITION DESCRIPTION

Position: Senior Scientist – Target Discovery

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We now have an outstanding opportunity available for a motivated research scientist who would like to get in early and grow with the company. The successful candidate will be an expert in at least one of the following research areas: DNA repair, epigenetics, cancer biology, cell/molecular biology, synthetic lethality, immuno-oncology, and/or genome engineering. The candidate will become a vital member of our SNIPRx® platform team where he/she will contribute both experimentally and intellectually to design and execute new SL campaigns and to generate a pool of validated drug targets to advance our portfolio. A critical component of the job will be the close collaboration with internal drug discovery and computational biology teams.

 

RESPONSIBILITIES

  • Become a crucial intellectual and technical leader on our SNIPRx® target discovery platform
  • Stay up to date on current literature and attend conferences to establish yourself as a key opinion leader within the company
  • Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate and characterize cell line models for SL screens, target validation, and mechanism of action studies
  • Design and execute CRISPR-enabled genome-wide screens
  • Fully characterize cancer cell line panels: expanding, banking, and confirming loss-of-function or gain-of-function gene mutations by sequencing, qPCR, immunoblotting, and functional assays
  • Apply skill set to identify and fully validate new SL targets
  • Plan and execute experiments to uncover mechanisms underlying SL interactions
  • Facilitate the development of computational biology tools by working closely with our bioinformatics team

QUALIFICATIONS

  • M.Sc. with >10 years relevant experience or Ph.D. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, Immunology or related fields
  • Theoretical or hands-on experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockout and knock-in cell lines
  • Experience in functional genomics (especially RNAi or CRISPR screens) is highly desired
  • Expertise in cell and molecular biology techniques required (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
  • Experience in lentiviral or retroviral packaging and cell line transductions would be an asset
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact

Laboratory Technician – Biology

 

POSITION DESCRIPTION

Position:Laboratory Technician – Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We now have an outstanding opportunity available for a motivated cell and molecular biologist. The candidate will be responsible for the management of our biology laboratories supporting both our drug discovery and SNIPRx® platform teams.

 

RESPONSIBILITIES

  • Tissue culture facility management: biosafety cabinet and incubator maintenance, cell line expansion, mycoplasma testing, banking, and confirming loss-of-function or gain-of-function gene mutations by sequencing, qPCR, immunoblotting, and functional assays
  • Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate and characterize cell line models
  • Aid in the execution CRISPR-enabled genome-wide SL screens with other scientists
  • Production and management of lentiviral stocks
  • Management of biology lab inventory (ordering, stocking, and organizing)
  • Maintain Repare reagent databases (cell lines, plasmids, antibodies, etc.)
  • Manage laboratory equipment maintenance, service, software updates, and new training
  • Oversee ongoing cell and molecular biology projects at various CROs
  • Onboarding of new laboratory personnel

 

QUALIFICATIONS

  • B.Sc. or M.Sc. in biology or related fields
  • >1 year experience in tissue culture required
  • Experience in cell and molecular biology techniques (cloning, DNA/RNA extractions, PCR, qPCR, immunoblotting, microscopy etc.)
  • Experience in lentiviral or retroviral packaging and cell line transductions would be an asset
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner. Bilingualism is a strong asset
  • Outstanding organizational and time management skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact

Research Scientist – Enzymology

 

POSITION DESCRIPTION

Position: Research Scientist – Enzymology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal (SL) cancer therapies. The individual should have extensive knowledge in enzymology, assay development/ optimization and biochemistry-related techniques. The scientist should provide expertise in designing biochemical assays and be able to conduct experiments aimed at biophysical characterization of lead compounds in support of lead ID/Opt activities. The candidate will lead part of a drug discovery program and oversee assay execution capabilities (internally & outsourced). Expertise in cell culture is an asset. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

 

RESPONSIBILITIES

  • Perform enzyme kinetic analyses and MOA studies to characterize diverse biological enzyme systems, including kinases, polymerases & various DNA repair enzymes.
  • Design and develop medium-to-high throughput biochemical (ie. enzymatic, binding) microplate assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including FP, FRET, TR-FRET, BRET, HRTF, mass spectrometric, chromogenic, luminescence and radiometric.
  • Apply a range of biochemical and biophysical techniques to characterize the molecular interaction of novel small molecules with their protein target(s), including radiolabeled binding assays, fluorescence polarization assay, differential scanning fluorimetry (or thermal shift assay), surface plasmon resonance (SPR/Biacore) and isothermal titration calorimetry (ITC)
  • Develop assays using purified-component and cell-based systems configured to identify authentic small-molecule modulators and predict their activity in vivo.
  • Work closely with project teams and external CROs to deploy biochemical assays for high-throughput screening and to drive SAR development.
  • Oversee outsourcing of recombinant protein production & assay development to external CROs and monitor results
  • Execute experiments in a timely, efficient, and independent manner
  • Present clearly and succinctly in a variety of internal settings
  • Good organizational and time-management skills including the ability to manage several projects simultaneously
  • Excellent teamwork approach – work as part a cross-functional team including biologists, medicinal chemists and structural biologists

QUALIFICATIONS

  • PhD or M.Sc. in Biochemistry or related discipline with strong background in enzyme kinetics. Biopharmaceutical industry experience is highly preferred
  • Advanced knowledge and demonstrable track record in enzymology and enzyme inhibitor mechanism-of-action studies
  • Skilled in data analysis and interpretation of various enzyme kinetic models
  • Knowledge of biophysical methods for enzyme studies (e.g. UV/VIS/Fluorescence spectrometry, Mass Spectrometry, Fluorescence polarization)
  • Industrial experience in developing robust enzyme-based assays to support HTS or medicinal chemistry efforts with a successful record of compound progression is an asset
  • Skilled in data analysis and reporting (IC50, EC50, assay variability assessment etc.)
  • Strong understanding of protein expression & purification systems
  • Experience with computer software relevant to laboratory research and data interpretation
  • Effective communicate skills, both verbally and written
  • Ability to work in a fast-paced and team-oriented environment

Senior Scientist - Chemistry

 

POSITION DESCRIPTION

Position: Senior Scientist, Chemistry

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are currently looking for a candidate to join our dynamic medicinal chemistry research team as a Senior Scientist. The selected applicant is an experienced medicinal chemist with established scientific leadership skills in drug discovery. The position requires effective communication skills and leadership experience working with internal and external scientific teams.  The candidate must combine excellent laboratory skills, knowledge of contemporary synthetic methods and ability to work effectively in a multidisciplinary environment.  The ideal candidate is a proven leader who can influence colleagues via his/her technical knowledge and strategic thinking and enjoy a fast-paced and hands-on research environment.

 

KEY RESPONSIBILITIES

  • Design small molecules inhibitors of target proteins with desired drug-like properties that meet a specified target compound profile.
  • Interpret SAR with a clear understanding of relevant biological and ADME data.
  • Provide direct scientific leadership of a team of internal and external chemists to meet program objectives.
  • Participate in the development of scientific goals for specific programs.
  • Interact with molecular modelling, biology and DMPK colleagues to help form program strategy.
  • Execute multi-step, complex organic syntheses in a timely, efficient, and independent manner.

EDUCATION/EXPERIENCE

  • Ph.D. degree in Organic Chemistry
  • A minimum of 5 years of relevant employment experience in the field of drug discovery.
  • Effective communication skills, both verbal and written.
  • Ability to work in a fast-paced environment.
  • Experience with computer software relevant to laboratory research and data interpretation.

Scientist – In vitro/In vivo Biology

 

POSITION DESCRIPTION

Position: Scientist – In vitro/In vivo Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combination strategies of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships and performing mechanism-of-action studies.

 

RESPONSIBILITIES

    • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
    • To participate in cancer target validation in vitro and in vivo through the use of inducible genetic knockdown technologies.
    • To maintain and expand cancer cell lines in culture in preparation for tumor inoculation.
    • To prepare drug formulations and dosing solutions.
    • To carry out animal experimentation including tumor inoculations, drug administrations (multiple routes), animal health monitoring, anesthesia, blood samplings (multiple routes), necropsies, and to monitor tumor progression through a variety of modalities including caliper measurements and luminescence imaging.
    • To implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
    • To implement and carry out pharmacodynamic assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR or other means.
    • To harvest tumor and tissue samples from treated animals to help establish PK/PD and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
    • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
    • To maintain detailed laboratory notes and protocols.
    • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

QUALIFICATIONS

    • MSc or PhD in biological sciences and minimum of 3 years relevant experience.
    • Experience in oncology, DNA repair and/or chromatin remodelling.
    • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models.
    • A strong background in cell biology and quantitative cell-based assay development using various modalities.
    • Diverse experience in cell biology and biochemical techniques to monitor PK/PD relationships.
    • Experience in pre-clinical drug discovery in an industrial setting is an asset.

Compound Manager - Chemistry

 

POSITION DESCRIPTION

Position: Compound Manager, Chemistry

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are currently looking for a candidate to join our dynamic chemistry research team as a Compound Manager. The candidate will play a pivotal role in maintaining a productive and collaborative working environment in our department. The selected applicant must combine excellent laboratory skills, logistical and multitasking skills and ability to work effectively in a multidisciplinary environment.

 

KEY RESPONSIBILITIES

  1. Manager of Repare compound management system
    • Register newly acquired molecules from vendors and CRO’s on computer software
    • Prepare, distribute and organize solution and solid samples of compounds according to their respective project
    • Support compound screening by retrieving and distributing samples to colleagues across department
  1. Manage laboratory consumables and chemical store
    • Monitor and maintain adequate quantities of laboratory consumables
    • Register and distribute purchased reagents
    • Manage chemical store by update data base of reagents and location
    • Prepare commonly used aqueous solutions
  1. Oversee instruments maintenance
    • Monitor and maintain adequate quantities of buffers and solutions to support HPLC’s and purification system
    • Perform weekly maintenance of various instruments
    • Coordinate with suppliers and vendors the preventive maintenance and repair of instruments

4.  Participate in the early discovery process by purifying, characterizing and registering newly acquired molecules for vendors

Additional responsibilities may be assigned based on the experience level of the candidate.

 

REQUIRED QUALIFICATIONS

B.Sc. or M.Sc. in chemistry with lab experience in organic chemistry

PREFERRED QUALIFICATIONS

  • Ability to work in a fast-paced environment.
  • Well-organize individual with multi-tasking ability.
  • Experience with computer software relevant to laboratory research.
  • Willingness to learn and develop additional skillsets

Clinical Biomarker Lead, Oncology Synthetic Lethality

POSITION DESCRIPTION

Position: Clinical Biomarker Lead, Oncology Synthetic Lethality

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Clinical Biomarker Lead that will be accountable for delivery of robust, scientifically driven biomarkers in drug development programs for synthetic lethal drug targets in oncology. This individual will have the opportunity to impact an industry-leading portfolio of Synthetic Lethal Drug Programs from inception of drug candidate and throughout clinical development.

 

RESPONSIBILITIES

  • Identify, develop and implement cutting edge science and technological advances into biomarker and companion diagnostic (CDx) strategies to guide indication selection, patient enrichment, and combination strategies.
  • Develop translational analysis plan and ensure its seamless incorporation into clinical study design and alignment with clinical study objectives. Measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules.
  • Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.
  • Define novel mechanisms of resistance targeted therapies by studying tumors at relapse
  • Provide input to clinical teams on biomarker-related elements of study trial design and conduct and incorporating biomarkers into clinical protocols, lab manuals and consent forms
  • Provide scientific expertise and technical guidance to enable timely biomarker sample collection.
  • Execute sample testing plan and deliver high quality biomarker data packages to inform clinical development and regulatory strategy. Point contact for resolving study biomarker issues.
  • Manage effective working relationships with clinical operations, clinical science, biology leads, bioinformatics and regulatory functions.
  • Establish and manage external collaborations with leading academic groups, diagnostic partners, and CROs.
  • Contribute to scientific credibility of company through contributions to the scientific literature (publications/presentations).

 

QUALIFICATIONS

  • Ph.D. in a life scientific discipline
  • 3-5 years in biotechnology, pharmaceutical industry or clinical setting in the application of biomarkers in clinical trials preferably in oncology biomarker development.
  • Extensive experience in the development of clinical biomarkers with a proven track record of success.
  • Highly experienced in oncology translational research on molecularly targeted therapies, with proven track record of high-impact contributions to biomarker discovery and/or assay development.
  • Experience in conducting clinical trials, conducting biomarker analyses on various clinical sample types and working as part of a clinical study team.
  • Up to date knowledge and deep understanding of major molecular and genomic assay technologies and platforms.
  • Experience with developing and validating fit for purpose clinical assays
  • Having a strong sense of urgency and excellent skills in prioritization, planning as well as timely execution in a very fast-paced environment.
  • Strong interpersonal skills and ability to thrive in a matrix environment.
  • Experience in managing research collaborations, contract laboratories and budgets.
  • Dependable and trustworthy, willing to take ownership and responsibility.

Manager/Associate Director of Toxicology

 

POSITION DESCRIPTION

Position: Manager/Associate Director of Toxicology

Company: Repare Therapeutics

Location: Cambridge, MA, USA / Remote

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

The Manager/Associate Director of Toxicology reports to the Head of Nonclinical Development and serves as an integral contributor to all the preclinical and clinical development projects at Repare.

 

KEY RESPONSIBILITIES

  • Partner with Head of Nonclinical Development, Program Team leaders and R&D staff to lead and manage the toxicology studies for all the Repare programs
  • Provide due-diligence and strategic regulatory advice/evaluations for oncology drug development programs
  • Develop and execute toxicology/regulatory activities from discovery through late stage clinical development programs
  • Prepare the submission of regulatory documents and participate in face-to-face or telecon meetings with regulatory authorities
  • Provide drug safety assessment and manage CROs (selection, evaluations and monitoring)

 

QUALIFICATIONS

  • Bachelor’s degree in a scientific discipline is required. An advanced degree in a scientific discipline is preferred
  • Strong organizational skills
  • Superior communication skills (both written and oral) and attention to detail
  • Experienced and skilled in preparation and review of regulatory documents ( i.e., IND, IB, NDA, MAA)
  • In-depth working knowledge of GXPs
  • Leads by example and highly collaborative with the proven ability to work in a cross-functional internal and external teams
  • Must be able to prioritize work effectively to ensure progression of multiple department and corporate timelines
  • Pro-active in identifying opportunities along with strong problem solving and negotiation skills

 

Receiving Clerk

POSITION DESCRIPTION

 

Position: Receiving Clerk

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a receiving clerk at our Montreal site to manage the receiving of shipments of lab supplies, reagents and equipment; shipping of samples domestically and internationally; support the scientific teams by keeping them stocked of common lab supplies; and be responsible for health and safety procedures required in common areas of our office and laboratory.

This is a full-time permanent position, starting on September 1st, 2020.

 

RESPONSIBILITIES

 

  • Receive shipments at 7120 Frederick-Banting, mark as received in the purchasing system, and distribute to the appropriate scientist in the appropriate manner.
  • Manage inventory of routine lab supplies for Biology, Platform Team, Chemistry and DMPK, including restocking shelves as appropriate and reordering at the appropriate cadence.
  • Be responsible for Repare’s external shipments using FedEx, World Courier or similar, including ensuring appropriate paperwork, scheduling the pickup, ensuring the appropriate packaging and tracking of the package to ensure timely delivery.
  • Complete all required safety training courses as communicated by your superiors or the Repare safety officer.
  • Comply with all required health and safety procedures when handling the various packages of lab supplies and materials.
  • Clean door handles, kitchen surfaces and other common areas three times per day per the company’s decontamination policy.
  • Support the Biology and Platform Group teams in their common lab duties as instructed by the Director of Biology (or delegate thereof), including but not limited to cleaning and wiping down common space and equipment, filling ethanol carboys and keeping the water pans and water baths clean and full.
  • Support the Chemistry team with chemical inventory including solvents, and chemical disposal (both of these under the appropriate supervision by a member of the Chemistry department).

 

QUALIFICATIONS

 

  • Strong communication, organizational and problem-solving skills required.
  • Bilingual French/English (spoken and written) is an asset.
  • Basic computer skills are required (MS Office, Outlook)
  • Experience working in a research laboratory environment is an asset.
  • Experience in shipping and receiving is an asset.
  • Knowledge of shipping chemical or biological samples internationally is an asset.
  • Scientific background is an asset.
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

Pharmacology Internship

POSITION DESCRIPTION

Position: Pharmacology Internship

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an animal technician at our Montreal site for a summer internship.  The successful candidate will assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in the formulation and evaluation of candidate anti-cancer compounds.

 

RESPONSIBILITIES

  • To prepare drug formulations and dosing solutions.
  • To carry out basic aspects of compound evaluation in vivo including, drug administrations (mainly po), animal health monitoring, body weight, food consumption, clinical signs, anesthesia, blood samplings (multiple routes), necropsies, and to monitor tumor progression using calipers.
  • To perform necropsies, terminal bleeds and tumor and tissue sample harvest from treated animals for the purposes of identifying drug-target engagement and monitoring tumor and tissue PK.
  • To maintain detailed laboratory notes, sample records and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

  • Current 2nd year student or completed DEC in Animal Health Technology
  • Experience in small animal handling, preferentially in mice.
  • Experience in drug administration by multiple routes (e.g. i.v., s.c, p.o., i.p.), and blood sampling by multiple routes.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.
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