Join us

At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Bioinformatician

POSITION DESCRIPTION

 

Position: Bioinformatician

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a motivated and accomplished bioinformaticians.  The successful candidate will work closely with biologists, chemists, and translational scientists to impact critical decisions across all stages of drug R&D, from target identification, patient stratification to clinical development.  If you are aspired to become an expert of drug discovery and development, experienced in generating novel insights by combining biology and analysis of genome-scale large data, and savvy with computational techniques in statistics and mathematics,  you will thrive in our team-oriented, fast-paced, dynamic environment!

Job title will depend on the experience of the candidate.

 

RESPONSIBILITIES

  • Collaborate with and support discovery and translational teams by helping design experiments and analyze genomic datasets
  • Collaborate with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based oncology drug discovery
  • Apply and develop computational, statistical, and machine learning methods to mine multi-dimensional genome-scale data sets and derive biological insights
  • Execute integrative analysis of cancer omics, clinical information and functional genomic data to support prioritization of targets and stratification of patients
  • In collaboration with discovery and translational science teams, propose testable hypotheses and experimental verification plans to support program decisions
  • Acts as an expert consultant and scientific resource on computational and statistical topics

QUALIFICATIONS

  • PhD in Bioinformatics, Computational Biology, System Biology, or related fields
  • Solid understanding of cellular and molecular biology. Experience on cancer biology and/or DNA Damage and Repair is highly desirable
  • Experience working closely with biology teams to design and analyze experiments.
  • Strong hands-on programing skills (R, Python, Unix, SQL, etc)
  • Solid understanding of probability and statistics. Experience analyzing genomics datasets. Gene expression, copy number, DNA mutations preferred.
  • Familiarity with large genomic datasets such as the Cancer Dependency Map, The Cancer Genome Atlas, Genotype-Tissue Expression (GTEx)
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment
  • Experience in pre-clinical drug discovery is an asset

Senior Research Scientist – Pharmacology

POSITION DESCRIPTION

 

Position: Senior Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combinations of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships, therapeutic window and performing mechanism-of-action studies.

 

RESPONSIBILITIES

 

  • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
  • To represent pharmacology at pre-clinical drug development project team meetings.
  • To design and plan identify and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
  • To research, identify and develop relevant pharmacodynamic markers to monitor compound target engagement in vivo.
  • To harvest tumor and tissue samples from treated animals and establish PK/PD and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
  • To conduct drug PK/PD modeling to optimize dose/scheduling and therapeutic window.
  • To communicate results at project team and other meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

 

QUALIFICATIONS

 

  • MSc or PhD in biological sciences and minimum of 5 years relevant experience.
  • Experience in pre-clinical drug discovery in an industrial setting is essential.
  • Experience in small animal handling, including drug administration and blood sampling through multiple routes, necropsies, and minor surgery is essential.
  • Experience in carrying out pre-clinical rodent oncology models and harvesting tumor and/or other tissues for PK/PD evaluation is an asset.
  • Experience in oncology, DNA repair and/or chromatin remodelling is a definite asset.
  • Experience with pharmacodynamic modelling software is an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, documentation etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.
Browse...

PDF Only, Maximum size 10MB

Please wait...