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At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Bioinformatician

POSITION DESCRIPTION

 

Position: Bioinformatician

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

Repare currently has an outstanding opportunity available for a motivated and accomplished bioinformaticians.  The successful candidate will work closely with biologists, chemists, and translational scientists to impact critical decisions across all stages of drug R&D, from target identification, patient stratification to clinical development.  If you are aspired to become an expert of drug discovery and development, experienced in generating novel insights by combining biology and analysis of genome-scale large data, and savvy with computational techniques in statistics and mathematics,  you will thrive in our team-oriented, fast-paced, dynamic environment!

Job title will depend on the experience of the candidate.

 

RESPONSIBILITIES

  • Collaborate with and support discovery and translational teams by helping design experiments and analyze genomic datasets
  • Collaborate with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based oncology drug discovery
  • Apply and develop computational, statistical, and machine learning methods to mine multi-dimensional genome-scale data sets and derive biological insights
  • Execute integrative analysis of cancer omics, clinical information and functional genomic data to support prioritization of targets and stratification of patients
  • In collaboration with discovery and translational science teams, propose testable hypotheses and experimental verification plans to support program decisions
  • Acts as an expert consultant and scientific resource on computational and statistical topics

QUALIFICATIONS

  • PhD in Bioinformatics, Computational Biology, System Biology, or related fields
  • Solid understanding of cellular and molecular biology. Experience on cancer biology and/or DNA Damage and Repair is highly desirable
  • Experience working closely with biology teams to design and analyze experiments.
  • Strong hands-on programing skills (R, Python, Unix, SQL, etc)
  • Solid understanding of probability and statistics. Experience analyzing genomics datasets. Gene expression, copy number, DNA mutations preferred.
  • Familiarity with large genomic datasets such as the Cancer Dependency Map, The Cancer Genome Atlas, Genotype-Tissue Expression (GTEx)
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment
  • Experience in pre-clinical drug discovery is an asset

Head of Regulatory Affairs & Quality Assurance

POSITION DESCRIPTION

Position: Head of Regulatory Affairs & Quality Assurance

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA or Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

We are seeking a Director/Senior Director of Regulatory Affairs & QA at Repare that will oversee the global strategy and execution of the regulatory affairs objectives for the organization providing regulatory strategies for company’s regulatory applications at all stages of development. Ensuring that all activities within the organization are conducted according to the appropriate internal and external quality standards, and that there is adherence to all applicable regulatory requirements. Interfacing with Clinical to ensure studies are following global guidelines and establishing phase-appropriate RA/QA practices and procedures and overseeing their effective and efficient implementation.

Leading and promoting the organization’s philosophy in quality of development and services and in maintaining a work environment that fosters learning, open communication, collaboration, integration, and teamwork. This position will serve as lead for all aspects of Regulatory Affairs and Quality Assurance with emphasis on compliance with GMP, GLP and GCP requirements and standards. The Director/Senior Director will identify, recruit, and manage staff within Regulatory Affairs and external consultants as needed.

 

RESPONSIBILITIES

  • Develops clinical and diagnostic regulatory strategies for all Repare programs in development.
  • Coordinates, writes, compiles, as appropriate, document packages for regulatory submissions from development, manufacturing, preclinical and clinical areas per regulations/guidelines and company SOPs to support regulatory applications.
  • Oversee the establishment, maintenance, and successful implementation of Regulatory & Quality processes and procedures.
  • Develop, Lead, and manage a Regulatory function that complies with appropriate regulations and guidelines and demonstrates operational efficiency.
  • Reviews and approves investigator site regulatory documents (i.e. investigator documents, Informed Consents, IRB/EC documents) according to US FDA requirements and/or country requirements for initiation of clinical sites and drug shipments.
  • Ensure all interactions with Agency personnel (US/Ex-US) are conducted to the highest degree of professionalism.
  • Establish credibility and confidence with key internal and external colleagues through regular communication and the highest degree of professionalism.
  • Create effective team resource plans, structures and processes (including quality management) and institute appropriate SOPs.
  • Lead and manage quality programs which instill personal accountability for accuracy, consistency, and completeness for all operations and departments.
  • Manage key relationships and strategic discussion with large pharmaceutical partners, ensuring program advancement, quality discussions, and desirable outcomes.
  • Ensure Company maintains audit-ready status and lead/support any investigations.
  • Represent RA/QA, both staff and function, at the Repare Cross-functional Leadership Team (XLT) and R&D Leadership Team.
  • Ensure that suppliers and external vendors meet all applicable requirements through the development, implementation, and execution of the Supplier Audit program.
  • Develop and execute the RA/QA operating budget and manage department efforts to control costs.

 

QUALIFICATIONS

  • Minimum 10 years combined experience in Regulatory Affairs & Quality.
  • Minimum 5 years of experience in regulatory oncology in a leadership capacity.
  • Excellent working knowledge of US and EU regulations and guidelines.
  • Successful regulatory filings associated with full life-cycle development: IND/NDA/MAA CTA, amendments, and experience with companion diagnostics are an absolute must.
  • Minimum of a bachelor’s degree in a life science required. MS or PhD degree is preferred.
  • Proven ability to find and create solutions for problems in an innovative way.
  • Strong influencing skills and the ability to build strong interpersonal relationships.
  • Superb oral and written communication skills with the proven ability to shape and frame to diverse audiences.
  • Well-developed interpersonal and problem-solving skills with demonstrated leadership and organizational skills.

Senior Research Scientist – biochemical & cellular assays

POSITION DESCRIPTION

Position: Senior Research Scientist – biochemical & cellular assays

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology, drug discovery and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare Therapeutics is a 2017 “Fierce 15” start-up backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com).

 

Repare Therapeutics is seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal cancer therapies. The individual should have extensive knowledge in developing and running biochemical &/or cell-based assays to support lead identification and lead optimization activities. A good understanding of assay miniaturization and automation is needed. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

 

RESPONSIBILITIES

  • Independently develop complex target-based assays in both biochemical and/or cell-based systems to support structure-activity relationship (SAR) studies on various target screens
  • Program and use specialized equipment (ie. plate readers, robotic reagent dispensing) for assay miniaturization needs
  • Knowledge of enzymology and protein-protein interaction is an asset
  • Establish procedures for new assays and be responsible for calculating and reporting data and procedures in an electronic lab book
  • Critically analyze and interpret data using various software, and effectively document and communicate results to a variety of audiences
  • Execute a wide array of technical methods including molecular biology (cloning, PCR, QPCR, western blot) and/or cell culture
  • Good organizational and time-management skills including the ability to manage several projects simultaneously
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact

 

QUALIFICATIONS

  • MSc or PhD Degree in cell biology, molecular biology, biotechnology or biochemistry;
  • At least 5 years of experience in drug discovery in a pharmaceutical/ biotechnology/contract research organization setting (CRO)/ academic platform
  • Strong knowledge and experience in data analysis and reporting is required
  • Hands-on experience with miniaturization and automation is a must
  • Strong analytical capabilities with understanding of early drug discovery is essential
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Excellent teamwork approach – work as part a cross-functional team including biologists, medicinal chemists and structural biologists
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