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At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Senior Scientist - Pharmacology

POSITION DESCRIPTION

 

Position: Senior Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” drug discovery company backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining a proprietary, high throughput, CRISPR‐enabled drug target discovery platform with an experienced team of small molecule drug discovery scientists, structural and computational biologists.  Founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We are seeking an experienced senior scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combination strategies of Repare drug candidates with targeted agents and with immuno-oncology therapeutics for selected agents, establishing detailed PK/PD relationships and performing mechanism-of-action studies.

 

RESPONSIBILITIES

  • To identify and implement clinically relevant rodent models to evaluate the in vivo efficacy of novel anticancer compounds.
  • To research and develop relevant pharmacodynamic markers to monitor compound efficacy in vivo.
  • To maintain and expand cancer cell lines in culture in preparation for tumor inoculation.
  • To carry out all aspects of animal experimentation including tumor inoculations, drug administrations, animal health monitoring, anesthesia, surgeries, blood samplings, necropsies, and to monitor tumor progression through a variety of modalities including luminescence imaging.
  • To undertake mechanistic studies including pharmacodynamic evaluation of candidate compounds in vivo and in vitro using several techniques including western blotting, IHC, ELISA, bead proximity and enzymatic assays.
  • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

  • MSc or PhD in biological sciences and minimum of 5 years relevant experience.
  • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models is essential.
  • Diverse experience in cell and molecular biology techniques to monitor PK/PD relationships is essential.
  • Experience in in pre-clinical drug discovery in an industrial, GLP setting (CRO or other) is an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

Senior Research Scientist - Enzymology

 

POSITION DESCRIPTION

Position Senior Research Scientist – Enzymology (permanent)

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

COMPANY BACKGROUND

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare is backed by tier-one strategic and institutional biotechnology investors with track records for high-impact drug development, including Versant Ventures and MPM Capital.

 

SENIOR RESEARCH SCIENTIST

 

Repare Therapeutics is seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal (SL) cancer therapies. The individual should have extensive knowledge in enzymology, assay development/optimization and biochemistry-related techniques. The scientist should provide expertise in designing biochemical assays and be able to conduct experiments aimed at biophysical characterization of lead compounds in support of lead ID/Opt activities. The candidate will lead part of a drug discovery program and oversee assay execution capabilities (internally & outsourced). Expertise in cell culture is an asset. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

 

 

 

KEY RESPONSIBILITIES

  • Perform enzyme kinetic analyses and MOA studies to characterize diverse biological enzyme systems, including kinases, polymerases & various DNA repair enzymes.
  • Design and develop medium-to-high throughput biochemical (ie. enzymatic, binding) microplate assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including FP, FRET, TR-FRET, BRET, HRTF, mass spectrometric, chromogenic, luminescence and radiometric.
  • Apply a range of biochemical and biophysical techniques to characterize the molecular interaction of novel small molecules with their protein target(s), including radiolabeled binding assays, fluorescence polarization assay, differential scanning fluorimetry (or thermal shift assay), surface plasmon resonance (SPR/Biacore) and isothermal titration calorimetry (ITC)
  • Develop assays using purified-component and cell-based systems configured to identify authentic small-molecule modulators and predict their activity in vivo.
  • Work closely with project teams and external CROs to deploy biochemical assays for high-throughput screening and to drive SAR development.
  • Oversee outsourcing of recombinant protein production & assay development to external CROs and monitor results
  • Execute experiments in a timely, efficient, and independent manner
  • Present clearly and succinctly in a variety of internal settings
  • Good organizational and time-management skills including the ability to manage several projects simultaneously
  • Excellent team work approach – work as part a cross-functional team including biologists, medicinal chemists and structural biologists

 

 

EDUCATION & SKILLS

 

  • PhD + 5yr experience or M.Sc. +8yr experience in Biochemistry or related discipline. Biopharmaceutical industry experience is highly preferred
  • Advanced knowledge and demonstrable track record in enzymology and enzyme inhibitor mechanism-of-action studies
  • Significant experience in developing robust enzyme-based assays to support high-throughput screening or medicinal chemistry efforts with a successful record of compound progression
  • Skilled in data analysis and reporting (IC50, EC50, assay variability assessment etc.)
  • Strong understanding of protein expression & purification systems
  • Experience with computer software relevant to laboratory research and data interpretation
  • Effective communicate skills, both verbally and written
  • Ability to work in a fast-paced and team-oriented environment

 

Research Scientist – Biology

 

POSITION DESCRIPTION

Position: Research Scientist – Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics is a 2017 “Fierce 15” start-up backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com). Repare develops novel precision oncology drugs that target specific vulnerabilities of tumor cells. This is accomplished by combining proprietary CRISPR‐enabled genome-wide synthetic lethal (SL) screens for target discovery and patient selection biomarkers with high‐resolution protein crystallography, computational biology and clinical informatics. Founded by leading experts at the forefront of DNA damage and repair, cancer biology, and high-throughput CRISPR screening technologies, Repare has assembled a seasoned team of industry veterans and a world-class Advisory Board.

 

We now have an outstanding opportunity available for a motivated M.Sc. or Ph.D.-level research scientist who would like to get in early and grow with the company. The successful candidate will have experience in at least one of the following research areas: DNA repair, epigenetics, cancer biology, synthetic lethality, and/or genome engineering. The candidate will become a vital member of our SL platform team where he/she will contribute both experimentally and intellectually to design and execute new SL campaigns and to generate a pool of completely validated drug targets to advance our portfolio. A critical component of the job will be the close collaboration with internal drug discovery teams and external investigators.

 

RESPONSIBILITIES

  • Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate and characterize cell line models for SL screens, target validation, and mechanism of action studies
  • Design and execute CRISPR-enabled genome-wide SL screens
  • Fully characterize cancer cell line panels: expanding, banking, and confirming loss of function or gain of function gene mutations by sequencing, qPCR, immunoblotting, and/or functional assays
  • Apply skill set to identify and fully validate new SL targets
  • Plan and execute experiments to uncover mechanisms underlying SL interactions
  • Facilitate the development of computational biology tools by working closely with our bioinformatics team

QUALIFICATIONS

  • M.Sc. or Ph.D. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, or related fields
  • At least 2 years experience in mammalian cell culture
  • Understanding or hands-on experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockouts, point mutants, and knock-in cell lines
  • Experience in functional genomics (especially RNAi or CRISPR screens) is highly desired
  • Expertise in cell and molecular biology techniques needed (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
  • Experience in lentiviral or retroviral packaging and cell line transductions would be an asset
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact
  • Experience in pre-clinical drug discovery is an asset
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