Join us

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

To protect the interests of all parties, Repare Therapeutics will not accept unsolicited resumes from any source other than directly from a candidate. Any unsolicited resumes sent to Repare Therapeutics, including unsolicited resumes sent to a Repare Therapeutics mailing address, email address, or directly to Repare Therapeutics employees, will be considered Repare Therapeutics property. Repare Therapeutics will not pay a fee for any placement resulting from the receipt of an unsolicited resume. Repare Therapeutics will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees.

Recruiting agencies must obtain advance written approval from Repare Therapeutics’ Finance department to submit resumes, and then only in conjunction with a valid fully-executed contract for service and in response to a specific job opening. Repare Therapeutics will not pay a fee to any Agency that does not have such agreement in place.

Associate Director/Global Alliance Management

POSITION DESCRIPTION

 

Position: Associate Director/Global Alliance Management

Company: Repare Therapeutics (Nasdaq: RPTX)

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

 

Overview

Repare is seeking an Associate Director to join its Business Development and Global Alliance Management team in Cambridge, MA.  The Associate Director will report to the Head, Business and Corporate Development and will be responsible for maximizing the success, value and efficiency of our platform and programs by providing leadership in developing and maintaining key partnerships. This position will participate in developing, evolving and coordinating Repare’s overarching strategy for managing partnerships, from business development stages through the partnership life cycle.

 

About Repare

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by our proprietary synthetic lethality approach to the discovery and development of novel therapeutics. We utilize our genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair.  Our pipeline includes our lead product candidate RP-3500, a potential leading ATR inhibitor, as well as CCNE1-SL inhibitor and Polθ inhibitor programs. We anticipate filing an investigational new drug, or IND, application in the second quarter of 2020 and initiating an open-label Phase 1/2 clinical trial of RP-3500 in the third quarter of 2020, enrolling patients based on the presence of alterations in ATM or additional SNIPRx®-identified sensitizing genetic alterations.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

Alliance Management is an integral component of Repare’s Business Development (BD) and Research & Development (R&D) operations. Alliance Management is the key point of contact with external partners to ensure the success of our collaborations by managing the relationships and contractual aspects of each collaboration and plays a central role with R&D, BD, and alliance teams at Repare.

 

Join us to make a difference

We hire the best people and provide them with a fun work environment that places a premium on excellence, diversity, integrity, collaboration and personal development. We proudly promote a culture of inclusion to create a better, more productive work environment. We believe that diversity in experience and perspective drives innovation and transformative business results. If you’re looking to be a part of a company with an unwavering commitment to improving patients’ lives, we encourage you to explore career opportunities at Repare.

 

Position Summary

The Associate Director, Global Alliance Management is responsible for managing and optimizing the value of Repare’s alliances at all stages of the product life cycle, from discovery platform to clinical and commercial. Alliances range from industry partnerships to academic collaborations, clinical and diagnostics partnering.  The position is based in Cambridge, MA.

The Associate Director, Global Alliance Management will be responsible for engaging internal and partner leaders at all levels to maximally leverage collaborations for both the company and its partners. The goal is to enable alliances to deliver results consistent with strategic goals and to enhance Repare’s relationships to secure the company’s reputation as a “Partner of Choice”.

The Associate Director Alliance Management is a cross-functional leader who has either materially contributed to or directly managed life sciences partnerships (specifically license transactions, collaborations, alliances, and/or joint ventures) and has experience with the drug development process, clinical development, diagnostics, and big pharma and/or biotech experience. He/she will be responsible for ensuring that all terms of partnership agreements are adhered to by both parties and that Repare is ultimately perceived as a “Partner of Choice” while upholding the best interests of Repare. The role also requires anticipating and addressing contract and business issues with our alliance partners.  The Associate Director, Global Alliance Management is an individual who can create value through the effective leadership and management of strategic partnerships by working closely with a diverse set of internal and external stakeholders across geographies and functions, coordinating cross-functional activities with internal workgroups across R&D, Business Development, Project Management, Legal and Finance functions.

 

RESPONSIBILITIES

  • Plans and manages the operational aspects of the alliance, including joint governance committee, ensuring alliance effectiveness, appropriate communications, coordination of activities, managing escalation, solving business problems, and negotiating with the partner on ongoing agreements.
  • Provides a single point-of-contact for partners for coordinating business/contractual issue resolution or other business-related matters with partners.
  • Develops strong working relationships with key involved parties for each project, internally and externally, including business development/alliance management, R&D, finance and legal teams.
  • Works with project team leaders and project management preparing for collaboration launch; initial joint project team meetings.
  • Educates team members on contract terms, obligations, milestones and roles and responsibilities.
  • Attends joint team meetings and/or on-site collaborator visits to stay abreast of joint team progress and tracking to contractual obligations.
  • Proactively monitors all aspects of alliance execution, identifying potential issues and taking the lead to resolve them; gaining internal alignment and taking accountability for resolution with partner.
  • Proactively tracks, monitors, and communicates contract milestones, obligations, and any financial payments to project team leaders and management. Works with project team leaders to ensure that both Repare and its alliance partners, are on track to meet contractual obligations and milestones.
  • Monitors and manages execution of contract renewals and amendments.
  • Understands Repare strategies, objectives, and goals related to collaborations and associated capabilities.
  • Stays abreast of internal and external developments, trends, benchmarks, and dynamics. Regularly evaluates current and future opportunities within current alliances/collaborators. Identifies new, enhanced or revised capabilities as appropriate to maximize partnership value.
  • Assists in the development of internal tools, systems, processes, and best practices for the smooth operation of the alliance management function.
  • Enters all key contract information into departmental systems and databases for proactive and efficient tracking of Repare and collaborator obligations.
  • Provides supplemental support for BD operations as warranted, including direct involvement across the continuum of BD activities.

 

QUALIFICATIONS

  • PhD, MD or equivalent advanced degree preferred (MBAs with strong scientific background will be considered).
  • At least 5 years of Biotech/Pharmaceutical industry or Biopharma-specific Management Consulting experience at a top-tier firm, and a minimum of 1 year in an alliance management or similar multi-stakeholder project management role, ideally in a Big Pharma or Biotech environment.
  • Broad understanding of global pharmaceutical and biotech industries, with a solid understanding of drug discovery and development processes, BD, and regulatory, and familiarity with commercial, manufacturing and legal aspects.
  • Organized and proactive problem solver: demonstrated leadership, influence skills, creativity, and ability to manage complexity in identifying and addressing issues, finding and driving to solutions.
  • Cross-functional experience is essential as this position requires a high degree of interaction with teams and senior leadership spanning BD, R&D, finance and legal.
  • Highly collaborative and proactive, with strong interpersonal skills, with a track record of building and maintaining cross-functional working relationships, and able to communicate effectively with team and senior management.
  • Demonstrated ability to adapt and flex in a fast-paced environment and operate independently on both strategic and tactical levels with little to no day-to-day direct supervision of work.
  • High EQ, with poise and tact in conflict situations and ability to keep an objective perspective and exercise proactive diplomacy in all interactions.
  • Ability to work on multiple alliances, initiatives, and projects at any given time.
  • Strong verbal and written communication and computer skills: e.g., proficiency in MS PowerPoint, Excel, Word.
  • Working familiarity with data management and collaboration tools (e.g., videoconferencing (e.g. Zoom, WebEx, virtual data rooms, Sharepoint).
  • Ability to travel and work some off business hours.

Biotransformation Scientist

 

Position: Biotransformation Scientist

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a highly motivated and team-oriented Biotransformation Scientist to join our DMPK department to help optimize our small-molecule cancer therapeutics. The individual should have a thorough, hands-on background in metabolite identification.  A demonstrated expertise with mass spectrometry and in vitro techniques is also required.  The candidate is expected to work in close collaboration with internal drug discovery teams.

RESPONSIBILITIES

  • Apply in vitro and analytical tools to study metabolic and elimination mechanisms for new chemical entities.
  • Use high resolution mass spectrometry elucidate chemical structures and identify metabolic soft spots.
  • Apply additional in vitro DMPK assays to drive compound progression.
  • Plan, optimize and execute experiments to support discovery projects.
  • Contribute intellectually to all drug development programs.

 QUALIFICATIONS

  • Msc. / PhD. in Chemistry, Biochemistry or related fields with several years of experience in ADME/DMPK in an industrial setting.  Recent PhD graduates in a relevant field with a keen interest to further specialize in ADME are encouraged to apply.
  • Experience in one or more of the following fields: metabolite identification, bioanalytical mass spectrometry, organic chemistry, in vitro DMPK assays. A strong understanding of metabolic reaction mechanisms is essential.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (study planning, experimental design, lab notebook keeping)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

Senior Research Scientist - Pharmacology

 

POSITION DESCRIPTION

Position: Senior Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an experienced scientist at our Montreal site to assume both a leadership and hands-on role as part of a scientific team responsible for advancing Repare’s drug and target discovery pipelines.  The scientist will develop and characterize both immunocompromised and syngeneic mouse models in which to validate novel cancer drug targets using various gene editing technologies.  They will be involved in assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds and evaluate drug combinations with targeted agents and immuno-oncology therapeutics.

 

RESPONSIBILITIES

  • To identify and implement clinically relevant rodent tumor models in which to evaluate the in vivo efficacy of novel anticancer compounds and perform target validation studies.
  • To implement various genetic knock-out technologies in vivo, in tumor models, for the purposes of target validation.
  • To design and execute experiments to evaluate the efficacy, PK/PD relationships and toxicity of candidate drug compounds and drug combinations in the selected in rodent cancer models.
  • To evaluate target engagement and mechanism of action from in vivo tumor samples.
  • To represent pharmacology at pre-clinical drug development project team meetings.
  • To communicate results at project team and other meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

  • MSc or PhD in biological sciences and minimum of 3 years experience in rodent models of cancer.
  • Experience in small animal handling, including drug administration and blood sampling through multiple routes, necropsies, and minor surgery is essential.
  • Experience in oncology, immune-oncology, DNA repair and/or chromatin remodelling is essential.
  • In vitro techniques such as cell culture, ELISA, western blotting, IHC and FACS analysis are a definite asset.
  • Experience in pre-clinical drug discovery, preferably in an industrial setting an asset.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, documentation etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Bilingual French/English (spoken and written) is an asset.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

 

Senior Scientist – Target Discovery

 

POSITION DESCRIPTION

Position: Senior Scientist – Target Discovery

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We now have an outstanding opportunity available for a motivated research scientist who would like to get in early and grow with the company. The successful candidate will be an expert in at least one of the following research areas: DNA repair, epigenetics, cancer biology, cell/molecular biology, synthetic lethality, immuno-oncology, and/or genome engineering. The candidate will become a vital member of our SNIPRx® platform team where he/she will contribute both experimentally and intellectually to design and execute new SL campaigns and to generate a pool of validated drug targets to advance our portfolio. A critical component of the job will be the close collaboration with internal drug discovery and computational biology teams.

 

RESPONSIBILITIES

  • Become a crucial intellectual and technical leader on our SNIPRx® target discovery platform
  • Stay up to date on current literature and attend conferences to establish yourself as a key opinion leader within the company
  • Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate and characterize cell line models for SL screens, target validation, and mechanism of action studies
  • Design and execute CRISPR-enabled genome-wide screens
  • Fully characterize cancer cell line panels: expanding, banking, and confirming loss-of-function or gain-of-function gene mutations by sequencing, qPCR, immunoblotting, and functional assays
  • Apply skill set to identify and fully validate new SL targets
  • Plan and execute experiments to uncover mechanisms underlying SL interactions
  • Facilitate the development of computational biology tools by working closely with our bioinformatics team

QUALIFICATIONS

  • M.Sc. with >10 years relevant experience or Ph.D. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, Immunology or related fields
  • Theoretical or hands-on experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockout and knock-in cell lines
  • Experience in functional genomics (especially RNAi or CRISPR screens) is highly desired
  • Expertise in cell and molecular biology techniques required (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
  • Experience in lentiviral or retroviral packaging and cell line transductions would be an asset
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact

Research Scientist – Enzymology

 

POSITION DESCRIPTION

Position: Research Scientist – Enzymology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal (SL) cancer therapies. The individual should have extensive knowledge in enzymology, assay development/ optimization and biochemistry-related techniques. The scientist should provide expertise in designing biochemical assays and be able to conduct experiments aimed at biophysical characterization of lead compounds in support of lead ID/Opt activities. The candidate will lead part of a drug discovery program and oversee assay execution capabilities (internally & outsourced). Expertise in cell culture is an asset. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

 

RESPONSIBILITIES

  • Perform enzyme kinetic analyses and MOA studies to characterize diverse biological enzyme systems, including kinases, polymerases & various DNA repair enzymes.
  • Design and develop medium-to-high throughput biochemical (ie. enzymatic, binding) microplate assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including FP, FRET, TR-FRET, BRET, HRTF, mass spectrometric, chromogenic, luminescence and radiometric.
  • Apply a range of biochemical and biophysical techniques to characterize the molecular interaction of novel small molecules with their protein target(s), including radiolabeled binding assays, fluorescence polarization assay, differential scanning fluorimetry (or thermal shift assay), surface plasmon resonance (SPR/Biacore) and isothermal titration calorimetry (ITC)
  • Develop assays using purified-component and cell-based systems configured to identify authentic small-molecule modulators and predict their activity in vivo.
  • Work closely with project teams and external CROs to deploy biochemical assays for high-throughput screening and to drive SAR development.
  • Oversee outsourcing of recombinant protein production & assay development to external CROs and monitor results
  • Execute experiments in a timely, efficient, and independent manner
  • Present clearly and succinctly in a variety of internal settings
  • Good organizational and time-management skills including the ability to manage several projects simultaneously
  • Excellent teamwork approach – work as part a cross-functional team including biologists, medicinal chemists and structural biologists

QUALIFICATIONS

  • PhD or M.Sc. in Biochemistry or related discipline with strong background in enzyme kinetics. Biopharmaceutical industry experience is highly preferred
  • Advanced knowledge and demonstrable track record in enzymology and enzyme inhibitor mechanism-of-action studies
  • Skilled in data analysis and interpretation of various enzyme kinetic models
  • Knowledge of biophysical methods for enzyme studies (e.g. UV/VIS/Fluorescence spectrometry, Mass Spectrometry, Fluorescence polarization)
  • Industrial experience in developing robust enzyme-based assays to support HTS or medicinal chemistry efforts with a successful record of compound progression is an asset
  • Skilled in data analysis and reporting (IC50, EC50, assay variability assessment etc.)
  • Strong understanding of protein expression & purification systems
  • Experience with computer software relevant to laboratory research and data interpretation
  • Effective communicate skills, both verbally and written
  • Ability to work in a fast-paced and team-oriented environment

Scientist – In vitro/In vivo Biology

 

POSITION DESCRIPTION

Position: Scientist – In vitro/In vivo Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combination strategies of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships and performing mechanism-of-action studies.

 

RESPONSIBILITIES

    • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
    • To participate in cancer target validation in vitro and in vivo through the use of inducible genetic knockdown technologies.
    • To maintain and expand cancer cell lines in culture in preparation for tumor inoculation.
    • To prepare drug formulations and dosing solutions.
    • To carry out animal experimentation including tumor inoculations, drug administrations (multiple routes), animal health monitoring, anesthesia, blood samplings (multiple routes), necropsies, and to monitor tumor progression through a variety of modalities including caliper measurements and luminescence imaging.
    • To implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
    • To implement and carry out pharmacodynamic assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR or other means.
    • To harvest tumor and tissue samples from treated animals to help establish PK/PD and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
    • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
    • To maintain detailed laboratory notes and protocols.
    • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

QUALIFICATIONS

    • MSc or PhD in biological sciences and minimum of 3 years relevant experience.
    • Experience in oncology, DNA repair and/or chromatin remodelling.
    • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models.
    • A strong background in cell biology and quantitative cell-based assay development using various modalities.
    • Diverse experience in cell biology and biochemical techniques to monitor PK/PD relationships.
    • Experience in pre-clinical drug discovery in an industrial setting is an asset.

Clinical Biomarker Lead, Oncology Synthetic Lethality

POSITION DESCRIPTION

Position: Clinical Biomarker Lead, Oncology Synthetic Lethality

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Clinical Biomarker Lead that will be accountable for delivery of robust, scientifically driven biomarkers in drug development programs for synthetic lethal drug targets in oncology. This individual will have the opportunity to impact an industry-leading portfolio of Synthetic Lethal Drug Programs from inception of drug candidate and throughout clinical development.

 

RESPONSIBILITIES

  • Identify, develop and implement cutting edge science and technological advances into biomarker and companion diagnostic (CDx) strategies to guide indication selection, patient enrichment, and combination strategies.
  • Develop translational analysis plan and ensure its seamless incorporation into clinical study design and alignment with clinical study objectives. Measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules.
  • Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.
  • Define novel mechanisms of resistance targeted therapies by studying tumors at relapse
  • Provide input to clinical teams on biomarker-related elements of study trial design and conduct and incorporating biomarkers into clinical protocols, lab manuals and consent forms
  • Provide scientific expertise and technical guidance to enable timely biomarker sample collection.
  • Execute sample testing plan and deliver high quality biomarker data packages to inform clinical development and regulatory strategy. Point contact for resolving study biomarker issues.
  • Manage effective working relationships with clinical operations, clinical science, biology leads, bioinformatics and regulatory functions.
  • Establish and manage external collaborations with leading academic groups, diagnostic partners, and CROs.
  • Contribute to scientific credibility of company through contributions to the scientific literature (publications/presentations).

 

QUALIFICATIONS

  • Ph.D. in a life scientific discipline
  • 3-5 years in biotechnology, pharmaceutical industry or clinical setting in the application of biomarkers in clinical trials preferably in oncology biomarker development.
  • Extensive experience in the development of clinical biomarkers with a proven track record of success.
  • Highly experienced in oncology translational research on molecularly targeted therapies, with proven track record of high-impact contributions to biomarker discovery and/or assay development.
  • Experience in conducting clinical trials, conducting biomarker analyses on various clinical sample types and working as part of a clinical study team.
  • Up to date knowledge and deep understanding of major molecular and genomic assay technologies and platforms.
  • Experience with developing and validating fit for purpose clinical assays
  • Having a strong sense of urgency and excellent skills in prioritization, planning as well as timely execution in a very fast-paced environment.
  • Strong interpersonal skills and ability to thrive in a matrix environment.
  • Experience in managing research collaborations, contract laboratories and budgets.
  • Dependable and trustworthy, willing to take ownership and responsibility.

Pharmacology Internship

POSITION DESCRIPTION

Position: Pharmacology Internship

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an animal technician at our Montreal site for a summer internship.  The successful candidate will assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in the formulation and evaluation of candidate anti-cancer compounds.

 

RESPONSIBILITIES

  • To prepare drug formulations and dosing solutions.
  • To carry out basic aspects of compound evaluation in vivo including, drug administrations (mainly po), animal health monitoring, body weight, food consumption, clinical signs, anesthesia, blood samplings (multiple routes), necropsies, and to monitor tumor progression using calipers.
  • To perform necropsies, terminal bleeds and tumor and tissue sample harvest from treated animals for the purposes of identifying drug-target engagement and monitoring tumor and tissue PK.
  • To maintain detailed laboratory notes, sample records and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

 

QUALIFICATIONS

  • Current 2nd year student or completed DEC in Animal Health Technology
  • Experience in small animal handling, preferentially in mice.
  • Experience in drug administration by multiple routes (e.g. i.v., s.c, p.o., i.p.), and blood sampling by multiple routes.
  • Ability to communicate in an open, clear, timely and consistent manner.
  • Outstanding organizational skills (lab book, experimental design, etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.
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