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At Repare Therapeutics, we are always looking for highly innovative and collaborative individuals who are passionate about discovering revolutionary cancer treatments.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Head, Computational Biology and Bioinformatics

POSITION DESCRIPTION

Position Head, Computational Biology and Bioinformatics

Company Repare Therapeutics

Flexible Location Cambridge, MA, USA or Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

COMPANY BACKGROUND

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare is backed by tier-one strategic and institutional biotechnology investors with track records for high-impact drug development, including Versant Ventures and MPM Capital.

 

HEAD, COMPUTATIONAL BIOLOGY AND BIOINFORMATICS

 

Repare Therapeutics has an outstanding opportunity available for a motivated and highly accomplished scientist to lead our Bioinformatics and Computational Biology activities. This impactful role is responsible for developing our computational strategy in support of high-throughput functional genomics screening, drug target identification and translational genomics projects to enable clinical patient selection. The individual will be responsible to build internal capabilities and leverage external capabilities to interrogate datasets, including next generation sequencing and CRISPR screening data, and will develop tools and analysis strategies to generate hypotheses for target identification/validation and drug discovery. A critical component of the job will be the close collaboration with internal drug discovery teams and external investigators.

 

KEY RESPONSIBILITIES

 

  • Leading the development and implementation of a computational platform for genomics-based target discovery
  • Development of data analysis and management pipelines for high-throughput functional genomics studies across all stages of the process – from automation and QC of raw data processing to the design of databases and developing methods for results interpretation
  • Apply or develop new tools or data-mining techniques for integrative analysis and visualization of multi-dimensional data-sets for target discovery
  • Integrate genomic and experimental data to impact drug discovery projects by developing hypotheses around patient selection and biomarkers
  • A solid understanding of biological processes
  • A solid understanding of bioinformatics databases and software
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner.
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact.
  • Proficiency with R, Python or other scripting language for statistical computing and graphics.

 

EDUCATION

  • D. in Biology, Bioinformatics, Genetics, Statistics, or related field
  • Experience in the area of DNA Damage and Repair is highly desirable
  • A minimum of 7 years of relevant work experience in bioinformatics or computational biology in an academic or industry setting.

 

Associate Director/Director of In Vivo Pharmacology

POSITION DESCRIPTION

Position Associate Director/Director of In Vivo Pharmacology

Company Repare Therapeutics

Location Montreal, Quebec, Canada (Cambridge, MA, USA possible for a highly qualified candidate)

Website http://www.reparerx.com/

 

COMPANY BACKGROUND

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare is backed by tier-one strategic and institutional biotechnology investors with track records for high-impact drug development, including Versant Ventures and MPM Capital.

 

ASSOCIATE DIRECTOR/DIRECTOR OF IN VIVO PHARMACOLOGY

 

Repare Therapeutics is seeking a motivated and team-oriented pharmacology leader to help advance our portfolio of synthetic lethal cancer therapies into clinical development.  The individual will provide exceptional scientific leadership to manage an internal and external team focused on the design and execution of in vivo tolerability, PK/PD and efficacy studies and development of new models to support a robust pipeline of oncology projects.  The role will involve significant interaction and collaboration within the company and experience managing external studies at CROs and academic collaborators. The ideal candidate is a proven leader who can influence colleagues via his/her technical knowledge and strategic thinking.  Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

KEY RESPONSIBILITIES

  • Build an internal in vivo pharmacology team
  • Work with scientist’s cross-functionally to ensure high scientific quality of all in vivo studies
  • Provide strategic and scientific leadership as part of cross-functional research teams
  • Design and interpret in vivo efficacy, PK/PD studies, explore novel therapeutic hypotheses, and investigate mechanism of action for candidate small molecules
  • Manage external projects with contract research organizations, including study design, data and sample management
  • Oversee activities in a shared animal care facility
  • Direct work with external academic and industry collaborators
  • Present clearly and succinctly in a variety of internal and external settings
  • Deep understanding of in vivo oncology pharmacology and a track record of driving research stage programs into the clinic
  • Proven experience with establishing, evaluating, benchmarking, and presenting in vivo models
  • Extensive experience in the design and evaluation of PK/PD studies, drug combination studies, formulation of test compounds, dosing and blood and tissue collection with animal models of cancer
  • Strong scientific writing skills, including the preparation of regulatory submissions (e.g. IND)
  • Excellent organizational and time-management skills including the ability to manage several projects simultaneously
  • A strong record in mentoring and career development of others

 

EDUCATION

 

  • PhD degree in a relevant scientific field, degree in Pharmacology highly desirable
  • A minimum of 5-10 years of relevant work experience in preclinical in vivo pharmacology, translational research, and small molecule drug discovery and development
  • Experience in the area of DNA Damage and Repair is highly desirable
  • Previous biotech or pharma industry experience is desired for the role.

Senior Medicinal Chemist

POSITION DESCRIPTION

Position Senior Medicinal Chemist

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

COMPANY BACKGROUND

 

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare is backed by tier-one strategic and institutional biotechnology investors with track records for high-impact drug development, including Versant Ventures and MPM Capital.

 

SENIOR MEDICINAL CHEMIST

 

Repare Therapeutics is seeking an experienced medicinal chemist to lead an internal drug discovery program.   The position requires strong scientific leadership and communication skills to collaborate with internal scientists and manage an external scientific team.  The selected applicant must combine excellent laboratory skills, knowledge of contemporary synthetic methods and ability to work effectively in a multidisciplinary environment.

The ideal candidate is a proven leader who can influence colleagues via his/her technical knowledge and strategic thinking.  Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

KEY RESPONSIBILITIES

  • Design small molecules inhibitors of target proteins with desired drug-like properties that meet a specified target profile.
  • Execute multi-step, complex organic syntheses in a timely, efficient, and independent manner.
  • Participate in the development of scientific goals for specific programs.
  • Interpret SAR with a clear understanding of relevant biological and ADME data.
  • Interact with molecular modelling, biology and DMPK colleagues to help form program strategy.
  • Provide direct management of a team of external chemists to meet program objectives.

 

EDUCATION/EXPERIENCE

 

  • Ph.D. degree in Organic Chemistry
  • A minimum of 6 years of relevant employment experience in the field of drug discovery.
  • Experience working in the field of kinase inhibitors.
  • Effective communicate skills, both verbal and written.
  • Ability to work in a fast-paced environment.
  • Experience with computer software relevant to laboratory research and data interpretation.
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