Scientific References

Check out the scientific literature that supports our molecular targets and our synthetic lethal approach.

September 2022

Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ

July 2022

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306

July 2022

Guiding ATR and PARP inhibitor combinationswith chemogenomic screens

April 2022

CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition

June 2020

Honing in on PARPi Response in Prostate Cancer: from HR Pathway to Gene-by-Gene Granularity 

May 2020

Identifying functional loss of ATM gene in patients with advanced cancer

February 2020

Analyse pan-cancer de génomes entiers

February 2020

Pan-cancer analysis of whole genomes

January 2020

CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions

We have a number of synthetic lethal therapies in development.