Scientific References
CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition
David Gallo et al. Nature. April 2022
RP-3500: A Novel, Potent and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors
Anne Roulston, et al. Molecular Cancer Therapeutics. 2021
CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition
David Gallo et al. April 2020
Identifying functional loss of ATM gene in patients with advanced cancer.
Patrick Glen Pilie et al. ASCO. 2020
Honing in on PARPi response in Prostate Cancer: from HR pathway- to gene-by-gene granularity
Alexandra O, et al. Clinical Cancer Research. May 1 2020 DOI: 10.1158/1078-0432.CCR-20-0707
Pan-cancer analysis of whole genomes.
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Synthetic lethality as an engine for cancer drug target discovery.
Huang A, Garraway LA, Ashworth A, Weber B. Nat Rev Drug Discov. 2020;19(1):23–38
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CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions.
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A CRISPR Way to Identify Cancer Targets.
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Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
TA Knijnenburg et al. Cell Rep 23 (1), 239-254.e6. 2018
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Synthetic lethality in lung cancer and translation to clinical therapies.
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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.
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The concept of synthetic lethality in the context of anticancer therapy.
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Global mapping of the yeast genetic interaction network.
Tong AH, Lesage G, Bader GD, et al. Science. 2004;303(5659):808–813.