Scientific References Check out the scientific literature that supports our molecular targets and our synthetic lethal approach. October 2023 KRAS alterations combined with TP53 mutations as novel synthetic lethal genomic lesions for PKMYT1 inhibition Marc L. Hyer, Jimmy Fourtounis, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS October 2023 Camonsertib (RP-3500), an ataxia telangiectasia- and Rad3-related kinase inhibitor (ATRi) in combination with low dose gemcitabine (gem) in patients with solid tumors with DNA damage response (DDR) aberrations: Preclinical and Phase 1b results (NCT04497116) Ezra Rosen, Timothy A. Yap, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS October 2023 MYTHIC: First-in-human (FIH) biomarker-driven phase I trial of first-in-class PKMYT1 inhibitor lunresertib (lunre) alone and with ATR inhibitor camonsertib (cam) in solid tumors with CCNE1 amplification or deleterious alterations in FBXW7 or PPP2R1 Timothy A. Yap, Alison Schram, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS October 2023 Retrospective baseline biomarker analyses in a first-in-human Phase 1 trial of the PKMYT1 inhibitor lunresertib (RP-6306) in pts with advanced solid tumors harboring CCNE1 amplification and/or deleterious alterations in FBXW7 or PPP2R1 Elia Aguado-Fraile, Sunantha Sethuraman, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS October 2023 Preclinical development of PKMYT1 and ATR inhibitor combinations David Gallo, Marc L. Hyer, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS October 2023 Preclinical development of PKMYT1 and WEE1 inhibitor combinations David Gallo, Fenil Shah, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS October 2023 Circulating tumor DNA (ctDNA) genomic and epigenomic profiling (GuardantINFINITY) for diagnosis of DNA damage repair (DDR) loss of function (LOF) and response monitoring in the TRESR and ATTACC trials Ezra Rosen, Joseph D. Schonhoft, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS June 2023 Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results Timothy A. Yap, Elisa Fontana, Et Al. Nature Medicine May 2023 Detection of Biallelic Loss of DNA Repair Genes in Formalin-Fixed, Paraffin-Embedded Tumor Samples Using a Novel Tumor-Only Sequencing Panel Dominik Glodzik, Pier Selenica, Et Al. The Journal of Molecular Diagnostics April 2023 Characterization of CCNE1 amplifications and associated genomic features in ovarian and uterine cancers Sunantha Sethuraman, Dominik Glodzik, Et Al. AACR 2023 1234 We have a number of synthetic lethal therapies in development. View Pipeline
