Scientific References Check out the scientific literature that supports our molecular targets and our synthetic lethal approach. April 2022 CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition Gallo D, Young JTF, Fourtounis J, et al. Nature February 2022 RP-3500: A Novel, Potent and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors Roulston A, Zimmermann M, Papp R, et al. Molecular Cancer Therapeutics June 2020 Honing in on PARPi Response in Prostate Cancer: from HR Pathway to Gene-by-Gene Granularity Sokolova AO, Yu EY, Cheng HH Clinical Cancer Research May 2020 Identifying functional loss of ATM gene in patients with advanced cancer Pilie PG, Gheeya JS, Kyewalabye K, et al. ASCO February 2020 Analyse pan-cancer de génomes entiers Consortium ICGC/TCGA pour l'analyse pancancer du génome entier Nature February 2020 Pan-cancer analysis of whole genomes ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium Nature January 2020 CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions Su D, Feng X, Colic M, et al. ScienceDirect November 2019 Synthetic lethality as an engine for cancer drug target discovery Huang A, Garraway LA, Ashworth A, Weber B Nature Reviews Drug Discover June 2019 A CRISPR Way to Identify Cancer Targets Hahn WC New England Journal of Medicine May 2019 First-in-human trial of the oral ataxia telangiectasia and Rad3-related (ATR) inhibitor BAY 1895344 in patients (pts) with advanced solid tumors De Bono JS, Shao DP, Caldwell R, et al. Journal of Clinical Oncology 12 We have a number of synthetic lethal therapies in development. View Pipeline
