CAREERS

Position: Document Control Specialist/Manager

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

Repare Therapeutics is looking for a Document Control Specialist or Manager whose primary responsibility is coordinating Document Control and activities related to the identification, collection, distribution and filing of controlled documents in an FDA regulated environment.  This position supports critical documentation within cross-functional teams and will ensure the integrity of document creation, version control, storage, retrieval, and lifecycle management are effectively implemented.  This position will aid in ensuring that document management is consistent across the organization, while maintaining control and traceability of the documentation history in compliance with GxP regulations.  Key contributions of the role will include writing, revising, and maintaining document control procedures as well as participation in the development and deployment of document control tools.

RESPONSIBILITIES

• Independently manage and monitor the processing, review, and approval of all controlled documents in both electronic document management systems (DMS) and supporting manual systems
• Coordinate the revision process of Standard Operating Procedures (SOPs), forms, and other controlled documents assuring that the corporate and regulatory standards are upheld
• Manage the daily flow and final release of controlled documents through the document management system.
• Continuous improvement of the Document Control program
• Participates in the development and roll-out of document control tools, monitors documentation/Quality Systems function, and coordinates with IT on issues
• Provide user assistance and training on the DMS
• Develops and delivers training regarding document control processes and system changes
• Ensure compliance with controlled document format and content
• Maintain master documents and records (both hardcopy and/or electronic) to ensure documentation is retrievable and files are accurate, complete, and well organized
• Manage the document periodic review process
• Responsible for managing record retention policies and procedures
• Track and communicate company training compliance within multiple departments
• Assist with the development of evolving document control systems
• Maintain SOP, change control, deviation, CAPA, etc. logs contemporaneously
• Assist with generating Quality Document Control metrics as needed
• Represent quality in departmental or team meetings
• Assist Quality Management by performing various tasks in support of the administration and maintenance of Quality Systems
• Represent Quality Assurance as the Subject Matter Expert (SME) for Good Documentation Practices

QUALIFICATIONS

• Bachelor’s degree, Life Sciences preferred, but now required
• Experience in Document Control System and network-based Quality Management Systems
• Worked in an FDA regulated environment
• Minimum of two (2) years QA document control experience
• Proficient in document management systems
• Highly Proficient in Word, Excel, and PowerPoint – Smartsheet and SharePoint are a plus
• Familiar with FDA regulations
• Ability to work effectively on multiple projects simultaneously with minimum supervision
• Strong interpersonal and communication skills
• Able to organize and prioritize work
• Strong written and verbal communication skills
• Effective/concise communicator with management and internal teams
• Experience with working in startup environments moving in rapid growth/manufacturing

Position: Principal Bioinformatician

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Principal Bioinformatician with the passion and desire to become part of a fast-based, innovative team committed to developing breakthrough cancer therapies. The individual will be a self-starter that is effective in working independently as well as a collaborative team member. The successful candidate will help define and implement bioinformatics strategy and mentor junior team members. They will collaborate with members of our SNIPRx® platform team to identify novel synthetic-lethal targets. Furthermore, they will collaborate with translational scientists to help identify patient populations where our drugs are efficacious and effectively lead them into the clinic.

Responsibilities:

• Act as an internal thought leader on data analysis for target discovery and translational efforts
• Mentor junior bioinformatics team members in target discovery, translational bioinformatics, or cancer genomics
• Implement and improve analytical approaches for target and biomarker identification
• Collaborate with and support target discovery and translational teams by helping design experiments and analyze genomic datasets
• Collaborate with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based oncology drug discovery
• Apply and develop computational, statistical, and machine learning methods to mine multi-dimensional genome-scale data sets and derive biological insights
• Execute integrative analysis of cancer omics, clinical information and functional genomic data to support prioritization of targets and stratification of patients
• In collaboration with discovery and translational science teams, propose testable hypotheses and experimental verification plans to support program decisions

Qualifications:

• PhD in Bioinformatics, Computational Biology, System Biology, or related fields
• Work experience
  • Four (4) years or more of bioinformatics research experience in the biotech or pharmaceutical industry, or
  • Six (6) years or more of post-doctoral academic bioinformatics experience in oncology target discovery, oncology translational sciences, or oncology medical genomics
• Desired scientific experience
  • Cancer biology and cancer genomics. Experience with DNA Damage and Repair pathways is desirable.
  • Analysis of large cell line panel data such as CRISPR-Cas9 knockout screens and barcoded drug treatment screens (e.g. PRISM)
  • Familiarity with large genomic datasets such as the Cancer Dependency Map, The Cancer Genome Atlas, Genotype-Tissue Expression (GTEx)
• Experience working closely with biology teams to design and analyze experiments.
• Strong hands-on programing skills (R, Python, Unix, SQL, etc)
• Solid understanding of probability and statistics.
• Management experience highly desirable
• Collaborative team player who is also an independent thinker; ability to develop a strong point of view combined with the openness to evolving that view based on new data and analysis
• Ability to handle multiple projects and utilize judgement to prioritize tasks

Position: Coordinator, Clinical Biomarker Operations (CBO)

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Coordinator, CBO with the passion and desire to become part of a fast-based, innovative team committed to developing breakthrough cancer therapies. This individual will coordinate with translational researchers, clinical operations and PK team members in order to implement and maintain biomarker and clinical sample operational plans. This position requires a combination of scientific and project management expertise as they will be responsible for the support of clinical laboratory functions within clinical trials; Includes operational support for biomarker definition and selection, clinical testing schedules, and lab manual creation.

Responsibilities:

• Manage end-to-end sample tracking and logistics for clinical samples, working closely with the central and specialty lab vendors as well as a sample and data management vendor
• Identify, triage, and resolve biomarker sample queries to ensure sample and data integrity
• Monitor trends and quality metrics as they relate to clinical site sample collection, processing and shipment errors
• Ensure biomarker laboratory documents are filed appropriately in the eTMF
• Maintain biomarker documentation (requisition forms, analysis request forms, redacted patient files, etc.) in an organized manner
• Assist with creating site and team training tools as they relate to clinical biomarker operations
• Liaise with the preclinical teams to help drive translational research projects and ensure timely data delivery

Qualifications:

• Bachelor’s degree with Science focus
• Experience managing clinical labs study startup and oversight
• 1-3 years experience in clinical operations with a focus on clinical laboratory management
• Strong verbal and written communication skills
• Excellent interpersonal and organizational skills
• Ability to deal with competing priorities
• Strong reasoning, detail orientation and problem-solving abilities are essential
• Ability to work on teams and on multiple concurrent projects, and works well under general direction with tight timelines

POSITION DESCRIPTION

Position: Associate Director/Director of Quantitative Pharmacology

Company: Repare Therapeutics

Location: Cambridge, MA, USA / Remote

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

The Associate Director/Director of Quantitative Pharmacology reports to the Head of Nonclinical Development and serves as an integral contributor to all the preclinical and clinical development projects at Repare.

KEY RESPONSIBILITIES

• Partner with Head of Nonclinical Development, Program Team leaders and R&D staff to lead the pharmacometrics and quantitative PK/PD strategy for Repare’s discovery and development programs
• As a member of the Repare’s project teams, the individual will be responsible for applying model-based approaches to support compartmental and mechanism-based PK/PD analysis, evaluation of FIH dose and regimen recommendations.
• Develop and execute strategies for mid-stage and late-stage Oncology programs to support regulatory questions and filings
• Provide due-diligence and strategic regulatory advice/evaluations for oncology drug development programs
• The successful incumbent will utilize a range of computational approaches (PK/PD, PBPK, pharmacometrics, systems-based, informatics). The scope of project responsibility will range from late discovery through registration.

QUALIFICATIONS

• A Ph.D. in Pharmacology, Biology, Engineering, Mathematics or related field with 5+ years of relevant experience in modeling and simulation.
• Excellent understanding of PK (NCA, compartmental) and PK/PD principles.
• Expertise in the application of Phoenix WinNonlin, PBPK related software, and R is required.
• Experience with PopPK model development with regulatory reporting is a plus.
• Superior communication skills (both written and oral) and attention to detail
• Strong organizational skills
• Leads by example and highly collaborative with the proven ability to work in a cross-functional internal and external teams
• Must be able to prioritize work effectively to ensure progression of multiple department and corporate timelines
• Pro-active in identifying opportunities along with strong problem solving and negotiation skills
• A strategic thinker who can generate ideas and opportunities and turn them into successful results

POSITION DESCRIPTION

Position: Senior Research Scientist – Pharmacology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an experienced scientist at our Montreal site to assume both a leadership and hands-on role as part of a scientific team responsible for advancing Repare’s drug and target discovery pipelines.  The scientist will develop and characterize both immunocompromised and syngeneic mouse models in which to validate novel cancer drug targets using various gene editing technologies.  They will be involved in assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds and evaluate drug combinations with targeted agents and immuno-oncology therapeutics.

RESPONSIBILITIES

• To identify and implement clinically relevant rodent tumor models in which to evaluate the in vivo efficacy of novel anticancer compounds and perform target validation studies.
• To implement various genetic knock-out technologies in vivo, in tumor models, for the purposes of target validation.
• To design and execute experiments to evaluate the efficacy, PK/PD relationships and toxicity of candidate drug compounds and drug combinations in the selected in rodent cancer models.
• To evaluate target engagement and mechanism of action from in vivo tumor samples.
• To represent pharmacology at pre-clinical drug development project team meetings.
• To communicate results at project team and other meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
• To maintain detailed laboratory notes and protocols.
• The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
• The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

QUALIFICATIONS

• MSc or PhD in biological sciences and minimum of 3 years experience in rodent models of cancer.
• Experience in small animal handling, including drug administration and blood sampling through multiple routes, necropsies, and minor surgery is essential.
• Experience in oncology, immune-oncology, DNA repair and/or chromatin remodelling is essential.
• In vitro techniques such as cell culture, ELISA, western blotting, IHC and FACS analysis are a definite asset.
• Experience in pre-clinical drug discovery, preferably in an industrial setting an asset.
• Ability to communicate in an open, clear, timely and consistent manner.
• Outstanding organizational skills (lab book, experimental design, documentation etc.).
• Ability to handle multiple projects and utilize judgement to prioritize tasks.
• Bilingual French/English (spoken and written) is an asset.
• Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

POSITION DESCRIPTION

Position: Senior Scientist – Target Discovery

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We now have an outstanding opportunity available for a motivated research scientist who would like to get in early and grow with the company. The successful candidate will be an expert in at least one of the following research areas: DNA repair, epigenetics, cancer biology, cell/molecular biology, synthetic lethality, immuno-oncology, and/or genome engineering. The candidate will become a vital member of our SNIPRx® platform team where he/she will contribute both experimentally and intellectually to design and execute new SL campaigns and to generate a pool of validated drug targets to advance our portfolio. A critical component of the job will be the close collaboration with internal drug discovery and computational biology teams.

RESPONSIBILITIES

• Become a crucial intellectual and technical leader on our SNIPRx® target discovery platform
• Stay up to date on current literature and attend conferences to establish yourself as a key opinion leader within the company
• Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate and characterize cell line models for SL screens, target validation, and mechanism of action studies
• Design and execute CRISPR-enabled genome-wide screens
• Fully characterize cancer cell line panels: expanding, banking, and confirming loss-of-function or gain-of-function gene mutations by sequencing, qPCR, immunoblotting, and functional assays
• Apply skill set to identify and fully validate new SL targets
• Plan and execute experiments to uncover mechanisms underlying SL interactions
• Facilitate the development of computational biology tools by working closely with our bioinformatics team

QUALIFICATIONS

• M.Sc. with >10 years relevant experience or Ph.D. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, Immunology or related fields
• Theoretical or hands-on experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockout and knock-in cell lines
• Experience in functional genomics (especially RNAi or CRISPR screens) is highly desired
• Expertise in cell and molecular biology techniques required (proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
• Experience in lentiviral or retroviral packaging and cell line transductions would be an asset
• Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
• Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
• Ability to handle multiple projects and utilize judgement to prioritize tasks
• Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact

POSITION DESCRIPTION

Position: Research Scientist – Enzymology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal (SL) cancer therapies. The individual should have extensive knowledge in enzymology, assay development/ optimization and biochemistry-related techniques. The scientist should provide expertise in designing biochemical assays and be able to conduct experiments aimed at biophysical characterization of lead compounds in support of lead ID/Opt activities. The candidate will lead part of a drug discovery program and oversee assay execution capabilities (internally & outsourced). Expertise in cell culture is an asset. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

RESPONSIBILITIES

• Perform enzyme kinetic analyses and MOA studies to characterize diverse biological enzyme systems, including kinases, polymerases & various DNA repair enzymes.
• Design and develop medium-to-high throughput biochemical (ie. enzymatic, binding) microplate assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including FP, FRET, TR-FRET, BRET, HRTF, mass spectrometric, chromogenic, luminescence and radiometric.
• Apply a range of biochemical and biophysical techniques to characterize the molecular interaction of novel small molecules with their protein target(s), including radiolabeled binding assays, fluorescence polarization assay, differential scanning fluorimetry (or thermal shift assay), surface plasmon resonance (SPR/Biacore) and isothermal titration calorimetry (ITC)
• Develop assays using purified-component and cell-based systems configured to identify authentic small-molecule modulators and predict their activity in vivo.
• Work closely with project teams and external CROs to deploy biochemical assays for high-throughput screening and to drive SAR development.
• Oversee outsourcing of recombinant protein production & assay development to external CROs and monitor results
• Execute experiments in a timely, efficient, and independent manner
• Present clearly and succinctly in a variety of internal settings
• Good organizational and time-management skills including the ability to manage several projects simultaneously
• Excellent teamwork approach – work as part a cross-functional team including biologists, medicinal chemists and structural biologists

QUALIFICATIONS

• PhD or M.Sc. in Biochemistry or related discipline with strong background in enzyme kinetics. Biopharmaceutical industry experience is highly preferred
• Advanced knowledge and demonstrable track record in enzymology and enzyme inhibitor mechanism-of-action studies
• Skilled in data analysis and interpretation of various enzyme kinetic models
• Knowledge of biophysical methods for enzyme studies (e.g. UV/VIS/Fluorescence spectrometry, Mass Spectrometry, Fluorescence polarization)
• Industrial experience in developing robust enzyme-based assays to support HTS or medicinal chemistry efforts with a successful record of compound progression is an asset
• Skilled in data analysis and reporting (IC50, EC50, assay variability assessment etc.)
• Strong understanding of protein expression & purification systems
• Experience with computer software relevant to laboratory research and data interpretation
• Effective communicate skills, both verbally and written
• Ability to work in a fast-paced and team-oriented environment

POSITION DESCRIPTION

Position: Scientist – In vitro/In vivo Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combination strategies of Repare drug candidates with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships and performing mechanism-of-action studies.

RESPONSIBILITIES

• • The level of position responsibilities will be adjusted according to the candidate’s background and experience level.
  • To participate in cancer target validation in vitro and in vivo through the use of inducible genetic knockdown technologies.
  • To maintain and expand cancer cell lines in culture in preparation for tumor inoculation.
  • To prepare drug formulations and dosing solutions.
  • To carry out animal experimentation including tumor inoculations, drug administrations (multiple routes), animal health monitoring, anesthesia, blood samplings (multiple routes), necropsies, and to monitor tumor progression through a variety of modalities including caliper measurements and luminescence imaging.
  • To implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
  • To implement and carry out pharmacodynamic assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR or other means.
  • To harvest tumor and tissue samples from treated animals to help establish PK/PD and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
  • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

QUALIFICATIONS

• • MSc or PhD in biological sciences and minimum of 3 years relevant experience.
  • Experience in oncology, DNA repair and/or chromatin remodelling.
  • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models.
  • A strong background in cell biology and quantitative cell-based assay development using various modalities.
  • Diverse experience in cell biology and biochemical techniques to monitor PK/PD relationships.
  • Experience in pre-clinical drug discovery in an industrial setting is an asset.

Position: Clinical Trial Manager/Senior Clinical Trial Manager

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Clinical Trial Manager/Senior Clinical Trial Manager with the passion and desire to become part of a fast-based, innovative team committed to developing breakthrough cancer therapies. The individual will be a self-starter that is effective in working independently as well as a collaborative team member. The successful candidate will ensure the Company’s clinical trial(s), in support of its innovative clinical pipeline, are managed to the highest quality to ensure safety and effectiveness of products in adherence with all applicable regulations.

RESPONSIBILITIES

• Leads cross-functional trial team to ensure delivery of complex clinical trials and manages protocol execution.
• Oversees CROs and vendors to ensure timelines, goals and deliverables are met with quality, within budget, and in accordance with SOPs, GCP and all applicable laws and regulations.

• Provides input to the clinical development plan and operational aspects of the clinical trial protocol (e.g., develops and/or reviews operational plans for trials).
• Prepares/reviews site study documents (i.e., site-specific informed consent, study tools/worksheets, investigator contracts, and site payments).
• Identifies and/or anticipates operational risks and mitigation plans within assigned clinical trials and escalates issues and recommends contingency plans to Head of Clinical Operations as necessary.
• Establish study milestones and ensure accurate tracking and reporting of study metrics, timelines, update of trial information in all trial databases and tracking systems.
• Provide monitoring oversight including authoring of oversight plan, reviewing monitoring visit reports and perform periodic oversight visits to sites and/or vendors to assess progress and compliance.
• Manage clinical trial budgets, providing ongoing financial reporting and projections to the finance group and facilitate the development of clinical trial agreements, insurance and other relevant documents in conjunction with legal.
• Ensure the Trial Master File (TMF) is maintained throughout the trial and performs inspection readiness checks throughout the lifecycle of the trial.
• Serves as functional area reviewer of global clinical / regulatory submissions.
• Present study status reports of operational execution activities to senior management.
• Provide study specific mentor and training for in-house Clinical Research Associate(s).
• Participates in operational process improvement initiatives (including, training, SOP review and development of work instructions/tools/templates).
• Performs other duties as assigned

QUALIFICATIONS

• Bachelor’s degree in a life science or a health-related field is preferred, Advanced degree highly preferred
• Five (5) years or more of progressive clinical management experience with the biotech / pharmaceutical industry or in a clinical research organization (oncology experience highly preferred), global trial experience highly preferred
• Solid understanding of the clinical trial database life cycle including, data collection, review and analysis, CRF design, database development and testing, discrepancy management, data quality review and database close and lock procedures
• Strong understanding of FDA/ICH guidelines and industry standard practices regarding clinical trial management
• Excels in a fast-paced, high-growth company environment with minimal direction and a high-degree of independence and able to adjust workload based on changing priorities
• Collaborative team player who is also an independent thinker; ability to develop a strong point of view combined with the openness to evolving that view based on new data and analysis
• Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
• Ability to handle multiple projects and utilize judgement to prioritize tasks
• Ability to contribute as a team member in a dynamic, fast-paced biotech environment

POSITION DESCRIPTION

Position: Information Technology Support Specialist

Company: Repare Therapeutics Inc.

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

The Information Technology Support Specialist reports to the Head of Information Technology (IT) as an integral contributor to provide technical support to operational systems as well as users at Repare.

KEY RESPONSIBILITIES

• Setup, deploy, maintain, and manage user devices (computers, laptops, and mobile phones) as well as applications or services required for the proper operation of these
• Provide quality and timely on-site or remote user technical support
• Maintain help-desk application to develop support activity database
• Monitor and manage capacity and performance data to ensure the optimal operation of company systems and devices
• Promote awareness of information security issues among Repare staff and ensure that they understand and adhere to systems security policies and procedures
• Review system backup logs and assist with the development, implementation, maintenance and improvement of the Repare Data Backup and Disaster Recovery practice
• Assist in the implementation and maintenance of IT back-end systems
• Participate in the development of IT documentation (processes and /or SOPs)
• Participate in various on-going IT projects as required

QUALIFICATIONS

• DEC / BAC in Information Technology or equivalent
• System management experience for the following platforms: Microsoft Windows, Apple MacOS, Active Directory, IOS, and Android
• Strong technical knowledge of Microsoft Office 365 and Office products
• Working experience on support and manage Microsoft SharePoint platform
• Excellent troubleshooting skills related to desktop/laptop computer hardware and software, demonstrating the ability to quickly resolve complex issues or suggest alternative solutions
• Excellent communication skills and ability to work in a growing team environment
• Good knowledge of network security practice and network standards
• Requires occasional lifting of equipment or materials up to 30 lbs
• Demonstrated ability to handle multiple support tasks
• Able to be on-call outside working hours on regular basis
• Able to work outside working hours if needed
• Excellent command of both written and spoken English and French
• Knowledge of MDM and virtual machine is a plus

POSITION DESCRIPTION

Position: Part time In Vivo Animal Technician

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking an animal technician at our Montreal site for part-time work involving weekends and some weekdays (3-4 days per week).  The successful candidate will assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in the formulation and in vivo evaluation of candidate anti-cancer compounds as well as sample collection and processing.

RESPONSIBILITIES

• To prepare drug formulations and dosing solutions.
• To carry out basic aspects of compound evaluation in vivo including, drug administrations (mainly po), animal health monitoring, body weight, food consumption, clinical signs, anesthesia, blood samplings (multiple routes), necropsies, and to monitor tumor progression using calipers.
• To perform necropsies, terminal bleeds and tumor and tissue sample harvest from treated animals for the purposes of identifying drug-target engagement and monitoring tumor and tissue PK.
• To process blood samples for analysis, plasma/serum isolation and hematology analysis.
• To maintain detailed laboratory notes, sample records and protocols.
• To restock and order supplies as needed.
• The successful candidate will be required to work weekends and non-standard hours from time to time, including statutory holidays as required by on-going experiments. A flexible and adaptable schedule is an asset.

QUALIFICATIONS

• Good experience in small animal handling, preferentially in mice.
• Experience with compound formulation preparation
• Experience in drug administration by multiple routes (e.g. i.v., s.c, p.o., i.p.), and blood sampling by multiple routes is essential.
• Experience with in vivo models of oncology an asset.
• Ability to communicate in an open, clear, timely and consistent manner.
• Outstanding organizational skills (lab book, record keeping, etc.).
• Ability to handle multiple projects and utilize judgement to prioritize tasks.
• Ability to contribute as a team member in a dynamic, fast-paced biotech environment.