CAREERS

Position Operations Manager, Facilities

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as RP-6306, a first-in-class inhibitor for CCNE1-amplified tumors, and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

Repare is seeking an Operations Manager to join its team in Montreal.  The Operations Manager will manage day-to-day responsibilities of the facilities, including space panning and design, oversee shipping/receiving, and liaise with building management. The Operations Manager will have excellent bilingual (French and English) verbal and written communication, organization skills, project management skills, and creative problem-solving skills. The candidate must have a high level of professionalism, be capable of working independently and be willing to take accountability and ownership of issues and concerns to drive exceptional results.

What You’ll Do

• Develop and implement a best-in-class facilities operations plan including developing processes, continuous improvement initiatives and tools to enhance space planning and utilization that reflects company growth projections, strategic milestones and future expansion.
• Continually assess business and operational risk associated with existing and future facilities and develop mitigation and maintenance strategies to address these risks.
• Oversee all operational and planning aspects of facilities management including maintenance and repair, functions and building systems.
• Take responsibility for optimizing all shipping and receiving activities on site including inventory management and supervision of shipping/receiving staff.
• Work with vendors and landlords to ensure Repare’s facilities are in good working order, including electrical, plumbing, HVAC, furnishings and waste management.
• Forecast, track, and manage project budgets, POs, and invoices.
• Develop effective partnerships and work collaboratively with internal business partners (HR, Finance, IT).
• Ensure compliance with safety procedures in the building.
• Establish strong relationships with key civic leaders (NEOMED, Government Officials, Code Officials, Fire Safety, etc.)

What You’ll Need

• 5-10 years of relevant, progressive work experience in Facilities or Operations.  Previous experience in a lab environment would be an asset.
• Demonstrated project management experience and excellent organizational skills to prioritize multiple work streams, deadlines, and priorities.
• Strong expertise and proven track record in process improvement.
• Strong customer orientation that enables Facilities to align business goals with customer needs and creatively problem solve to determine solutions.
• Excellent interpersonal, negotiation, influence, and communications skill with proven ability to communicate effectively across all departments and levels of the organization.
• Flexible and adaptable working style that enables work in a fast-paced working environment and work in a diplomatic and tactful manner with others.
• Bachelor’s degree in science or related field.
• Ability to read and understand blueprints, CAD drawings and other schematics.
• Bilingual; excellent verbal and written communication in French and English.
• Proficient in Microsoft Office Suite (Word, Excel, PowerPoint).

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Scientific Collaborations Manager

Company: Repare Therapeutics

Location:  Montreal, Quebec, CAN or Cambridge, MA, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

In the role of Manager, Scientific Collaborations you will be responsible for supporting external engagements with limited oversight.

Your main responsibilities will be to implement and manage the external scientific research projects spanning multiple academic institutions.  You will work with internal stakeholders, including senior leadership and scientific investigators from Business Development, Clinical Development, Cancer Biology Group and Translational Medicine.

What You’ll Do

• Provide scientific oversight and guidance of scientific research proposals
• Drive scientific collaborations to reach objectives and publications
• Interaction with external business functions from external research partners such as universities, research hospitals and companies to represent Repare as a partner of choice for research collaborations
• Implementation and management of research collaborations and license agreements
• Implementation and management of Confidentiality Agreements, Consulting Agreements

What You’ll Need

• Ph.D. in life sciences required
• Minimum of 7 years of related experience in life sciences industry preferred
• Strong transaction experience working in both an academic technology transfer and pharmaceutical/biotechnology settings is desirable (7+ years).
• Experience in contract negotiation for collaboration agreements, licenses, material transfer agreements, complex strategic alliance agreements for research enabling technologies/platforms in a matrix organization (BD&L, Legal, Patents, Finance and Corporate)
• Strong analytical and communication skills, and excellent skills in both prioritization and time management are required.
• Demonstrated understanding of the drug development process including direct experience working in the pharmaceutical or biotechnology industry
• Deep understanding of cancer biology, genomics, knowledge in DNA damage repair pathways and molecular pathology preferred
• The successful candidate will have a strong sense for urgency, be a team player, and bring a creative approach to problem solving.
• Reliability, self- awareness, and initiative are essential.
• The candidate must have a genuine passion for science, as well as personal determination for excellence and for finding new ways to perform his/her job better.
• The Manager, Scientific Collaborations must be able to multi-task and work in a matrixed environment to integrate feedback from stakeholders and manage the execution of all necessary agreements and research projects.
• Knowledge of intellectual property, licensing, and research contracts
• Ability to make independent judgments and act on decisions on a daily basis and assumes responsibility for decisions, outcomes, and results having an impact on people, costs, and/or quality within the functional area
• Ability to work flexibly on multiple tasks simultaneously and to meet various concurrent deadlines
• Experience with various software applications (e.g. spreadsheets, relational databases, statistical and graphic packages), to assemble, manipulate and/or format data and/or reports
• Ability to effectively interact with all levels of industry and academic collaborators, including principal investigators
• Ability to facilitate interactions designed to strengthen the relationship between academic collaborators and Repare
• Highly organized, resourceful, and detail oriented
• Excellent communication, presentation, and interpersonal skills

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Research Scientist, Target Discovery

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as RP-6306, a first-in-class inhibitor for CCNE1-amplified tumors, and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

The successful candidate will be an expert in at least one of the following research areas: DNA repair, epigenetics, cancer biology, cell/molecular biology, synthetic lethality, immuno-oncology, and/or genome engineering. The candidate will become a vital member of our SNIPRx® platform team where he/she will contribute both experimentally and intellectually to design and execute new SL campaigns and to generate a pool of validated drug targets to advance our portfolio. A critical component of the job will be the close collaboration with internal cancer biology, drug discovery, and computational biology teams.

What You’ll Do

• Become a crucial technical leader on our SNIPRx® target discovery platform
• Utilize CRISPR/Cas9 genome editing and other cell biology tools to generate and characterize cell line models for SL screens, target validation, and mechanism of action studies
• Design and execute CRISPR-enabled genome-wide screens
• Fully characterize cancer cell line panels: expanding, banking, and confirming loss-of-function or gain-of-function gene mutations by sequencing, qPCR, immunoblotting, and functional assays
• Apply skill set to identify and fully validate new SL targets
• Plan and execute experiments to uncover mechanisms underlying SL interactions
• Facilitate the development of computational biology tools by working closely with our bioinformatics team

What You’ll Need

• M.Sc. in Molecular Genetics, Cancer Biology, Cell and Molecular Biology, Immunology or related fields
• Minimum 1 year experience in tissue culture
• Expertise in cell and molecular biology techniques required (i.e. proliferation assays, microscopy, cytogenetics, PCR, immunoblotting, etc.)
• Theoretical or hands-on experience in genome editing techniques (CRISPR, TALENs, ZFNs, etc.) to generate gene knockout and knock-in cell lines
• Experience in functional genomics (especially RNAi or CRISPR screens) would be an asset
• Experience in lentiviral or retroviral packaging and cell line transductions would be an asset
• Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
• Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
• Ability to handle multiple projects and utilize judgement to prioritize tasks
• Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Junior DMPK Scientist

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as RP-6306, a first-in-class inhibitor for CCNE1-amplified tumors, and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

We now have an exciting opening at our Montreal site for a contract position in the Drug Metabolism and Pharmacokinetics group.   This position is an excellent opportunity to learn drug discovery with a leading precision oncology company.  The successful candidate will possess hands-on laboratory skills and will have the opportunity develop expertise with numerous in vitro assay techniques and mass spectrometry.  A critical component of the job will be the close collaboration with DMPK scientists as well as supporting various laboratory operations.

Note: This is a 6-month contract position, with the possibility of renewal up to 12 months

What You’ll Do

• Conduct established ADME/DMPK assays.
• Schedule and organize studies with various CROs.
• Maintain laboratory equipment including mass spectrometers, HPLC and pre-formulation tools.
• Manage inventories and order consumables as needed.

What You’ll Need

• in Chemistry, Biochemistry, Biology or related fields with some experience in ADME/DMPK in an industrial setting.
• Recent graduates (MSc, BSc) and co-op students in a related field with a keen interest to learn new techniques are encouraged to apply.
• Ability to communicate in an open, clear, timely and consistent manner.
• Outstanding organizational skills (planning, ordering, documentation in lab notebooks etc..).
• Ability to multitask and utilize judgement to prioritize tasks.
• Ability to contribute as a team member in a dynamic, fast-paced biotech environment.
• Experience in pre-clinical drug discovery, formulation or bioanalytical mass spectrometry is considered an asset.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Scientific Collaborations Manager

Company: Repare Therapeutics

Location: Montreal, Quebec, CAN or Cambridge, MA, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

In the role of Manager, Scientific Collaborations you will be responsible for supporting external engagements with limited oversight.

Your main responsibilities will be to implement and manage the external scientific research projects spanning multiple academic institutions.  You will work with internal stakeholders, including senior leadership and scientific investigators from Business Development, Clinical Development, Cancer Biology Group and Translational Medicine.

What You’ll Do

• Provide scientific oversight and guidance of scientific research proposals
• Drive scientific collaborations to reach objectives and publications
• Interaction with external business functions from external research partners such as universities, research hospitals and companies to represent Repare as a partner of choice for research collaborations
• Implementation and management of research collaborations and license agreements
• Implementation and management of Confidentiality Agreements, Consulting Agreements

What You’ll Need

• Ph.D. in life sciences required
• Minimum of 7 years of related experience in life sciences industry preferred
• Strong transaction experience working in both an academic technology transfer and pharmaceutical/biotechnology settings is desirable (7+ years).
• Experience in contract negotiation for collaboration agreements, licenses, material transfer agreements, complex strategic alliance agreements for research enabling technologies/platforms in a matrix organization (BD&L, Legal, Patents, Finance and Corporate)
• Strong analytical and communication skills, and excellent skills in both prioritization and time management are required.
• Demonstrated understanding of the drug development process including direct experience working in the pharmaceutical or biotechnology industry
• Deep understanding of cancer biology, genomics, knowledge in DNA damage repair pathways and molecular pathology preferred
• The successful candidate will have a strong sense for urgency, be a team player, and bring a creative approach to problem solving.
• Reliability, self- awareness, and initiative are essential.
• The candidate must have a genuine passion for science, as well as personal determination for excellence and for finding new ways to perform his/her job better.
• The Manager, Scientific Collaborations must be able to multi-task and work in a matrixed environment to integrate feedback from stakeholders and manage the execution of all necessary agreements and research projects.
• Knowledge of intellectual property, licensing, and research contracts
• Ability to make independent judgments and act on decisions on a daily basis and assumes responsibility for decisions, outcomes, and results having an impact on people, costs, and/or quality within the functional area
• Ability to work flexibly on multiple tasks simultaneously and to meet various concurrent deadlines
• Experience with various software applications (e.g. spreadsheets, relational databases, statistical and graphic packages), to assemble, manipulate and/or format data and/or reports
• Ability to effectively interact with all levels of industry and academic collaborators, including principal investigators
• Ability to facilitate interactions designed to strengthen the relationship between academic collaborators and Repare
• Highly organized, resourceful, and detail oriented
• Excellent communication, presentation, and interpersonal skills

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Senior Scientist, Analytical Development

Company: Repare Therapeutics

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

About Repare Therapeutics

We’re a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. So, if you’re ready to work on scientific breakthroughs where your desire to be part of a collaborative team of scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives, let’s talk.

About the Role

The Senior Scientist, Analytical Development will be the analytical lead to support both drug substance and drug product development across various clinical development stages. In addition to providing top-tier expertise in analytical development, the successful candidate will manage external contract labs, collaborating closely with chemical process, formulation, QA, and regulatory to assure adherence to phase-appropriate regulatory and quality requirements.

The position reports the head of the Analytical Development department.

What You’ll Do

• Works with external partners to develop analytical methods for drug substance and drug product, and oversees phase-appropriate validation, testing, and data receipt.
• Coordinates formal and informal stability studies, applies statistical methods of analysis and trending, and guides project team activities based on stability outcomes.
• Establishes phase-appropriate specifications and control strategies for materials, and authors justification of specification documents.
• Critically reviews and approves methods and protocols, authors development reports, and contributes to the preparation of the analytical sections of regulatory submissions.
• Troubleshoots analytical issues at external sites, conducts systematic process risk assessments, and collaborates with Quality to manage out-of-specification results.
• Effectively and professionally represents the Analytical Development function on cross functional project teams, collaborating to define phase-appropriate development strategies and meet overall program goals and timelines.

What You’ll Need

• Ph.D. with 3+ years working experience or MS degree with 8+ years working experience of relevant analytical experience in the pharmaceutical industry, including direct experience with solid oral dosage forms.
• Extensive practical experience in analytical techniques, including HPLC, GC. dissolution, and various impurity identification techniques.
• A well-grounded foundation in other characterization techniques including MS, NMR, UV, IR spectroscopy, and XRPD, DSC, PSD, TGA.
• Proven track record in leading analytical development activities for both drug substance and drug product across both early and late phases of clinical development.
• Strong oral and written communication skills, with experience in preparing protocols, technical reports, and regulatory filings.
• Good knowledge of regulatory (ICH, FDA, EMA) and compendial guidance and practical experience in meeting requirements in a phase-appropriate manner.
• Strong problem-solving skills and proven ability overcome analytical challenges while working within project timelines.
• Experience in developing aggressive but realistic timelines for functional activities and demonstrated success in delivering results according to integrated program plans.
• Ability to contribute leadership, independent judgement, and an enthusiastic attitude to our fast-paced and dynamic environment.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Manager/Senior Manager, Statistical Programming

Company: Repare Therapeutics

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

About Repare Therapeutics

We’re a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. So, if you’re ready to work on scientific breakthroughs where your desire to be part of a collaborative team of scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives, let’s talk.

About the Role

We are seeking an experienced SAS programmer who is a self-starter with advanced technical skills and managerial skills.

Reporting to the Head of statistical programming, the candidate will be responsible for the development, maintenance of statistical programming functions to support various projects.  The candidate will have a chance to involve developing an overall strategy for the programming group, updating the SAS programming Infrastructure, and coordinating the effort across studies to identify, develop and implement departmental standards, applications, processes, and training. The candidate provides timely support to the project teams on statistical programming matters according to the project strategies and is responsible for addressing administrative functions required for project management and milestones, identifying, and communicating changes in project requirements that may affect key deliverables at the project level.

What You’ll Do

• Develop SAS programs which generate datasets, complex listings, tables (including those with descriptive and standard inferential statistics in collaboration with a Statistician), and complex graphs.
• Develop SAS programs that support regulatory requests, ISS/ISE analyses, commercial requests, and biostatistical ad-hoc analysis.
• Manage the programming activities on one or multiple projects, done internally and/or externally by CROs.
• Review SDTM/ADAM specs and datasets and define reviewer’s guide for multiple studies.
• May have to create SAS utility macros; write and implement test plans to support SAS macro development.
• Perform quality review on SAS programs generated by other Statistical Programmers.
• Function as a positive role model for setting high expectations for quality, creativity, and project ownership.
• Works collaboratively with Biostatistics, Data Management, Clinical Operation, Global Drug Safety, Medical Writing, Regulatory and Project Management management/staff to meet project deliverables and timelines for statistical analysis and reporting.
• Provide technical input into documents produced by other functions (e.g. biostatisticians, data managers, medical writers)
• Work with Biometrics team and other function for the development and maintenance of the data review and reporting tools, and any other statistical applications as appropriate, working collaboratively as part of a team.
• Be attentive to detail and have the ability to independently resolve a variety of issues without close supervision.
• Understand and follow FDA regulations which affect the reporting of clinical trial data. This includes good clinical practice and guidelines for electronic submissions.
• Identify new tools to increase efficiency and quality as applied to clinical trials by reading relevant journals and/or attending courses/programming meetings.

What You’ll Need

• Sc/B.A. in Science, Statistics, Mathematics, Computer Science, Engineering or related field (MS preferred).
• Minimum of 5 years of clinical trial programming experience in the biotechnology, pharmaceutical or health related industry.
• Advanced SAS programming skills and experience in other statistical software, such as R and S-Plus.
• Experience and in-depth knowledge in CDISC including SDTM, ADaM, and controlled terminologies.
• Self-directed, technically strong, and a recognized leader maintaining a strategic prospective regarding statistical programming processes, management of statistical programming projects.
• Excellent organizational skills and ability to prioritize tasks.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Document Control

Company: Repare Therapeutics

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

About Repare Therapeutics

We’re a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. So, if you’re ready to work on scientific breakthroughs where your desire to be part of a collaborative team of scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives, let’s talk.

About the Role

Repare Therapeutics is looking for a Document Control Specialist whose primary responsibility is coordinating Document Control and activities related to the identification, collection, distribution and filing of controlled documents in an FDA regulated environment.  This position supports critical documentation within cross-functional teams and will ensure the integrity of document creation, version control, storage, retrieval, and lifecycle management are effectively implemented.  This position will aid in ensuring that document management is consistent across the organization, while maintaining control and traceability of the documentation history in compliance with GxP regulations.  Key contributions of the role will include maintaining document control procedures as well as participation in the development and deployment of document control tools.

What You’ll Do

• Independently manage and monitor the processing, review, and approval of all controlled documents in both electronic document management systems (DMS) and supporting manual systems
• Coordinate the revision process of Standard Operating Procedures (SOPs), forms, and other controlled documents assuring that the corporate and regulatory standards are upheld
• Manage the daily flow and final release of controlled documents through the document management system
• Continuous improvement of the Document Control program
• Provide user assistance and training on the DMS
• Deliver training regarding document control processes, QA orientation, and set up of new employees into the QMS
• Ensure compliance with controlled document format and content
• Maintain master documents and records (both hardcopy and/or electronic) to ensure documentation is retrievable and files are accurate, complete, and well organized
• Manage the document periodic review process
• Responsible for managing record retention policies and procedures
• Track and communicate company training compliance within multiple departments
• Assist with the development of evolving document control systems
• Maintain SOP, change control, deviations, CAPA follow-up, and logs contemporaneously
• Assist with generating Quality Document Control metrics, as needed
• Assist Quality Management by performing various tasks in support of the administration and maintenance of Quality Systems

What You’ll Need

• Bachelor’s degree
• Highly Proficient in Word, Excel, and PowerPoint
• Must be computer savvy with the capability to learn new systems
• Knowledge of Smartsheet and SharePoint are a plus
• Highly organized and ability to multitask in a fast-paced environment
• Worked in an FDA regulated environment is a plus
• Proficient in document management systems
• Strong interpersonal and communication skills
• Ability to organize and prioritize work
• Strong written and verbal communication skills
• Ability to review others documentation to spot any errors
• Any QA document control experience a plus

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Clinical Trial Manager/Senior Clinical Trial Manager

Company: Repare Therapeutics

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

About Repare Therapeutics

We’re a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. So, if you’re ready to work on scientific breakthroughs where your desire to be part of a collaborative team of scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives, let’s talk.

About the Role

We are seeking a Clinical Trial Manager/Senior Clinical Trial Manager with the passion and desire to become part of a fast-based, innovative team committed to developing breakthrough cancer therapies. The individual will be a self-starter that is effective in working independently as well as a collaborative team member. The successful candidate will ensure the Company’s clinical trial(s), in support of its innovative clinical pipeline, are managed to the highest quality to ensure safety and effectiveness of products in adherence with all applicable regulations.

What You’ll Do

• Lead cross-functional trial team to ensure delivery of complex clinical trials and manages protocol execution
• Oversee CROs and vendors to ensure timelines, goals and deliverables are met with quality, within budget, and in accordance with SOPs, GCP and all applicable laws and regulations.
• Provide input to the clinical development plan and operational aspects of the clinical trial protocol (e.g., develops and/or reviews operational plans for trials).
• Prepare/review site study documents (i.e., site-specific informed consent, study tools/worksheets, investigator contracts, and site payments).
• Identify and anticipate operational risks and mitigation plans within assigned clinical trials and escalates issues and recommends contingency plans to Head of Clinical Operations as necessary.
• Establish study milestones and ensure accurate tracking and reporting of study metrics, timelines, update of trial information in all trial databases and tracking systems.
• Provide monitoring oversight including authoring of oversight plan, reviewing monitoring visit reports and perform periodic oversight visits to sites and/or vendors to assess progress and compliance.
• Manage clinical trial budgets, providing ongoing financial reporting and projections to the finance group and facilitate the development of clinical trial agreements, insurance and other relevant documents in conjunction with legal.
• Ensure the Trial Master File (TMF) is maintained throughout the trial and performs inspection readiness checks throughout the lifecycle of the trial.
• Serve as functional area reviewer of global clinical / regulatory submissions.
• Present study status reports of operational execution activities to senior management.
• Provide study specific mentor and training for in-house Clinical Research Associate(s).
• Participate in operational process improvement initiatives (including, training, SOP review and development of work instructions/tools/templates).
• Perform other duties as assigned

What You’ll Need

• Bachelor’s degree in a life science or a health-related field is preferred, Advanced degree highly preferred
• Five (5) years or more of progressive clinical management experience with the biotech / pharmaceutical industry or in a clinical research organization (oncology experience highly preferred), global trial experience highly preferred
• Solid understanding of the clinical trial database life cycle including, data collection, review and analysis, CRF design, database development and testing, discrepancy management, data quality review and database close and lock procedures
• Strong understanding of FDA/ICH guidelines and industry standard practices regarding clinical trial management
• Excels in a fast-paced, high-growth company environment with minimal direction and a high-degree of independence and able to adjust workload based on changing priorities
• Collaborative team player who is also an independent thinker; ability to develop a strong point of view combined with the openness to evolving that view based on new data and analysis
• Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
• Ability to handle multiple projects and utilize judgement to prioritize tasks
• Ability to contribute as a team member in a dynamic, fast-paced biotech environment

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Principal Scientist – Clinical Bioinformatics

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes two clinical programs: RP-3500, a potential leading ATR inhibitor; and RP-6306, a first-in-class PKMYT1 inhibitor; as well as pre-clinical assets such as a Polθ inhibitor.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives. From its inception, Repare has based its development strategy on precision oncology.

We are seeking an Associate Director – Discovery Bioinformatics with the passion and desire to become part of a fast-paced, innovative team committed to developing breakthrough cancer therapies. The individual will be a self-starter that is effective in working independently as well as managing a small team of scientists. The successful candidate will help define and implement the company’s discovery bioinformatics strategy. They will collaborate with members of our SNIPRx® platform team to identify novel synthetic-lethal targets and expand patient populations. Furthermore, they will collaborate with translational scientists to help identify patient populations where our drugs are efficacious and effectively lead them into the clinic.

Responsibilities:

• Manage and develop a team of two bioinformatics scientists specialized in the analysis of CRISPR screens and providing support for discovery programs
• Be an internal thought leader on biomarker identification based on drug response experiments
• Design, implement and improve analytical approaches for target and biomarker identification based on cell line response to drug treatment
• Collaborate with and support target discovery and translational teams in the design of experiments and analysis of genomic datasets
• Lead the interactions with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based oncology biomarker discovery
• Develop and apply computational, statistical, and machine learning methods to mine multi-dimensional genome-scale data sets and derive biological insights
• Execute integrative analyses of cancer omics, clinical information and functional genomic data to support prioritization of targets and stratification of patients

Qualifications:

• PhD in Bioinformatics, Computational Biology, System Biology, or related fields
• Work experience
  • Four (4) years or more of bioinformatics research experience in the biotech or pharmaceutical industry, or
  • Six (6) years or more of post-doctoral academic bioinformatics experience in oncology target discovery, oncology translational sciences, or oncology clinical genomics
• Desired scientific experience
  • Cancer biology and cancer genomics. Experience with DNA Damage and Repair pathways is desirable.
  • Analysis of drug response data. Experience with multiplexed experiments (e.g. PRISM) and/or sophisticated approaches (e.g. GR50) is desirable.
  • Analysis of large cell line panel data such as CRISPR-Cas9 knockout screens
  • Familiarity with large genomic datasets such as the Cancer Dependency Map, The Cancer Genome Atlas, Genotype-Tissue Expression (GTEx).
• Experience working closely with biology teams to design and analyze experiments.
• Strong hands-on programing skills (R, Python, Unix, SQL, etc).
• Solid understanding of probability and statistics.
• Management experience highly desirable.
• Collaborative team player who is also an independent thinker; ability to develop a strong point of view combined with the openness to evolving that view based on new data and analysis.
• Ability to handle multiple projects and utilize judgement to prioritize tasks.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.