CAREERS

Position: Research Scientist – ADME/DMPK

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role 

We now have an outstanding opportunity available at our Montreal site for a motivated and accomplished ADME/DMPK scientist who would like to get in early and grow with the company. The successful candidate will have a thorough, hands-on background in drug metabolism and pharmacokinetics.  A demonstrated expertise performing complex and novel in vitro techniques is needed.  A critical component of the job will be the close collaboration with internal drug discovery teams and CROs.

      What You’ll Do

• Develop, validate and execute novel ADME/DMPK assays.
• Utilize in vitro and analytical tools to elucidate metabolic and elimination mechanisms for new chemical entities.
• Review large amounts of data to select appropriate compounds for assay screening.
• Plan and execute experiments to support progression of projects.
• Apply additional in vitro DMPK assays to drive compound progression.
• Contribute intellectually to drug development programs.

What You’ll Need

• in Chemistry, Biochemistry or related fields with several years of experience in ADME/DMPK in an industrial setting.  Recent PhD graduates in a related field with a keen interest to learn new techniques are encouraged to apply.
• Experience in one or more of the following fields: assay development, pharmacokinetics, in vitro DMPK assays, metabolite identification and/or bioanalytical mass spectrometry.
• Ability to communicate in an open, clear, timely and consistent manner.
• Outstanding organizational skills (study planning, experimental design, lab notebooks etc..).
• Ability to handle multiple projects and utilize judgement to prioritize tasks.
• Ability to contribute as a team member in a dynamic, fast-paced biotech environment.
• Experience in pre-clinical drug discovery is an asset.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, provincial, or local law.

Position: Operations Manager, Nonclinical Development

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

We are seeking an Operations Manager, Nonclinical Development with the passion and desire to become part of a fast-based, innovative team committed to developing breakthrough cancer therapies. This individual will coordinate with nonclinical development team members, translational researchers, and clinical operations team members in order to implement and maintain pharmacokinetic sample operational plans. This position requires a combination of scientific and project management expertise as they will be responsible for the oversight of nonclinical development outsourced activities supporting IND-enabling studies as well as within clinical trials; Includes operational support for CRO selection and contracting, bioanalytical method development, coordination and oversight of GLP and clinical bioanalysis.

What You’ll Do

• Manage end-to-end sample tracking and logistics for nonclinical and clinical samples, working closely with the central and bioanalytical lab vendors as well as a sample and data management vendor in collaboration with internal colleagues
• Identify, triage, and resolve sample queries to ensure sample and data integrity
• Monitor trends and quality metrics as they relate to clinical site sample collection, processing and shipment errors
• Ensure nonclinical assays and date meet appropriate FDA/EMA/GCP/ICH guidelines
• Collaborate with internal and CRO quality organizations to implement appropriate SOPs, audits readiness plans, and vendor qualifications
• Manage contracts and relationships with key CRO partners
• Collaborate with the other operations functions, clinical and biomarker operations, to insure seamless sample analysis and data delivery

What You’ll Need

• Bachelor’s degree with Science focus
• Experience managing bioanalytical labs study startup and oversight
• 3-5 years experience in biopharma with a focus on bioanalytical/pharmacokinetic laboratory management and/lor operations
• Strong verbal and written communication skills
• Excellent interpersonal and organizational skills
• Ability to deal with competing priorities
• Strong reasoning, detail orientation and problem-solving abilities are essential
• Ability to work on teams and on multiple concurrent projects, and works well under general direction with tight timelines

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

POSITION DESCRIPTION

Position: Scientist – In vitro/In vivo Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

The Pharmacology department is seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vitro/ in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be part of a drug development team and be responsible for the selection and characterization of oncology study models, evaluation of drug efficacy and tolerability, and the evaluation of dose scheduling and drug combinations strategies of Repare drug candidates with targeted agents / immuno-oncology therapeutics.  The position will involve the discovery of pharmacodynamic (PD) markers and establishment of assays to measure target-mediated signaling pathways and the development of pharmacokinetic/PD/efficacy relationships to help guide clinical study design.

What You’ll Do

• The level of position and responsibilities will be adjusted according to the candidate’s background and experience level.
• To implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
• To carry out animal experimentation including tumor cell inoculations, drug administrations (multiple routes), animal health monitoring, anesthesia, blood samplings (multiple routes), necropsies, and to monitor tumor progression through a variety of modalities including caliper measurements and luminescence imaging.
• To design, implement and carry out PD assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR or other means.
• To harvest tumor and tissue samples from treated animals to help establish PK/PD/efficacy and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
• To participate in ongoing in vivo new drug target validation work.
• To manage outsourced research studies to local and international CROs.
• To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
• To maintain detailed laboratory notes and protocols.
• The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

What You’ll Need

• PhD in biological sciences and minimum of 2 years relevant experience or an MSc with 5 years of relevant experience.
• Experience in oncology is essential, DNA repair and/or chromatin remodelling an asset.
• Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models.
• A strong background in cell biology, and quantitative cell-based growth and viability assay development using various modalities.
• Diverse experience in cell biology, DNA damage and repair, cell cycle assays and biochemical techniques is an asset
• Experience in pre-clinical drug discovery in an industrial setting is an asset.
• Ability to communicate in an open, clear, timely and consistent manner in project team meetings and internal company presentations.

• Outstanding organizational skills (lab book, experimental design, documentation etc.).
• Ability to handle multiple projects and utilize judgement to prioritize tasks.
• Ability to contribute as an initiator and a team member in a dynamic, fast-paced biotech environment.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Bioinformatics Data Engineer Manager/Senior Manager

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

From its inception, Repare has based its development strategy on precision oncology. This strategy is dependent on extensive and diverse high-dimensional biological data.

We are seeking a Bioinformatics Data Engineer who will create computational resources necessary for the organization and analysis of these data. This individual will work alongside a team of analysts on the development of novel tools and analytical approaches. Furthermore, they will collaborate with a diverse team of pre-clinical and clinical scientists to enable Repare’s continued success as a data-driven organization.

Responsibilities:

• Implement and deploy highly parallelized pipelines using cloud computing.
• Manage local and cloud computing resources; work closely with bioinformaticians to enable their analyses.
• Implement and maintain tools to visualize and access genomic data.
• Collaborate with internal stakeholders to devise appropriate solutions for managing internal/external data and making it easily accessible for downstream applications.
• Manage relationships with external software and data vendors.
• Act as an educator on practices for software engineering within team. For example, promote good coding practice, use of version control, testing, and documentation.

Qualifications:

• Relevant graduate degree or equivalent industry experience (5+ years preferred)
• Cloud computing experience. GCP is preferred.
• Experience analyzing biological or ‘omics’ data. Experience in oncology is preferred.
• Strong hands-on programing skills (e.g. R, Python, shell scripting, C++, Java, etc)
• Experience creating, managing, and querying databases (e.g. SQL, PostgresSQL) or other data warehousing solutions.
• Experience developing scientific data visualization solutions. Familiarity with tools such as R Shiny, Streamlit, Dash and TIBCO Spotfire is preferred.
• Demonstrated ability to translate data requirements between bench scientists and data/IT professionals.
• Collaborative team player who is also an independent thinker and innovator; ability to develop a strong point of view combined with the openness to evolving that view based on new data and analysis.
• Ability to handle multiple projects and utilize judgement to prioritize tasks.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Manager of SEC Reporting

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

We now have an outstanding opportunity available at our Montreal corporate office for a motivated and accomplished Manager of SEC Reporting to join our dynamic, growing finance team. The successful candidate will play a pivotal role in our finance team and will assist in the preparation of timely and accurate financial reporting.

What You Will Do

• Continuously review and monitor new accounting pronouncements and competitor’s filings to ensure our disclosures are in line with accounting standards and our peer group
• Manage the implementation of new accounting pronouncements, including analysis of new accounting pronouncements and effects on the Company, implementation requirements from a systems and information perspective, preparation of adoption journal entries and disclosures, as well as continued oversight and monitoring of proper implementation of new accounting pronouncements
• Analyze and document complex and/or non-recurring transactions by properly identifying accounting implications of various explicit terms and implied nuances, applying appropriate accounting rules and literature and exercising judgement in subjective areas to draw reasonable and acceptable conclusions
• Provide assistance to the VP Finance and Corporate Controller and the Finance Director on the external financial reporting process: ensuring that the annual report (10-K), quarterly reports (10-Q’s), and proxy statement are prepared in compliance with company policies and directives, U.S. GAAP, and applicable SEC reporting requirements, including XBRL
• Provide assistance to the VP Finance and Corporate Controller and the Finance Director on the preparation of the quarterly financial statements including the balance sheet and statements of operations, shareholders’ equity and cash flow, and accompanying notes in accordance with US GAAP, including commentary for the MD&A analysis
• Provide assistance to the VP Finance and Corporate Controller and the Finance Director on the quarterly and annual external audit processes
• Manage special projects as requested, especially those related to design and implementation of new accounting practices, processes and policies.
• Assist with the overall development, implementation, and management of internal controls and preparation of SOX 404 compliance, including recommendations for business process improvements.

What You’ll Need

• Bachelor’s degree in Business, Accounting or Finance (or equivalent).
• Certified Public Accountant (CPA)
• Minimum of 5 years of in-house accounting experience at a public company and/or public accounting experience
• Strong knowledge of U.S. GAAP and SEC regulations S-X and S-K
• Biotech/pharma or high-tech industry experience is preferred.
• Strong knowledge of US GAAP and Sarbanes-Oxley Section 404
• Robust internal controls understanding and documentation of relevant financial processes
• Excellent verbal and written communication skills
• Ability to collaborate effectively in a fast-paced, cross-functional environment.
• Experience with tight deadlines and responsibility for accuracy and timeliness are essential.
• Demonstrated ability to work cooperatively with others as well as independently.
• Proficiency in English, both written and verbal; French considered an asset.
• Knowledge of Great Plains and Coupa considered an asset.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, provincial, or local law.

POSITION DESCRIPTION

Position: Information Technology Support Specialist

Company: Repare Therapeutics Inc.

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

About the Role

We are seeking a seasoned, passionate tech support professional looking to join a team that shares your high standards. Your excellent interpersonal skills enable you to provide stellar customer service across a wide range of end users. You are a results driven individual and who thrives on the success of a job well done. You enjoy working in a collaborative environment where you can interface with other teams to effectively troubleshoot and resolve issues.

What You Will Do:

• Assist customers via online helpdesk system, telephone, and remote support tools to diagnose technical issues related to PC operating systems, applications, network, servers, and peripherals
• Setup, deploy, maintain, and manage user devices (computers, laptops, and mobile phones) as well as applications or services required for the proper operation of these devices.
• Maintain help-desk application to develop support activity database
• Monitor and manage capacity and performance data to ensure the optimal operation of company systems and devices
• Promote awareness of information security issues among Repare staff and ensure that they understand and adhere to systems security policies and procedures
• Review system backup logs and assist with the development, implementation, maintenance and improvement of the Repare Data Backup and Disaster Recovery practice
• Assist in the implementation and maintenance of IT back-end systems
• Participate in the development of IT documentation (processes and /or SOPs)

What You’ll Need

• DEC / BAC in Information Technology or equivalent
• System management experience for the following platforms: Microsoft Windows, Apple MacOS, Active Directory, IOS, and Android.
• Strong technical knowledge of Microsoft Office 365, SharePoint Online and Office products
• Working experience on support and manage Microsoft SharePoint platform
• Excellent troubleshooting skills related to desktop/laptop computer hardware and software, demonstrating the ability to quickly resolve complex issues or suggest alternative solutions
• Excellent communication skills and ability to work in a growing team environment
• Good knowledge of network security practice and network standards
• Requires occasional lifting of equipment or materials up to 30 lbs
• Demonstrated ability to handle multiple support tasks contemporaneously.
• Able to be on-call outside working hours on regular basis
• Able to work outside working hours if needed
• Excellent command of both written and spoken English and French
• Knowledge of MDM and virtual machine is a plus

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Clinical Biomarker Lead

Company: Repare Therapeutics

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

About Repare Therapeutics

We’re a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. So, if you’re ready to work on scientific breakthroughs where your desire to be part of a collaborative team of scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives, let’s talk.

About the Role

We are seeking a Clinical Biomarker Lead that will be accountable for delivery of robust, scientifically driven biomarkers in drug development programs for synthetic lethal drug targets in oncology. This position reports directly to the Head of the Clinical Biomarkers and Diagnostics function. This individual will have the opportunity to impact an industry-leading portfolio of Synthetic Lethal Drug Programs from inception of drug candidate and throughout clinical development.

What You’ll Do

• Innovate, develop, and implement cutting edge science and technological advances into biomarker and companion diagnostic (CDx) strategies to guide indication selection, patient enrichment, and combination strategies.
• Deliver translational analysis plans and ensure its seamless incorporation into clinical study design and alignment with clinical study objectives. Measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules.
• Be the Clinical Biomarker Lead for multiple phase clinical trials ranging phase I-II.
• Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.
• Define novel mechanisms of resistance targeted therapies by studying tumors at relapse
• Collaborate with clinical teams on biomarker-related elements of study trial design and conduct and incorporating biomarkers into clinical protocols, lab manuals and consent forms
• Deliver scientific expertise and technical guidance to enable timely biomarker sample collection.
• Execute sample testing plan and deliver high quality biomarker data packages to inform clinical development and regulatory strategy. Point contact for resolving study biomarker issues.
• Collaborate and engage in high-performance working relationships with clinical operations, clinical science, biology leads, bioinformatics, and regulatory functions.
• Establish and manage external collaborations with leading academic groups, diagnostic partners, and CROs.
• Be a member of the team that builds the scientific credibility of Repare through contributions to the scientific literature (publications/presentations).

What You’ll Need

• Extensive experience in the development of clinical biomarkers with a proven track record of success.
• Five to eight years in biotechnology, pharmaceutical industry, or clinical setting in the application of biomarkers in clinical trials preferably in oncology biomarker development.
• Ph.D. in a life scientific discipline
• Highly experienced in oncology translational research on molecularly targeted therapies, with proven track record of high-impact contributions to biomarker discovery and/or assay development.
• Skilled and experienced in conducting clinical trials, conducting biomarker analyses on various clinical sample types, and working as part of a clinical study team.
• Up-to-date knowledge and deep understanding of major molecular and genomic assay technologies and platforms.
• Experience with developing and validating fit for purpose clinical assays
• Must have a strong sense of urgency and excellent skills in prioritization, planning, and execution in a demanding and fast-paced environment.
• Excellent interpersonal and collaborative skills, and the ability to thrive in a matrix environment.
• Know how to manage and influence research collaborations, contract laboratories and budgets.
• Take the lead when needed and know when it’s best to be a great follower.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Position: Associate Director/Director, Clinical Scientist

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Clinical Scientist, Associate Director/Director, to play a pivotal role in supporting key oncology programs. This position will report to the Head of Clinical Sciences. The Clinical Scientist will be responsible for providing scientific support for all clinical development activities. If desired the Clinical Scientist may also share or gain experience in our diagnostics development. This role offers a unique opportunity to progress your career by working on novel therapies in the DNA repair field, novel clinical trial designs and innovative approaches to global oncology drug development.

RESPONSIBILITIES

• Contribute to the development of clinical strategies and trial execution
• Perform ongoing review and analysis of study safety and efficacy data
• Provide support as needed for scientific issues that may arise during study execution
• Collaborate with the Clinical Operations group to develop consistent language and criteria for the Informed Consent Form (ICF), protocol eligibility, protocol safety, Case Report Forms (CRFs), etc.
• Collaborate with the Regulatory group Drafting of clinical scientific documents such as IND, IND amendments, Investigator Brochures, Annual Reports, CSRs and other FDA submissions, including scientific advice, IND, EoP2, pre-NDA/BLA meetings, NDA/BLA and MAA documents
• Develop relationships with appropriate consultants
• Understand the asset’s biological mechanism, clinical strategy, scientific interpretation of disease and target-based literature
• Understand and support creation of competitor landscape, medical need, regulatory strategy
• Perform literature searches and summarize the relevant scientific, drug development and medical literature to support document development, such as the investigator brochure, protocol design, clinical study report, competitive assessments, etc.
• Provide scientific/medical supportive materials to in-house staff and external consultants in the indications being studied
• Write abstracts and present data at scientific meetings, both internally and externally.
• Contribute positively to a strong culture of business integrity and ethics
• Act within compliance and legal requirements as well as within company guidelines

BASIC QUALIFICATIONS

• Bachelor’s degree in life sciences or related discipline (at minimum)

PREFERRED QUALIFICATIONS

• Advanced degree (e.g. MS, PhD, PharmD)
• Minimum of 3 years of experience in a pharmaceutical industry or CRO environment in drug development
• Prior Oncology Drug Development experience is required.
• Experience in developing and writing study protocols, study procedures manuals, informed consent forms and clinical study reports.
• Proven track record of working with investigators, site staff, external experts, Contract Research Organizations and vendors
• Demonstrated ability to work in matrix teams and in a fast-paced environment.
• Excellent management, communication and organizational skills required with demonstrated success in leading projects and interacting with cross functional teams
• Strong Analytical ability.
• Excellent interpersonal and decision-making skills.
• Ability to work independently and enthusiasm to deliver the program objectives in a timely manner. Negotiation and influential skills are advantageous.
• Demonstrated ability to comprehend complex scientific concepts and data. Proficient in reviewing and assessing clinical data.

Position: Coordinator, Clinical Biomarker Operations (CBO)

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Coordinator, CBO with the passion and desire to become part of a fast-based, innovative team committed to developing breakthrough cancer therapies. This individual will coordinate with translational researchers, clinical operations and PK team members in order to implement and maintain biomarker and clinical sample operational plans. This position requires a combination of scientific and project management expertise as they will be responsible for the support of clinical laboratory functions within clinical trials; Includes operational support for biomarker definition and selection, clinical testing schedules, and lab manual creation.

Responsibilities:

• Manage end-to-end sample tracking and logistics for clinical samples, working closely with the central and specialty lab vendors as well as a sample and data management vendor
• Identify, triage, and resolve biomarker sample queries to ensure sample and data integrity
• Monitor trends and quality metrics as they relate to clinical site sample collection, processing and shipment errors
• Ensure biomarker laboratory documents are filed appropriately in the eTMF
• Maintain biomarker documentation (requisition forms, analysis request forms, redacted patient files, etc.) in an organized manner
• Assist with creating site and team training tools as they relate to clinical biomarker operations
• Liaise with the preclinical teams to help drive translational research projects and ensure timely data delivery

Qualifications:

• Bachelor’s degree with Science focus
• Experience managing clinical labs study startup and oversight
• 1-3 years experience in clinical operations with a focus on clinical laboratory management
• Strong verbal and written communication skills
• Excellent interpersonal and organizational skills
• Ability to deal with competing priorities
• Strong reasoning, detail orientation and problem-solving abilities are essential
• Ability to work on teams and on multiple concurrent projects, and works well under general direction with tight timelines