Join us

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

The work place culture we have created is one of inclusion and engagement, where working hard and having fun go hand in hand. We believe our continued growth and future success is completely dependent on the creativity and diversity of our team members.

If you are interested in joining the Repare Therapeutics team, please fill out the form below and submit your CV.

Montréal, Québec, Canada

Accounts Payable Clerk

Position: Accounts Payable Clerk

Company: Repare Therapeutics

Location:  Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes two clinical programs: RP-3500, a potential leading ATR inhibitor; and RP-6306, a first-in-class PKMYT1 inhibitor; as well as pre-clinical assets such as a Polθ inhibitor.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives. From its inception, Repare has based its development strategy on precision oncology.

Position Overview:

We have an outstanding opportunity available at our Montreal corporate office for a motivated Accounts Payable Clerk to join our dynamic, growing finance team. The successful candidate will play a pivotal role in our finance team which oversees the day-to-day accounting of the divisions in Canada and the United States.

Responsibilities:

  • Maintain the accounts payable inbox; review, sort and file invoices.
  • Review, code and process invoices in Coupa for approval or for 3-way match with purchase orders and receipts.
  • Assist in researching and resolving all invoice discrepancies with other departments or suppliers.
  • Assist in the preparation and processing of payments in a timely manner with required documentation for approval.
  • Respond to supplier communications in a timely manner.
  • Maintain vendor records.
  • Maintain proper documentation of invoice cut-off issues at quarter-end.
  • Assist with any accounts payable related requests made by our external auditors.
  • Ensure all activities follow our internal controls and procedures.
  • Assist in ad hoc projects as needed.

Requirements:

  • 2-3 years’ experience with accounts payable or general accounting.
  • Knowledge of basic accounting principles.
  • High degree of attention to detail.
  • Ability to work under pressure and with deadlines.
  • Ability to work independently and prioritize tasks.
  • Ability to cooperate with others in a professional manner.
  • Ability to communicate in French and English.
  • Knowledge of Great Plains and Coupa considered an asset.
  • Biotech/pharma or high-tech industry experience is preferred.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Scientist – Cancer Biology

POSITION DESCRIPTION

Position: Scientist – Cancer Biology

Company: Repare Therapeutics

Location: Montreal, QC, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

 

About the Role

We are seeking a highly motivated cell biologist to complement the Cancer Biology team at our Montreal site. The scientist will be responsible, through designing and performing cell biology experiments and forward genetic screens, for investigating the mechanism-of-action of Repare drug candidates, identifying genetic/epigenetic mechanisms of drug sensitivity or resistance, and validating rational combinations of Repare drug candidates with other agents. As such, the scientist will contribute to a multi-disciplinary effort in pre-clinical discovery and development of novel anti-cancer agents, as well as inform the design of clinical trials.

 

What You’ll Do 

  • Develop cell-based assays to probe the mechanism-of-action of chemical compounds (e.g. immunofluorescence, immunoblotting, flow cytometry etc.)
  • Perform cell growth and viability assays to evaluate novel patient selection hypotheses
  • Design and develop cellular models of genetic alterations found in tumors using CRISPR/Cas9 and other genetic techniques
  • Perform and analyze CRISPR/Cas9 forward genetic screens
  • Efficiently communicate data at internal team meetings, participate in preparation of external presentations and peer-reviewed scientific publications
  • Coordinate experimental plans with other members of a multidisciplinary team
  • Maintain rigorous laboratory notes and data organization
  • Keep up with relevant scientific literature
  • The individual responsibilities may change from time to time based on requirements of a particular project
  • The level of position and responsibilities will be adjusted according to your background and experience

 

What You’ll Need

  • A MSc or PhD (or equivalent) in molecular biology or a related field
  • Experience with mammalian cell culture and standard cell biology techniques is essential (at least three of the following: basic cell culture, transfection and/or transduction, immunoblotting, immunofluorescence, viability assays, flow cytometry, CRISPR/Cas9 gene editing)
  • Previous research experience in the one of the following fields is highly valued: DNA damage repair, chromosomal instability, synthetic lethality, cell cycle, telomere biology
  • Pre-clinical drug discovery experience is an asset
  • Excellent oral and written scientific communication, organizational skills
  • Ability to handle multiple projects and utilize judgement to prioritize tasks

 

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Computational Chemist

POSITION DESCRIPTION

Position Computational Chemist

Company Repare Therapeutics

Location Montreal, Quebec, Canada

Website http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as RP-6306, a first-in-class inhibitor for CCNE1-amplified tumors, and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

 

About the Role

Repare Therapeutics is seeking an experienced computational chemist or medicinal chemist with extensive structure-based drug design experience to support internal drug discovery programs. The position requires scientific leadership and strong communication skills to collaborate with internal scientists and external service providers. The selected applicant must combine structure-based drug discovery and design experience, the desire to help others, resilience, and the ability to work effectively in a multidisciplinary environment. A person with a hybrid skillset and background (e.g., molecular modeling and medicinal chemistry, docking and machine learning, or docking and quantum mechanics) is preferred.  Candidates must have the ability to collaborate effectively, advance team goals, and enjoy a fast-paced, research environment.

What You’ll Do

  • Apply structure-based and ligand-based methods to design small molecule inhibitors of target proteins with desired drug-like properties that meet a specified target profile.
  • Help chemists prioritize proposed analogs in a timely, efficient, and independent manner.
  • Facilitate an iterative cycle of inspiring the chemists and being inspired by their ideas, to create a positive feedback loop to advance the optimization of analogs.
  • Participate in the development of scientific goals for specific programs.
  • Interact with medicinal chemists, biologists, and DMPK colleagues to inform program strategies.

What You’ll Need

  • Ph.D. degree with a minimum of 2 years relevant experience or M.Sc. degree with a minimum of 5 years of relevant experience in the field of drug discovery
  • Effective communication skills, both verbal and written.
  • Ability to work effectively as part of a multidisciplinary team.
  • Experience with molecular modeling software (MOE, Schrödinger, Discovery Studio / Pipeline Pilot, Cresset, Optibrium, OpenEye, and/or Sybyl).
  • Experience with performing docking studies is required, along with an understanding of the reliability and limitations of various computational results.
  • A working knowledge of organic chemistry.
  • Experience with hit discovery, hit-to-lead development, or lead optimization is an asset.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Scientist – In vitro/In vivo Biology

POSITION DESCRIPTION

Position: Scientist – In vitro/In vivo Biology

Company: Repare Therapeutics

Location: Montreal, Quebec, Canada

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

 

About the Role

The Pharmacology department is seeking an experienced scientist at our Montreal site to assume a hands-on role as part of a scientific team responsible for assessing the in vitro/ in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be part of a drug development team and be responsible for the selection and characterization of oncology study models, evaluation of drug efficacy and tolerability, and the evaluation of dose scheduling and drug combinations strategies of Repare drug candidates with targeted agents / immuno-oncology therapeutics.  The position will involve the discovery of pharmacodynamic (PD) markers and establishment of assays to measure target-mediated signaling pathways and the development of pharmacokinetic/PD/efficacy relationships to help guide clinical study design.

 

What You’ll Do

  • The level of position and responsibilities will be adjusted according to the candidate’s background and experience level.
  • To implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds.
  • To carry out animal experimentation including tumor cell inoculations, drug administrations (multiple routes), animal health monitoring, anesthesia, blood samplings (multiple routes), necropsies, and to monitor tumor progression through a variety of modalities including caliper measurements and luminescence imaging.
  • To design, implement and carry out PD assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR or other means.
  • To harvest tumor and tissue samples from treated animals to help establish PK/PD/efficacy and toxicity relationships in vivo for Repare’s pre-clinical drug candidates and drug combinations. To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities.
  • To participate in ongoing in vivo new drug target validation work.
  • To manage outsourced research studies to local and international CROs.
  • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals.
  • To maintain detailed laboratory notes and protocols.
  • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

What You’ll Need

  • PhD in biological sciences and minimum of 2 years relevant experience or an MSc with 5 years of relevant experience.
  • Experience in oncology is essential, DNA repair and/or chromatin remodelling an asset.
  • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models.
  • A strong background in cell biology, and quantitative cell-based growth and viability assay development using various modalities.
  • Diverse experience in cell biology, DNA damage and repair, cell cycle assays and biochemical techniques is an asset
  • Experience in pre-clinical drug discovery in an industrial setting is an asset.
  • Ability to communicate in an open, clear, timely and consistent manner in project team meetings and internal company presentations.
  • Outstanding organizational skills (lab book, experimental design, documentation etc.).
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.
  • Ability to contribute as an initiator and a team member in a dynamic, fast-paced biotech environment.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Cambridge, Massachusetts, USA

Senior Executive Assistant

Position: Senior Executive Assistant

Company: Repare Therapeutics

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

 

About Repare Therapeutics

We’re a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. So, if you’re ready to work on scientific breakthroughs where your desire to be part of a collaborative team of scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives, let’s talk.

 

About the Role

The Senior Executive Assistant will be a dynamic individual excited to join a growing international administrative team. The position will be responsible for managing complex calendars, travel schedules, and projects for three (3) Cambridge based executives. The ideal candidate will be a self-starter, a team player, organized and have strong attention to detail, and have excellent multi-tasking skills.

 

What You’ll Do

  • Manage complex and demanding calendars proactively and ability to resolve conflicts, coordinating with rest of the admin team as well as external partners where needed
  • Make travel arrangements, obtains appropriate travel documentation and process expense reports on a timely basis
  • Coordinate and attend team leadership meetings as needed; proactively manages agendas and necessary materials, coordinates logistics, take minutes and captures action items
  • Coordinate team functions or events, including room bookings, meals, etc.
  • Partner with HR function in support of recruiting and employee experience
  • Develop and maintain professional working relationships with internal and external parties
  • Prepare data for presentations as needed
  • Ensure the confidentiality of all reports, correspondence, materials, etc.
  • Perform other duties as assigned and seeks out opportunities to support assigned executives’ team as bandwidth allows
  • Engage and partner with the broader administrative team to identify best practices and opportunities for improvement

 

What You’ll Need

  • Minimum of Associate degree and 5 years of experience as AA/EA for executives
  • Strong sense of accountability and ownership to job responsibilities
  • Demonstrated ability to be flexible, take initiative, anticipate needs, and respond appropriately
  • Advance experience with Microsoft Office Suite (Outlook, Word, Excel, Visio, Teams and PowerPoint)

 

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Clinical Biomarker Lead

Position: Clinical Biomarker Lead

Company: Repare Therapeutics

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

 

About Repare Therapeutics

We’re a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. So, if you’re ready to work on scientific breakthroughs where your desire to be part of a collaborative team of scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives, let’s talk.

 

About the Role

We are seeking a Clinical Biomarker Lead that will be accountable for delivery of robust, scientifically driven biomarkers in drug development programs for synthetic lethal drug targets in oncology. This position reports directly to the Head of the Clinical Biomarkers and Diagnostics function. This individual will have the opportunity to impact an industry-leading portfolio of Synthetic Lethal Drug Programs from inception of drug candidate and throughout clinical development.

What You’ll Do

  • Innovate, develop, and implement cutting edge science and technological advances into biomarker and companion diagnostic (CDx) strategies to guide indication selection, patient enrichment, and combination strategies.
  • Deliver translational analysis plans and ensure its seamless incorporation into clinical study design and alignment with clinical study objectives. Measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules.
  • Be the Clinical Biomarker Lead for multiple phase clinical trials ranging phase I-II.
  • Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.
  • Define novel mechanisms of resistance targeted therapies by studying tumors at relapse
  • Collaborate with clinical teams on biomarker-related elements of study trial design and conduct and incorporating biomarkers into clinical protocols, lab manuals and consent forms
  • Deliver scientific expertise and technical guidance to enable timely biomarker sample collection.
  • Execute sample testing plan and deliver high quality biomarker data packages to inform clinical development and regulatory strategy. Point contact for resolving study biomarker issues.
  • Collaborate and engage in high-performance working relationships with clinical operations, clinical science, biology leads, bioinformatics, and regulatory functions.
  • Establish and manage external collaborations with leading academic groups, diagnostic partners, and CROs.
  • Be a member of the team that builds the scientific credibility of Repare through contributions to the scientific literature (publications/presentations).

What You’ll Need

  • Extensive experience in the development of clinical biomarkers with a proven track record of success.
  • Five to eight years in biotechnology, pharmaceutical industry, or clinical setting in the application of biomarkers in clinical trials preferably in oncology biomarker development.
  • Ph.D. in a life scientific discipline
  • Highly experienced in oncology translational research on molecularly targeted therapies, with proven track record of high-impact contributions to biomarker discovery and/or assay development.
  • Skilled and experienced in conducting clinical trials, conducting biomarker analyses on various clinical sample types, and working as part of a clinical study team.
  • Up-to-date knowledge and deep understanding of major molecular and genomic assay technologies and platforms.
  • Experience with developing and validating fit for purpose clinical assays.
  • Must have a strong sense of urgency and excellent skills in prioritization, planning, and execution in a demanding and fast-paced environment.
  • Excellent interpersonal and collaborative skills, and the ability to thrive in a matrix environment.
  • Know how to manage and influence research collaborations, contract laboratories and budgets.
  • Take the lead when needed and know when it’s best to be a great follower.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Principal Scientist - Clinical Bioinformatics

Position: Principal Scientist – Clinical Bioinformatics

Company: Repare Therapeutics

Location:  Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover highly targeted cancer therapies. Novel patient populations for compounds under development are identified in a data-driven process called STEP2. The Company’s pipeline includes two clinical programs: RP-3500, a potential leading ATR inhibitor; and RP-6306, a first-in-class PKMYT1 inhibitor; as well as pre-clinical assets such as a Polθ inhibitor.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives. From its inception, Repare has based its development strategy on precision oncology.

We are seeking a Principal Scientist – Clinical Bioinformatics who will extend this approach to the clinic. This individual will use genomic and clinical biomarker data to contextualize patient responses. They will develop and/or apply computational methods to analyze whole genome and panel-based sequencing of patient samples to uncover genomic signatures. Furthermore, they will collaborate with a diverse team of translational and clinical scientists to analyze and interpret data generated from Repare’s RP-6306 program.

 

Responsibilities:

  • Develop innovative approaches to integrate and visualize multi-dimensional biomarker data such as IHC, ctDNA, genomics, clinical response, clinical parameters, etc
  • Support patient selection and clinical trial enrollment based on genomic evidence
  • Lead the development and/or application of computational approaches to analyze custom and off-the shelf DNA-sequencing based molecular diagnostics (including WGS and panel-based sequencing) used for prospective and retrospective analysis of patient samples and to uncover genomic signatures
  • Analyze molecular data derived from clinical samples to discover biomarkers of response/resistance to therapy
  • Collaborate with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based clinical development
  • In collaboration with operations team, manage transfer and availability of clinical biomarker data
  • Utilize public and proprietary clinico-genomic databases to better understand patient populations
  • Propose testable hypothesis and communicate scientific findings to a diverse clinical development team to support program decisions

Minimum Qualifications:

  • PhD in Bioinformatics, Computational Biology, Cancer Genomics, Cancer Biology, or related fields
  • Preferred experience:
    • Two (2) years or more of bioinformatics research experience in the biotech, pharmaceutical or diagnostics, with a focus on oncology translational science, clinical genomics or genomic diagnostics; or equivalent post-doctoral experience
  • Desired scientific experience
    • Precision oncology drug development
    • DNA damage and DNA repair biology
    • Clinical genomics or diagnostics; especially whole genome sequencing
    • Variant interpretation
  • Passion for analyzing multi-dimensional translational data from clinical trials
  • Experience working closely with diverse biology, translational and clinical teams to design and analyze experiments.
  • Strong hands-on programing skills (e.g. R, Python, Unix, SQL, etc)
  • Solid understanding of probability and statistics.
  • Collaborative team player who is also an independent thinker; ability to develop a strong point of view combined with the openness to evolving that view based on new data and analysis
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Proficiency in communicating ideas and presenting complicated analyses to diverse audiences is required

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Contract Associate - Business Development

Position: Contract Associate

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes two clinical programs: RP-3500, a potential leading ATR inhibitor; and RP-6306, a first-in-class PKMYT1 inhibitor; as well as pre-clinical assets such as a Polθ inhibitor.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives. From its inception, Repare has based its development strategy on precision oncology.

Position Overview:

The Contract Associate will work as part of the Business Development team to ensure contract terms meet company compliance requirements and business goals and standards through effective drafting, negotiation and coordination. They must efficiently manage a large volume and variety of contracts, coordinating numerous agreements simultaneously while identifying issues and escalating where appropriate.

Responsibilities:

  • Review contracts to ensure accuracy of preparation, necessary clauses, compliance with company standards, and all applicable laws are addressed
  • Triage contract interpretation questions and escalate as appropriate
  • Recognize and flag potential risks with specific contract terms
  • Attend meetings on contract matters to resolve questions and find resolution
  • Coordinate and manage the entire contract workflow
  • Maintain contract and customer databases and files
  • Ensure appropriate contract review/approval processes are followed, and support escalation of contract issues and claims
  • Collaborate across teams to ensure that contractual commitments are well communicated, understood, and tracked
  • Offer recommendations for updates to standard templates and assist in drafting new templates as needed
  • All other duties as assigned

Requirements:

  • Bachelor’s degree in Business Administration or related discipline is required; Professional certification or advanced degree is a plus
  • 3 to 5 years of experience in biotech or pharmaceuticals
  • Must be able to demonstrate a knowledge of contract requirements including terms and conditions, special provisions and analysis of contract performance
  • Must be able to demonstrate time management, priority management, planning and coordination/multi-tasking skills
  • Works with a high attention to detail
  • Excellent oral and written communications skills
  • Strong computer skills, including knowledge of databases and spreadsheets, is required
  • Strong interpersonal and customer service skills

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Associate Director - Discovery Bioinformatics

Position: Principal Scientist – Clinical Bioinformatics

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes two clinical programs: RP-3500, a potential leading ATR inhibitor; and RP-6306, a first-in-class PKMYT1 inhibitor; as well as pre-clinical assets such as a Polθ inhibitor.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives. From its inception, Repare has based its development strategy on precision oncology.

We are seeking an Associate Director – Discovery Bioinformatics with the passion and desire to become part of a fast-paced, innovative team committed to developing breakthrough cancer therapies. The individual will be a self-starter that is effective in working independently as well as managing a small team of scientists. The successful candidate will help define and implement the company’s discovery bioinformatics strategy. They will collaborate with members of our SNIPRx® platform team to identify novel synthetic-lethal targets and expand patient populations. Furthermore, they will collaborate with translational scientists to help identify patient populations where our drugs are efficacious and effectively lead them into the clinic.

Responsibilities:

  • Manage and develop a team of two bioinformatics scientists specialized in the analysis of CRISPR screens and providing support for discovery programs
  • Be an internal thought leader on biomarker identification based on drug response experiments
  • Design, implement and improve analytical approaches for target and biomarker identification based on cell line response to drug treatment
  • Collaborate with and support target discovery and translational teams in the design of experiments and analysis of genomic datasets
  • Lead the interactions with internal and external teams to develop and implement a state-of-the-art computational analysis platform for omics-based oncology biomarker discovery
  • Develop and apply computational, statistical, and machine learning methods to mine multi-dimensional genome-scale data sets and derive biological insights
  • Execute integrative analyses of cancer omics, clinical information and functional genomic data to support prioritization of targets and stratification of patients

Qualifications:

  • PhD in Bioinformatics, Computational Biology, System Biology, or related fields
  • Work experience
    • Four (4) years or more of bioinformatics research experience in the biotech or pharmaceutical industry, or
    • Six (6) years or more of post-doctoral academic bioinformatics experience in oncology target discovery, oncology translational sciences, or oncology clinical genomics
  • Desired scientific experience
    • Cancer biology and cancer genomics. Experience with DNA Damage and Repair pathways is desirable.
    • Analysis of drug response data. Experience with multiplexed experiments (e.g. PRISM) and/or sophisticated approaches (e.g. GR50) is desirable.
    • Analysis of large cell line panel data such as CRISPR-Cas9 knockout screens
    • Familiarity with large genomic datasets such as the Cancer Dependency Map, The Cancer Genome Atlas, Genotype-Tissue Expression (GTEx).
  • Experience working closely with biology teams to design and analyze experiments.
  • Strong hands-on programing skills (R, Python, Unix, SQL, etc).
  • Solid understanding of probability and statistics.
  • Management experience highly desirable.
  • Collaborative team player who is also an independent thinker; ability to develop a strong point of view combined with the openness to evolving that view based on new data and analysis.
  • Ability to handle multiple projects and utilize judgement to prioritize tasks.

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Senior Clinical Trial Associate

POSITION DESCRIPTION

Position: Senior Clinical Trial Associate

Company: Repare Therapeutics

Location: Cambridge, MA, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

 

About the Role

We are seeking a clinical operations professional to join our growing Clinical Operations organization. This role will be key in supporting the execution and oversight of clinical trials. This is a great opportunity to join Repare as a key member of the clinical operations teams, supporting multiple clinical research studies. This individual will partner across the team and facilitate operational efficiencies in clinical trials, guided by SOPs and ICH-GCP.

What You’ll Do 

  • Works closely with Clinical Trial Manager (CTM), study teams, and Clinical Research Organizations (CRO) to support clinical study activities on one or more trials
  • Provides support for critical day-to-day clinical study activities, including regulatory inspection readiness, in accordance with established protocols
  • Participates in the preparation and maintenance of study manuals, site tools, templates, source documents, guidelines, newsletters, etc.
  • Responsible for set-up, filing, maintenance, reconciliations and archiving of the electronic Trial Master File (TMF) by collecting and QCing essential documents from clinical sites and vendors, uploading documents to the TMF and managing the TMF vendor for assigned clinical projects according to ICH-GCP
  • Assists with maintaining study status updates (examples include IRB approvals, regulatory document collection, patient enrollment, monitoring status, etc.)
  • Interacts with CROs, vendors, and other external partners to provide information and resolution for specific requests and issues
  • Assists CTM with agendas and meetings minutes for clinical operations meetings
  • Responsible for the oversights of study team roster maintenance and vendor contact lists
  • Assists CTM with logistics coordination for investigator meetings and external vendor meetings
  • Supports ad-hoc activities as needed, as agreed with CTM

What You’ll Need

  • Bachelor’s degree (scientific or healthcare discipline preferred) plus at least 2-5 years in clinical operations or drug development
  • Proven experience in the oversight of the operational aspects of clinical studies
  • Experience managing complex oncology trials
  • Familiarity and experience with clinical trial eTMF requirements and practices
  • Knowledge of ICH GCP
  • Excellent organizational as well as problem-solving skills as well as the ability to work independently
  • Ability to work in a fast pace, cross-functional, start-up environment

 

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Sr. Manager / Associate Director - GCP Quality Assurance

Position: GCP Quality Assurance Sr. Manager / Associate Director

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

 

About the Role

Repare Therapeutics is looking for a GCP Quality Assurance Sr. Manager or Associate Director whose primary responsibility is ensuring that Repare is in compliance with GCP regulations for multiple programs.  The GCP Manager will be a key member of Repare’s quality team that will assist in development of a phase-appropriate GCP quality system for early phase clinical trials.  This candidate will then evaluate and further develop the CQA function to ensure Inspection Readiness as it relates to pivotal clinical trials and commercialization.  This position supports US and ROW clinical trials.  This position reports to the Senior Director, Head of Quality.

 

What You’ll Do

  • Development of SOPs to support GCP compliance with consideration for the end users
  • Support the execution of Repare’s clinical development programs through administration and enforcement of the Quality Management System, providing GCP oversight including but not limited to deviations, corrective and preventative actions, investigations, and change controls, as applicable
  • Provide expertise in GCP compliance interpretation, consultation, training, and recommendations to assigned program teams
  • Complete routine TMF audits and work with the Repare clinical team and investigators, where necessary, to resolve any findings
  • Complete audits of GCP vendors
  • Complete clinical site audits
  • Develop and implement risk based GCP audit and compliance strategies and manage audits of sites, documents, databases, vendors or internal systems in compliance with GCP and Repare’s policies and procedures
  • Analyze, report, and present metrics for assigned programs to development teams and Repare QA management; recommend any required actions and monitor implementation
  • Assess impact of audit findings and other identified compliance risks to subject safety, data integrity, and business operations and escalate compliance risks to Repare QA management. Ensure audit reports and corrective actions are developed and completed within timelines mandated in internal procedures
  • Assist with investigations into significant quality issues, scientific misconduct and serious breach of GCP; facilitate identification of root cause and development of appropriate corrective and preventive actions; track actions and confirm effectiveness; ensure reporting of potential or confirmed violations to regulatory authorities
  • Provide GCP compliance support during inspections of investigator sites and Repare and assist with the development of appropriate and timely inspection responses and follow-up actions
  • Provide input and support for the development and improvement of QA processes
  • Establish and maintain effective working relationships with key internal and external stakeholders withing cross-functional teams

What You’ll Need

  • Bachelor’s Degree with 8 years of experience in a pharmaceutical or biotechnology industry role with at least 5 years of applicable GCP quality experience
  • Experience working in Clinical Operations; a huge plus
  • In depth technical knowledge of organizational management, cGMP quality systems, US and non-US cGMP regulations and FDA, EU and ICH guidelines with practical implications and applications for an early phase clinical setting
  • Excellent understanding of source documentation and TMF documentation
  • Experience in the implementation of GCP oversight to clinical development programs, including the review of compliance data, trending, risk assessment and development of mitigation strategies
  • Excellent understanding of the clinical trial process workflow from conception to study close-out
  • Must have experience conducting GCP Vendor Audits and Investigator Site Audits
  • Must have led GCP audits as a Lead Auditor
  • Prepare and/or organized GCP training
  • Interface with CROs to ensure timely communication between Repare QA and Clinical Development
  • Working knowledge of ICH GCP E6 (R2) and applicable global regulations and guidance for clinical development
  • A strong understanding of data management systems
  • Working knowledge of conduct and reporting of audits and the translation of findings into corrective actions plans that mitigate risks to the company, to safety and data integrity
  • Ability to think strategically and to proactively identify issues in various aspects of the drug development process
  • Ability to work effectively on multiple projects simultaneously with minimum supervision
  • Strong interpersonal and communication skills
  • Effective/concise communicator with management and internal teams

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

 

Director, Drug Product Development & Manufacturing

Position: Director, Drug Product Development & Manufacturing

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

 

About the Role

 

The Associate Director or Director, Drug Product Development & Manufacturing will lead formulation development and manufacturing of clinical and commercial drug product for all Repare programs. In addition to providing top-tier expertise in formulation development, the successful candidate will manage operations at external manufacturing sites, helping our oncology platform to bring innovative new therapies to patients. Other leadership responsibilities include assuring adherence to phase-appropriate regulatory and quality requirements, and representation of the drug product function on cross-functional teams.

The position reports the Senior Director, Pharmaceutical Sciences.

 

What You’ll Do

  • Leads the development and manufacturing of phase-appropriate dosage forms to supply clinical study drug and commercial supplies.
  • Contributes top-tier expertise to develop immediate release, modified release, and pediatric oral formulations for new small-molecule chemical entities.
  • Works with external manufacturers to develop and scale processes, including formulating and implementing strategies for product registration and validation.
  • Supervises activities at contract manufacturers, provides plant-floor support, and manages consultants as needed to ensure effective execution of manufacturing activities and timely delivery of clinical trial materials and commercial drug product.
  • Initiates drug product project activities in response to overall program goals and timelines, requests proposals from prospective manufacturers, contributes to vendor selection, and manages the successful execution of plans consistent with operating budget and program objectives.
  • Troubleshoots manufacturing nonconformances, conducts systematic process risk assessments, and identifies critical process parameters to ensure robust performance during late-stage development and commercial production.
  • Collaborates with Analytical Development, Regulatory Affairs, and Quality Assurance partners to plan and execute on process registration and validation activities that will ensure marketing application acceptance and PAI readiness.
  • Authors development reports, critically reviews batch documentation, and contributes to the preparation of the drug product sections of regulatory submissions.
  • Effectively integrates drug product activities with those of the Analytical Development and Drug Substance functions, as well as Quality Assurance and Regulatory Affairs.
  • Effectively and professionally represents the drug product function on project-level cross-functional teams, collaborating to define phase-appropriate development strategies and meet overall program goals and timelines.

 

What You’ll Need

  • D. in pharmaceutical engineering or related field, and at least 10 years of relevant industry experience in formulation development and drug product manufacturing.
  • Expert knowledge of advanced principles related to product and process development for oral formulations of small-molecule therapeutics, including pediatric formulations modified release dosage forms.
  • Extensive direct experience with drug product development for new small-molecule chemical entities, with demonstrated ability to translate prototype formulations into successful manufacture of drug product on pilot and commercial scales.
  • Experience working across both early and late phases of clinical development, with successful marketing application and commercial manufacturing experience highly desirable.
  • Strong knowledge of GMP requirements for drug product manufacture and associated analytical activities, as well as broader drug development guidelines (ICH, FDA, EMA).
  • Successful track record of managing complex activities at manufacturing sites, including leadership of regular working meetings, clear communication of deliverables and project timelines, and conflict resolution.
  • Strong problem-solving skills and ability to overcome process challenges while working within project timelines.
  • Experience in developing aggressive but realistic timelines for functional activities, and demonstrated success in delivering results according to integrated program plans.
  • Ability to contribute leadership, independent judgement, and an enthusiastic attitude to our fast-paced and dynamic environment.
  • Periodic domestic and international travel to support manufacturing operations will be required (post-pandemic only).

We are committed to building an inclusive culture of belonging that not only embraces the diversity of our people but also reflects the diversity of the communities in which we work and those that we serve. We know that the happiest and highest performing teams include people with diverse perspectives and ways of solving problems, so we strive to attract and retain talent from all backgrounds and create workplaces where everyone feels empowered to bring their full, authentic selves to work.

Repare Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

 

Associate Director / Director, Clinical Scientist

Position: Associate Director/Director, Clinical Scientist

Company: Repare Therapeutics

Location: Cambridge, Massachusetts, USA

Website: http://www.reparerx.com/

 

Repare Therapeutics (Nasdaq: RPTX) is a leading precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor, as well as a CCNE1-SL inhibitor and Polθ inhibitor programs.

Repare is growing at a rapid pace with challenging and exciting opportunities for experienced professionals. We look for scientific and business professionals who are highly motivated, collaborative and, above all, share our passionate interest in fighting cancer and improving patients’ lives.

We are seeking a Clinical Scientist, Associate Director/Director, to play a pivotal role in supporting key oncology programs. This position will report to the Head of Clinical Sciences. The Clinical Scientist will be responsible for providing scientific support for all clinical development activities. If desired the Clinical Scientist may also share or gain experience in our diagnostics development. This role offers a unique opportunity to progress your career by working on novel therapies in the DNA repair field, novel clinical trial designs and innovative approaches to global oncology drug development.

RESPONSIBILITIES

  • Contribute to the development of clinical strategies and trial execution
  • Perform ongoing review and analysis of study safety and efficacy data
  • Provide support as needed for scientific issues that may arise during study execution
  • Collaborate with the Clinical Operations group to develop consistent language and criteria for the Informed Consent Form (ICF), protocol eligibility, protocol safety, Case Report Forms (CRFs), etc.
  • Collaborate with the Regulatory group Drafting of clinical scientific documents such as IND, IND amendments, Investigator Brochures, Annual Reports, CSRs and other FDA submissions, including scientific advice, IND, EoP2, pre-NDA/BLA meetings, NDA/BLA and MAA documents
  • Develop relationships with appropriate consultants
  • Understand the asset’s biological mechanism, clinical strategy, scientific interpretation of disease and target-based literature
  • Understand and support creation of competitor landscape, medical need, regulatory strategy
  • Perform literature searches and summarize the relevant scientific, drug development and medical literature to support document development, such as the investigator brochure, protocol design, clinical study report, competitive assessments, etc.
  • Provide scientific/medical supportive materials to in-house staff and external consultants in the indications being studied
  • Write abstracts and present data at scientific meetings, both internally and externally.
  • Contribute positively to a strong culture of business integrity and ethics
  • Act within compliance and legal requirements as well as within company guidelines

BASIC QUALIFICATIONS

  • Bachelor’s degree in life sciences or related discipline (at minimum)

PREFERRED QUALIFICATIONS

  • Advanced degree (e.g. MS, PhD, PharmD)
  • Minimum of 3 years of experience in a pharmaceutical industry or CRO environment in drug development
  • Prior Oncology Drug Development experience is required.
  • Experience in developing and writing study protocols, study procedures manuals, informed consent forms and clinical study reports.
  • Proven track record of working with investigators, site staff, external experts, Contract Research Organizations and vendors
  • Demonstrated ability to work in matrix teams and in a fast-paced environment.
  • Excellent management, communication and organizational skills required with demonstrated success in leading projects and interacting with cross functional teams
  • Strong Analytical ability.
  • Excellent interpersonal and decision-making skills.
  • Ability to work independently and enthusiasm to deliver the program objectives in a timely manner. Negotiation and influential skills are advantageous.
  • Demonstrated ability to comprehend complex scientific concepts and data. Proficient in reviewing and assessing clinical data.

To protect the interests of all parties, Repare Therapeutics will not accept unsolicited resumes from any source other than directly from a candidate. Any unsolicited resumes sent to Repare Therapeutics, including unsolicited resumes sent to a Repare Therapeutics mailing address, email address, or directly to Repare Therapeutics employees, will be considered Repare Therapeutics property. Repare Therapeutics will not pay a fee for any placement resulting from the receipt of an unsolicited resume. Repare Therapeutics will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees.

Recruiting agencies must obtain advance written approval from Repare Therapeutics’ Finance department to submit resumes, and then only in conjunction with a valid fully-executed contract for service and in response to a specific job opening. Repare Therapeutics will not pay a fee to any Agency that does not have such agreement in place.

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