Daniel Durocher, PhD
Daniel Durocher is a Senior Investigator at the Lunenfeld-Tanenbaum Research Institute where he acts as Director of the Biomedical Program. He is also a Full Professor in the Department of Molecular Genetics at the University of Toronto. Dr. Durocher’s overarching interest lies in understanding how cells maintain genome integrity, with an emphasis on the detection, signaling and repair of DNA double-strand breaks.
Dr. Durocher is widely recognized for his use of functional genomics approaches to study the DNA damage response, and those efforts established ubiquitin as a key organizing molecule in DNA damage repair. Among the awards received by Dr. Durocher in recent years, particularly notable is the 2015 Paul Marks Prize for cancer research awarded by Memorial Sloan Kettering. In 2010, he was also named one of Canada’s Top 40 under 40, a prize that highlights exceptional contributions to Canadian society by individuals under 40 years of age in the arts, science and business spheres.
Dr. Durocher holds a B.Sc. from Université de Montréal, a Ph.D. from McGill University and he did his postdoctoral training at the University of Cambridge, UK.
Frank Sicheri, PhD
Dr. Frank Sicheri is a Senior Investigator at the Lunenfeld Tanenbaum Research Institute at Mount Sinai Hospital and Professor in the Departments of Molecular Genetics and Biochemistry at the University of Toronto. His research focuses on the structural biology of eukaryotic signaling with specific interests in the protein kinase superfamily and the ubiquitin proteolytic system.
His lab made important contributions to understanding normal signaling mechanisms, mechanisms of dysregulation that contribute to disease, and mechanisms of drug action and resistance. He is the recipient of numerous awards and honours including election as a Royal Society of Canada Fellow, the Merck Frosst Prize, Canada Research Chair in Signal Transduction, and Terry Fox Young Investigator Scholar.
Dr. Frank Sicheri holds a B.Sc. and Ph.D. in Biochemistry from McMaster University. He received his post-doctoral training at Rockefeller University under the mentorship of Dr. John Kuriyan.
Agnel Sfeir, PhD
Dr. Agnel Sfeir is the Paine Webber Chair in Cancer Genetics at Sloan Kettering Institute and a full member of Memorial Sloan Kettering Cancer Center (MSKCC). She is also a Professor at Weill Cornell Medicine Graduate School of Medical Sciences. Her research focuses on how mammalian cells maintain genome stability.
Her lab made important contributions to our understanding of DNA double-strand break repair, telomere maintenance, and mitochondrial DNA replication and repair. She is the recipient of numerous accolades, including the NIH director’s new innovator award, Pew-Stewart scholarship for cancer research, Damon Runyon-Rachleff innovator award, Mathers foundation, V-Foundation scholar grant, Pershing Square-Sohn cancer research alliance prize, and an innovator award from The David and Lucile Packard Foundation.
Dr. Agnel Sfeir holds a B.S and M.Sc. in Biology from the American University of Beirut and a PhD in Cell Biology from the University of Texas Southwestern Medical Center. She received her post-doctoral training at the Rockefeller University in the lab of Prof Titia de Lange. Prior to joining MSKCC in 2021, Dr. Sfeir was the Skirball Associate Professor of Genetics in the Skirball Institute of Biomolecular Medicine at NYU school of medicine.