Références Scientifiques Consultez la littérature scientifique qui soutient nos cibles moléculaires et notre approche létale synthétique. octobre 2023 Retrospective baseline biomarker analyses in a first-in-human Phase 1 trial of the PKMYT1 inhibitor lunresertib (RP-6306) in pts with advanced solid tumors harboring CCNE1 amplification and/or deleterious alterations in FBXW7 or PPP2R1 Elia Aguado-Fraile, Sunantha Sethuraman, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS octobre 2023 Preclinical development of PKMYT1 and ATR inhibitor combinations David Gallo, Marc L. Hyer, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS octobre 2023 Preclinical development of PKMYT1 and WEE1 inhibitor combinations David Gallo, Fenil Shah, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS octobre 2023 Circulating tumor DNA (ctDNA) genomic and epigenomic profiling (GuardantINFINITY) for diagnosis of DNA damage repair (DDR) loss of function (LOF) and response monitoring in the TRESR and ATTACC trials Ezra Rosen, Joseph D. Schonhoft, Et Al. AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS juin 2023 Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results Timothy A. Yap, Elisa Fontana, Et Al. Nature Medicine mai 2023 Detection of Biallelic Loss of DNA Repair Genes in Formalin-Fixed, Paraffin-Embedded Tumor Samples Using a Novel Tumor-Only Sequencing Panel Dominik Glodzik, Pier Selenica, Et Al. The Journal of Molecular Diagnostics avril 2023 Characterization of CCNE1 amplifications and associated genomic features in ovarian and uterine cancers Sunantha Sethuraman, Dominik Glodzik, Et Al. AACR 2023 avril 2023 Investigating Wee1 and Myt1 combined inhibition as a potential cancer therapeutic strategy Sargun Sokhi, Joanne Hadfield, Et Al. AACR 2023 avril 2023 Tumor heterogeneity of CCNE1 copy number assessed by fluorescence in situ hybridization (FISH) in ovarian and uterine cancers Adam Petrone, Elia Aguado-Fraile, Et Al. AACR 2023 septembre 2022 Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ Monica Bubenik, Pavel Mader, Et Al. Journal of Medicinal Chemistry 12345 Notre pipeline comprend plusieurs programmes de développement. Voir Notre Pipeline
